Chronic osteomyelitis is a severe infectious disease caused primarily by Staphylococcus aureus and characterized by recurrent episodes of sinus drainage, chronic swelling, and bone destruction. Its treatment is challenging due to high rates of recurrence and disability which impose significant physical and financial burdens on its patients. Therefore, it has become a major global health problem that requires urgent attention. Recent research into its pathogenesis has been intensified due to advancements in medical technology and microbiology. In addition to antibiotic resistance, current studies have identified biofilm formation, intracellular infection, invasion of the bone trap network structure, and presence of small colony variants as factors contributing to this disease, providing new perspectives to understand the complexity of its treatment. This article reviews the impact of these mechanisms on the treatment challenges and explores the latest therapeutic prospects of the disease.

Molybdenum target mammography is a common screening method for breast diseases.However,there are problems with the traditional protective clothing,such as cumbersome combination of accessories,insufficient protection of multiple exposed parts,and inappropriate size.To this end,a new type of protective clothing for mammography examination was developed and designed,which was improved and optimized for the above problems,and effectively protected X-ray-sensitive tissues and organs such as breast,thyroid,thymus,and gonads on the unphotographed side through the pasting switch of Velcro.This improvement can improve the comfort and wearing experience of mammography examiners wearing protective clothing,improve the efficiency of examinations,and provide new protective measure for clinical practice.