C-type natriuretic peptide (CNP) shows remarkable sequence homology to atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) within the 17-residue ring portion formed by a pair of cysteine residues and being the third member of the natriuretic peptide family. Sequence analysis reveals that there are at least two exons in the coding region for preproCNP. Mature forms of CNP in body are CNP22 and its N-termi-nally elongated form CNP53. As an agonist, CNP selectively bind to natriuretic peptide receptor B (NPR-B) which has a single member-spanning helical domain and exert its biological effects by activating its C-teminal guanylate cyclase to catalyse formation of cyclic guanosine monophosphate (cGMP). CNP can also bind to natriuretic peptidereceptor C (NPR-C) which has high binding affinities for all of the natriuretic peptides. The synthesis and release of CNP are regulated by many cy-tokines, and CNP is metabolized by two main pathways : internalization and degradation through the binding with NPR-C or hydrolysis by neutral endopeptidase. CNP and its receptor distribute widespreadly in various tissues including vessels, blood and central neural systems, and produce effects of vasodilation, antianxiely effect and regulations of cell proliferation and endocrine.

The present study was to investigate the analgesic effect and mechanism of meto-clopramide (MCP) on a rabbit visceral pain model. The results showed that MCP (8 mg? kg-1,iv) could produce a significant analgesic effect on visceral pain (P

Objective: To explore the relationship between parental control and aggressive behavior of middle school students. Methods: Random cluster sampling was used to select 1 046 students.Information was collected through the Chinese version of Parental Control Questionnaire and Buss ＆ Perry Aggression Questionnaire. Results: The score on anger were high among female students and the total score were high among male students(t=6.28,2.56,P<0.01).Multiple comparison showed. the grade two junior middle school students’aggression level is significantly higher than grade three junior middle school students and grade one, two high school students(t=3.22,4.07,3.01,P<0.05). There were significant gender differences in parental control,father’s behavior control and father’s psychological control(P<0.05).Parental control shows a significant grade difference,multiple comparison showed, parental control among junior middle school students is significantly higher than that among high school students(t=3.22, 4.07, 3.01, P<0.05).Parental control and aggressiveness of the students were significantly positively correlated(r=0.16,0.29).There was a significant positive correlation between the psychological control of the parents and the aggressiveness of the boys(r=0.26,0.23).The behavior control and psychological control of the parents were positively correlated with the aggressiveness of the girls(r=0.09,0.13,0.29,0.35)(P<0.05).The Logistic regression analysis showed,father’s psychological control(OR=0.50,95%CI=0.21-0.79) and mother’s psychological control(OR=0.32,95%CI=0.02-0.62) showed significant positive association with aggression of the boys.Mother’s psychological control(OR=0.55,95%CI=0.23-0.87)and parents’ control(OR=0.17,95%CI=0.01-0.33) were positively associated with aggression of the girls(P<0.05). Conclusion Effective intervention of parental control might help prevent and control aggressive behavior of middle school students.

Objective To investigate the status quo of specific psychological reaction in patients with cervical intraepithelial neoplasia and to analyze its influencing factors.Methods A total of 243 patients with cervical intraepithelial neoplasia selected by simple random sampling were investigated with the general data questionnaire and process outcome specific measure (POSM).Results The score of the Chinese version of the POSM was (34.60±7.464) with high scores in worrying about family planning, sexual life, cancerization and health. There were statistically significant differences in the scores of POSM among patients with different ages, ways of medical payments, marital status, and whether they had kids and diseases (P<0.05). The multiple linear regression showed that ages and disease classification were the main influencing factors of the level of specific psychological reaction of patients.Conclusions Patients with cervical intraepithelial neoplasia are with specific psychological reaction. Nursing staff in clinical nursing should pay attention to mental status in young and low grade patients with cervical intraepithelial neoplasia, provide specific nursing intervention and promote physical and mental health of patients.

Objective:To explore the effect of postpartum evidence-based rehabilitation nursing program in primiparas.Methods:From January 2019 to March 2021, convenience sampling was used to select primiparas who gave birth in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University as the research subject. The primiparas who were hospitalized from January to December 2019 were set as the control group ( n=80) , and the primipara who were hospitalized from January 2020 to March 2021 were set as the research group ( n=94) . The control group received routine rehabilitation nursing, while the research group received postpartum evidence-based rehabilitation nursing. The health status and pelvic floor function of primiparas were compared between the two groups. Results:The total incidences of primiparas in the research group were lower than those in the control group in terms of difficulty in breastfeeding, incompatibility with the role of mother, indifferent family attitude, anxiety and depression, mastitis, urinary retention, urinary incontinence and constipation, and the difference was statistically significant ( P<0.05) . After intervention, the pelvic floor muscle voltage of classⅠ andⅡ muscle fibers in primiparas in the research group was higher than that in the control group, and the difference was statistically significant ( P<0.01) . Conclusions:Postpartum evidence-based rehabilitation nursing program can help improve maternal health and improve pelvic floor function.