1.Effects of Ilexonin A on acute hypoxic pulmonary vasoconstriction in rats
Chinese Journal of Pathophysiology 1986;0(01):-
Acute hypoxic pulmonary vasoconstriction (HPV) plays an important role in physiological regulation. The purpose of this study was to explore the effects of Ilexonin A on hemodynamics and HPV, and their relation to prostaglandins (PG_(?)) and leukotrienes (LT_(?)).The results show that the high pulmonary vascular resistance induced by Ilexonin A in normoxic rats may be partially caused by the increased LTs and have no relation to PGs. Ilexonin A may potentiate HPV at least by two ways: replacing the production of PGs (especially PGI_2) in hypoxic Wistar rats, and increasing LTs production.
2.Diagnosis,treatment and medical evaluation of anatomical abnormalities in nasal cavity in aircrew
Xianrong XU ; Yang ZHANG ; Xiaoli MA
Medical Journal of Chinese People's Liberation Army 1981;0(04):-
Objective To sum up the experiences of diagnosis,treatment and medical evaluation of the anatomical abnormalities in nasal cavity(AANC,including deviation of nasal septum and turbinate hypertrophy) in aircrew.Methods Case data of 91 pilots with CANC were analyzed.The classification and typing of AANC and secondary barotraumas associated with typing of AANC were studied.Results There were 50 cases of class I AANC(with symptoms or signs on ground),41 cases of class II(no symptoms or signs on ground but with symptoms of secondary barotraumas in flight,including IIa 10 cases:with symptoms of secondary barosinusitis,IIb 26 cases:with symptoms of secondary barotrauma of ear,IIc 5 cases:with symptoms of secondary barosinusitis and barotrauma of ear after flying).For the typing of AANC,there were 41 cases of nasal septum deviation,29 cases of inferior turbinate hypertrophy,8 cases of middle turbinate hypertrophy,and 13 cases of nasal septum deviation and turbinate hypertrophy.85 cases were still in a qualified position to continue their flying job,1 pilot was transferred from fighter to transport pilot,2 pilots were temporarily grounded,and 3 were permanently grounded.Conclusions AANC is very common in aircrew.AANC in aircrew is classified and typed according to the effect of gas pressure adjustment functions of ear and nasal sinus.The classification and typing are of important implication in clinical aviation medicine.Medical workers must unify the qualification criteria in selection for air candidates,and also in diagnosis,treatment,medical evaluation of disease in aircrew.This is an important measure to improve the health quality and ensure combat effectiveness for the air force.
3.Effect of obstructive sleep apnea/hypopnea syndrome (OSAHS) on the cognitive function of pilots
Li CUI ; Xianrong XU ; Ling WANG
Medical Journal of Chinese People's Liberation Army 2001;0(11):-
Objective To explore the effects of obstructive sleep apnea/hypopnea syndrome (OSAHS) on the cognitive function of pilots. Methods The cognitive function of 13 pilots diagnosed as severe OSAHS and 10 healthy pilots as control was evaluated using Epworth Sleepiness Scale (ESS), Flicker Fusion Frequency Indicator, Many Reaction Time Tester, Space Place Memory Span Tester, Attention Instrument and Guard Tester. The correlation analyses were also performed between the ESS, AHI, MinSaO2% with the results of each cognitive test in the OSAHS group. Results Compared with the healthy control subjects, the scores of ESS in OSAHS group were significantly higher (P
4.The impact of Angong Niuhuang Wan(安宫牛黄丸) on orexin-A,Leptin and neuropeptide Y in patients with obstructive sleep apnea-hypopnea syndrome
Ying ZHOU ; Xianrong XU ; Yuhua LI ; Lin XU
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2006;0(06):-
Objective To observe the impact of Angong Niuhuang Wan(安宫牛黄丸) on orexin-A,neuropeptide Y(NPY) and Leptin in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods Total 50 mild and moderate cases of OSAHS which were definitely diagnosed by the results of polysomnogram′s monitoring were selected and randomly divided into treatment group and control group(each n=25).The treatment group took one pill of Angong Niuhuang Wan everyday before sleep for 30 days,while the control group received no treatment.Then the levels of orexin-A,NPY and Leptin were tested by radio-immune assay and enzyme linked immunosorbent assay(ELISA) to compare the changes of 3 indexes before and after the treatment and compare the result differences between the two groups.Results Compared with the control group,after treatment,apnea hypopnea index(AHI) and arousal index of treatment group were obviously decreased((16.33?3.57) times/h vs.(22.23?9.98) times/h,(103.58?32.90) times/s vs.(127.89?42.78) times/s),the average pulse oximetric saturation(MSpO2) and the lowest pulse oximetric saturation(LSpO2) were significantly increased(0.950?0.032 vs.0.934?0.048,0.830?0.041 vs.0.826?0.127,P0.05).The correlative analyses indicated that the levels of orexinA,Leptin and NPY in the patients of OSAHS had positive correlations with AHI(r1=0.445,r2=0.480,r3=0.454) and awareness index(r1=0.613,r2=0.510,r3=0.479,P
5.Surgical treatment of burns for 47 pediatrics patients
Jun NI ; Haifeng GU ; Xianrong XU ; Ruicai CHEN ; Xingmei ZHANG
Journal of Regional Anatomy and Operative Surgery 2013;(6):635-636,639
Objective To investigate the characteristic of surgical treatment of burns in pediatrics patients. Methods From January 2006 to March 2012,47 pediatrics patients and 244 adult patients were received the surgical treatment in our hospital. The clinical data of two groups were analyzed retrospectively and compared. Results The female ratio in pediatric patients was higher than adult group,and almost patients received operation,especially plastic surgery and skin repair,with less surgeries of wound repair and infected surgeries. The preopera-tive physiological index between two groups was no significantly different. Conclusion On the premise of effective preoperative preparation, we could carry out surgical treatment of burns for pediatrics patients positively.
