This study was aimed to explore the death rule of viral hepatitis patient according to the 24-calendar cycle and time.Information of 40 681 inpatients diagnosed as viral hepatitis from 20 triple-A hospitals in China were collected from December 2003 to August 2011.The death rule of viral hepatitis patient according to the 24-calendar cycle and time was analyzed.It is the first time to put traditional Chinese medicine (TCM) concept of time into survival ending.Its mechanism was explained from the aspects of both TCM and modern medicine.It provided a reference method to combine TCM theory and clinical practice.The results showed that among 40 681 patients,36 547 patients had treatment ending.Among them,386 patients were dead,with the total death rate of 1.06％;308 patients were diagnosed as viral hepatitis B,which was about 79.79％ of the whole dead patients.The proportion of the death time is focused on the Great Heat and the Cold Dew,which is about 6.67％ and 6.4％,respectively.And the percentage of death in the winter is lowest,which is about 3％.The highest percentage of death in one day is Shen-Shi (from 3 pm to 5 pm,23.82％) and You-Shi (from 5 pm to 7 pm,21.78％).It was concluded that the death rule of viral hepatitis patient was at the highest percentage in summer and autumn;that of the spring was the second;and that of the winter was the lowest.In one day,the highest percentage of death lies in Jin-Shi (from 3 pm to 7 pm).