2.Clinical study of allogeneic hematopoietic stem cell transplantation for patients with leukemia failing to achieve remission with chemotherapy.
Ju-xian TANG ; Kang-er ZHU ; Tao ZHANG
Chinese Journal of Hematology 2013;34(3):267-268
Adolescent
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Adult
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Child
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Female
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Follow-Up Studies
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Hematopoietic Stem Cell Transplantation
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Humans
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Leukemia
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therapy
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Male
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Middle Aged
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Prognosis
;
Young Adult
3.Analysis of the results of bilingual teaching with seven-year medical students
Fang WANG ; Lin ZHANG ; Yanjin MOU ; Junjie TAO ; Xian JI
Chinese Journal of Medical Education Research 2011;10(2):183-185
By analyzing data from a questionnaire survey on bilingual teaching, we evalueted the results of bilingual teaching for seven-year medical students and the main problems of bilingual teaching and solutions accordingly. An uneven English level on the part of teachers and students and imperfect materials etc. affect the overall results of bilingual teaching. Therefore persistent efforts need to be made in enhancing the teachers' English level, improving teaching methods and compiling proper textbooks so as to genuinely improve the bilingual teaching program.
4.Study on physicochemical properties of storax ?-cyclodextrin inclusion complex
Hongtao SONG ; Tao GUO ; Minghong ZHAO ; Ruhua ZHANG ; Xian LI ;
Chinese Traditional and Herbal Drugs 1994;0(06):-
Object To study the phsiochemical properties of storax ? cyclodextrin (? CD) inclusion complex Methods The inclusion complex was identified by the methods of TLC, X ray powder diffractometry and IR The solubility and dissolution rate of cinnamic acid in inclusion complex were investigated by HPLC Results The TLC showed that the main composition of storax had no change before and after being included by ? CD The spectra of X ray powder diffractometry and IR of the inclusion complex were remarkably different from those of storax and storax ? CD mixture It was shown a great improvement of the solubility and dissolution rate of cinnamic acid in the inclusion complex in 0 1 mol/L HCl, pH 6 6 and pH 7 5 phosphate buffer solution Conclusion The storax ? CD inclusion complex exhibits some new physical characteristics and its physiochemical properties are greatly changed comparing with those of storax
8.Development of anti-influenza drug.
Tao ZHANG ; Cheng-Yu WANG ; Yu-Wei GAO ; Song-Tao YANG ; Tie-Cheng WANG ; Xian-Zhu XIA
Chinese Journal of Virology 2011;27(5):475-480
Animals
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Antiviral Agents
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pharmacology
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therapeutic use
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DNA-Directed RNA Polymerases
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antagonists & inhibitors
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Drug Discovery
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Hemagglutinin Glycoproteins, Influenza Virus
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chemistry
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metabolism
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Humans
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Influenza A virus
;
drug effects
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genetics
;
metabolism
;
Influenza, Human
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drug therapy
;
Molecular Targeted Therapy
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Neuraminidase
;
antagonists & inhibitors
;
RNA-Binding Proteins
;
antagonists & inhibitors
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Signal Transduction
;
drug effects
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Viral Core Proteins
;
antagonists & inhibitors
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Viral Matrix Proteins
;
antagonists & inhibitors
9.Effect of propofol on brain injury induced by intestinal ischemia-reperfusion in rats
Dongfeng XIAN ; Jun ZHOU ; Tao ZHANG ; Junying GUO ; Cai LI ; Wenqi HUANG
Chinese Journal of Anesthesiology 2016;36(2):157-160
Objective To investigate the effects of propofol on brain injury induced by intestinal ischemia-reperfusion (I/R) in rats.Methods Forty-eight adult male Sprague-Dawley rats,weighing 250-300 g,were randomly allocated to one of 3 groups (n =16 each) using a random number table:sham operation group (group Sham),I/R group,and propofol group (group P).Intestinal I/R was produced by occlusion of the superior mesenteric artery for 90 min followed by reperfusion.In group P,propofol 50 mg/kg was injected intraperitoneally at 30 min before reperfusion,and the equal volume of fat emulsion was given in the other two groups.Blood samples were collected at 24 h of reperfusion for determination of serum tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) concentrations.The cerebral cortex and hippocampus were isolated for measurement of TNF-α and IL-1β mRNA expression (by real-time reverse transcriptase-polymerase chain reaction) and myeloperoxidase (MPO) activity (using colorimetric method).Morris water maze test was carried out at 1,3 and 5 days of reperfusion.Results Compared with group Sham,the serum TNF-α and IL-1β concentrations were significantly increased,the expression of TNF-o and IL-1β mRNA in the cerebral cortex and hippocampus was up-regulated,the MPO activity was increased,and the escape latency was prolonged,and the frequency of crossing the original platform was decreased during reperfusion in group I/R (P<0.05).In group I/R,the concentrations of serum TNF-αand IL-1β were significantly decreased,thc cxpression of TNF-α and IL-1β mRNA in the cerebral cortex and hippocampus was down-regulated,and the escape latency was shortened,and the frequency of crossing the original platform was increased during reperfusion (P<0.05),and no significant change was found in MPO activity in group P (P>0.05).Conclusion Propofol reduces brain injury induced by intestinal I/R through inhibiting systemic and local inflammatory responses in rats.
10.Comparison between content of saponins of Paris polyphylla var. yunnanensis in different areas of Yunnan province.
Hai-Tao LI ; Xian-Wen LUO ; Yan-Hong GUAN ; Li-Xia ZHANG ; Wei-Wei GAO
China Journal of Chinese Materia Medica 2014;39(5):803-806
Six kinds of saponins (I, II, VII, PA, H) content of 22 samples of Paris polyphylla var. yunnanensis collected from different regions of Yunnan province were determined by HPLC, data was analyzed by SPSS 17. The results showed that the effect of altitude on saponin content was not significant, and the effect of growth area of saponins in P. polyphylla var. yunnanensis was significant, saponin content in sample from west Yunnan was significantly higher than that of samples from other regions.
Altitude
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China
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Chromatography, High Pressure Liquid
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Drugs, Chinese Herbal
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analysis
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Liliaceae
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chemistry
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Saponins
;
analysis