Objective To investigate the relationship between coagulation factor ⅩⅢ deficiency and delayed intracranial hematoma after craniotomy. Methods The clinical data of 2 cases with delayed intracranial hematoma induced by coagulation factor ⅩⅢ after craniotomy were analyzed and compared with the data of 58 cases with delayed intracranial hematoma induced by other causes during the same period, so as to find out the clinical characteristics of the disease induced by coagulation factor ⅩⅢ. Results The delayed intracranial hematoma induced by the deficiency in coagulation factor ⅩⅢ was commonly located in the operative regions after surgery, and the process was insidiousand fast. Conclusion When the delayed intracranial hematoma is confirmed after craniotomy, the deficiency in coagulation factor ⅩⅢ should be taken into consideration. The prognosis will be satisfying if the diagnosis and treatment are in time.

Objective To compare the diagnostic value of renal ultrasound scan (RUS) and 99Tcmdimercaptosuccinic acid (DMSA) renal scintigraphy in children with acute pyelonephritis (APN). Methods In all, 165 children with initial clinical diagnosis of APN, aged from 1.5 months to 11 yrs ( median 20 months), were included in the study, all of which were examined with RUS and DMSA renal scientigraphy. The diagnosis with DMSA renal scientigraphy results was taken as the standard reference to evaluate the diagnostic sensitivity and specificity of RUS. Results Of 99 out of all 330 kidneys that were found abnormal on DMSA renal scientigraphy, 31 were abnormal on RUS. Of the rest normal kidneys on DMSA scans renal scientigraphy, 4 were abnormal on RUS. Thus diagnostic sensitivity of RUS for APN was 31.3%(31/99) and specificity was 98.3% (227/231). Conclusions Although RUS provides with high diagnostic specificity for children with APN, its low sensitivity may underestimate the clinical evaluation of APN.More often than not, 99Tcm-DMSA renal scientigraphy is a clinical necesscity for the definite RUS diagnosis.

Objective To investigate the long-term effects of non-surgical treatment on clinical and hematologic states of patients with generalized aggressive periodontitis (GAgP).Methods Patients with GAgP(n =25) and healthy controls (n =28) were recruited.The clinical parameters,including probing depth(PD),bleeding index(BI),attachment loss(AL) were examined and recorded.Blood cell variables,including white blood cells (WBC),leukocyte,neutrophil,and lymphocyte counts,as well as serum triglycerides,fasting glucose and protein parameters,including total protein,albumin,globulin,and albumin/globulin ratio(A/G),were analyzed.Twenty-five GAgP patients received non-surgical treatment and the clinical and blood parameters 3 to 7 years after treatment were re-evaluated.Clinical and hematological parameters of the two groups were compared.Comparisons of clinical and hematologic parameters pre-and post-treatment in GAgP group were performed through one-way ANOVA and paired-t test.Results Elevated white blood cells,neutrophil numbers and serum total protein,globulin levels were observed in patients with GAgP compared to controls [(6.3 ± 2.0) × 109cell/L vs.(5.4 ± 1.0) ×109cell/L,(4.1 ±1.8) × 109 cell/L vs.(3.0 ±0.9) × 109 cell/L,(78.2 ±4.4) g/L vs.(75.6 ±4.6) g/L and (29.3 ±3.8) g/L vs.(26.5 ±3.9) g/L respectively,P ＜0.05].A/G ratio was lower in the GAgP group than in the control group (1.7 ±0.2 vs.1.9 ±0.3,P ＜0.01).Three to seven years after periodontal treatment,the reduction of PD and BI was observed in GAgP group (P ＜ 0.05).There were significant decreases of WBC count,neutrophil count,serum total protein and globulin level,and significant increases of albumin level and A/G at 3 to 7 years after treatment (P ＜ 0.05).Conclusions Non-surgical treatment may have long-term beneficial effect on the periodontal clinical status and hematologic parameters of generalized aggressive periodontitis.

Objective To evaluate the accuracy of quantitative coronary angiography ( QCA ) assessment on target lesion and reference vessel in patients with diabetes mellitus with intravascular ultrasound (IVUS) measurements as golden standard. Methods QCA and IVUS were performed in 52 diabetes mellitus patients [35 males, mean age (62.3 ±7. 1)years]. Regression equation was ascertained with the IVUS derived plaque burden as dependent and QCA derived vessel stenosis as independent variable. The measurement results derived from the two modalities on proximal and distal reference vessels were compared. Result The regression equation (constant = 0. 8286, P = 0. 001) of plaque burden and vessel stenosis derived from two modalities were significantly correlated ( r = 0. 691, P < 0. 001 ) but QCA overestimated the stenosis severity (57. 9% ± 15. 5% vs. 53. 5% ± 12. 9% , P <0. 01 ). Target vessels negative remodeling index in these patient was 0. 87 ±0.23. QCA significantly underestimated the proximal and distal reference segments vessel diameters [ ( 0. 81 ± 0. 24 ) mm, ( 0. 64 ± 0. 17 ) mm, all P < 0. 05 ] as compared to IVUS results. Conclusion Due to the significant negative vessel remodeling, QCA overestimated the stenosis severity and underestimated the reference segments vessel diameters in patients with diabetes mellitus.