6.Content Determination of Sinalbin in Sinapis alba Decoction Piece by HPLC
Min XU ; Fan YE ; Xianrong LAI ; Yan YANG
China Pharmacy 2016;27(18):2549-2550,2551
OBJECTIVE:To establish a method for the content determination of sinalbin in Sinapis alba decoction piece. METHODS:HPLC was performed on the column of Sepax HP-C18 with mobile phase of 50% acetonitrile-water solution(contain-ing 5 mmol/L tetraoctyl ammonium bromide)at a flow rate of 1.0 ml/min,detection wavelength was 227 nm,column temperature was 30 ℃,and the injection volume was 10 μl. RESULTS:The linear range of sinalbin was 0.010 1-0.202 4 mg/ml(r=0.999 7);RSDs of precision,stability and reproducibility tests were lower than 2%,recovery was 98.51%-104.62%(RSD=1.90%,n=9). CONCLUSIONS:The method is simple,accurate and reliable,and can be used for determination of sinalbin in Sinapis alba decoc-tion piece.
7.The Survey of the Main Diseases Demonstrated by Uneven Pulse on the Base of Viral Myocarditic Clinic Literature
Hui XU ; Xianrong WEN ; Ye TIAN ; Huaiping XI
International Journal of Traditional Chinese Medicine 2009;31(5):455-456
Objective To explore the epidemiologic rule of main diseases demonstrated by uneven pulse. Methods With the method of literature analysis, we summarized and analyzed the literatures of the uneven pulse published in recent 20 between the uneven pulse and the palpitation, thoracic stuffiness, hypodynamia, dizziness, and abdominal distension. Conclusion Uneven pulse demonstrates many diseases besides blood stasis syndrome, thus we should determine the disease combined with other clinical symptoms for consideration, but uneven pulse alone.
8.The Application of Vestibular Functional Test in the Diagnosis and Evaluation of Flight Illusion in Pilots
Zhanguo JIN ; Xianrong XU ; Yuhua LIU ; Yang ZHANG
Journal of Audiology and Speech Pathology 2004;0(06):-
0.05). ②Among 30 pilots with abnormal vestibular functions,19 were permanently grounded and 11 were permitted to return their flying station. 36 pilots returned to fly in 45 cases with normal vestibular functions. The permanently grounded rate had significant differences between the two groups with normal and abnormal vestibular functions. (P
9.Effect of transcatheter arterial chemoembolization with Alginate microspheres-Adriamycin on angiogenesis in rabbit hepatic VX2 carcinoma
Kaiyuan XU ; Yinghua ZOU ; Xianrong QI ; Guodong HU
Chinese Journal of Medical Imaging Technology 2010;26(2):217-220
Objective To evaluate the influence of transcatheter arterial chemoembolization (TACE) with Alginate microsphere-Adriamycin on angiogenesis in VX2 liver tumor. Methods Thirty New Zealand rabbits were randomly divided into 5 groups (each n=6), and VX2 carcinoma was implanted in the left lobes of the livers. TACE was performed with Alginate microsphere (Group A), Alginate microsphere-Adriamycin (Group B), Lipiodol (Group C), Lipiodol-Adriamycin (Group D), and control group (Group E), respectively. Three weeks later, the animals were killed and the samples were evaluated with immunohistochemical reaction to examine the VEGF expression and MVD count. Results The positive rate of VEGF expression was 66.67%, 50.00%, 100%, 83.33% and 66.67% respectively in five groups (P>0.05). MVD count was 55.36±7.02, 41.27±8.45, 82.42±6.23, 67.81±11.42 and 62.46±7.54 respectively in five groups. MVD value of group C was higher than that of group A and group B (P<0.05); of group B was lower than that of group D (P<0.05). Spearman rank correlation analysis showed a correlation coefficient of 0.726 between VEGF and MVD (P<0.01). Conclusion TACE with Alginate microsphere-Adriamycin can reduce VEGF expression and MVD of VX2 liver tumor in rabbits, but the possibility of tumor blood vessels rapid occlusion and therefore resulting in tumor necrosis can not be ruled out.
10.Preliminary study on diplopore puncture of tympanum and intratympanic administration for management of acute secretory otitis media
Zulin TAN ; Yang ZHANG ; Xianrong XU ; Jidong ZHANG ; Zhanguo JIN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2010;(1):16-18
Objective:To evaluate the therapeutical effects of diplopore puncture of tympanum and intratympanic administration(DPTIA) on patients with acute secretory otitis media(ASOM).Method:One hundred and forty -one cases with ASOM were divided into two groups randomly,with 69 cases(80 ears) in group A(experimental group) and 72 cases(84 ears) in group B(control group).Group A was treated with DPTIA combined with medication, group B was treated with haplopore puncture of tympanum combined with medication. All patients accepted 1 to 3 courses of treament,and were observed during the period of treatment and 3 months after treatment.Result:The factors (including gender, age, side of ailing ear, course of disease, air-bone gap in the pure tone average,and acoustic immitance type in ailing ear) which may impact the prognosis were matched in two groups prior treatment(P>0.05). While there was a significant difference in the cure rate and the total effective rate respectively between two groups after treatment(P<0.05).No adverse reaction or complication was seen.Conclusion:DPTIA is a safe, reliable and effective way to manage patients with ASOM.