Objective To compare the effects of the quadruple, triple therapy for helicobacter pylori in peptic ulcer dis-ease to guide clinical drug use. Methods From October 2012 to May 2013, 120 patients with Hp positive peptic ulcer in our hospital were divided into two groups randomly. Patients treated with the quadruple or triple therapy for two weeks. The cure rates and the eradication rates for Hp were observed during and after treatment. Results The total cu-rative rate and eradication of the quadruple chemotherapy group were better than that of the trigeminy therapy group(P<0.05). Conclusion The application of the quadruple therapy has a good clinical therapeutical effect on gastroduo-denal ulcer, and it is worthy of being used in a wide range.