Objective To compare the value of intravascular ultrasound (IVUS) and assess the value of quantitative coronary angiography ( QCA) and 64 multi-detector computed tomography ( MDCT) on unstable anginas (UAP) risk stratification. Method A total of 61 UAP patients (low risk; 17, middle risk; 33 and high risk; 11) were recruited, 71 vessels were examined by MDCT, QCA and IVUS. Plaque characteristics (soft, fibrous, calcified and mixed plaques) and plaque burden at minimum area ( ≤50% , 51%-74% and ≥75%) were detected, calculated and analyzed. Results derived from various detection methods were compared. Results Plaque burden detection by QCA was comparable to IVUS results for low and middle risk UAP ( r = 0. 768 and r = 0. 721, respectively; all P < 0. 01 ) but not for high risk UAP ( 67% ± 14% vs. 75% ± 16% , P < 0. 01) due to significant positive vessel remodeling ( remodeling index = 1.21±0.31). The high negative predict value of MDCT for stenosed coronary vessels(87. 8%-96. 3%) was valuable for exclusion of coronary heart disease but MDCT was not able to identify fibrous cap( kappa = 0. 235) and lipid core ( kappa = 0. 245 ) . Extent of remodeling index, external elastic membrane area, minimum lumen area, plaque burden, plaque rupture and thrombosis increased in proportion to increasing risks of UAP patients. Conclusions QCA is a suitable tool for assessing UAP patients with low and middle vessel stenosis but underestimated the stenosis degree in UAP patients with high vessel stenosis. MDCT is valuable for exclusion vessel disease but not useful for identifying soft and fibrous plaque. Soft plaque with positive remodeling index and minimum lumen area <4 mm~2 derived from IVUS could correctly identify UAP patients with high degree of vessel stenosis.

Objective Novel stents loaded with antibody against CD105 were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting activated endothelial cell. Methods Thirty Stents coated with antibody against CD105, thirty unloaded polymer, and thirty bare metal stents were deployed in 90 coronary arteries of 30 minipigs. Oral aspirin (300 mg before operation and 100 mg post operation) and clopidogrel (300 mg before operation and 75 mg post operation) were orally administrated. Coronary artery quantitative analysis was completed by coronary arteriography,the vascular endothelium changes were observed under scanning electron microscope and the vascular morphological changes were observed under light microscope 7 and 14 days after operation. Results Complete procedural and angiographic success was achieved in all 30 minipigs. There were no major adverse cardiac and cerebrovascular events. At 7 days, there was no difference for mean neointimal area and percent rea stenosis among various groups. At 14 days, endothelialization scores were significantly higher in the CD10S antibody-loaded stents and bare metal stents group than in sirolimus-eluting stents group (1.78 ± 0.49, 1. 50±0. 67 vs. 1. 08±0. 29, all P < 0. 05 ), mean percent area stenosis in the CD105 antibody-loaded stents, sirolimus-eluting stents group were less than that in bare metal stents group [ (23. 8± 4) % , (24. 2±2)% vs. (38.0 ±3)% , all P <0.05] ,mean angiographic late luminal loss in the CD105 antibody-loaded stents, sirolimus-eluting stents group were less than that in bare metal stents group [ (0. 29±0. 28) mm, (0. 28±0. 02) mm vs. (0.41±0. 01) mm, all P < 0. 05 ]. There was no difference for mean percent area stenosis in the CD105 antibody-loaded stents and sirolimus-eluting stents group. The mean neointimal area in the CD105 antibody-loaded stents,and sirolimus-elutingstents group were less than that in bare metal stents group [(0.88±0.08) mm2, (0. 89 ±0. 12mm)2 vs. ( 1. 00 ±0. 14) mm2 , all P<0.05] and there was no difference for the mean neointimal area in the CD105 antibody-loaded stents and sirolimus-eluting stents group. At 7 and 14 days, there was no difference for the injury score and the inflammation score among various groups, scanning electron microscopy evidenced enhanced endothelial coverage on CD105 antibody-loaded stents compared to sirolimus-eluting stents group. Conclusion Stent coated with antibody against CD105 could effectively reduce in-stent restenosis and accelerate endothelialization in th eminipigs.