A series of reform on the teaching of medical chemistry has been carried out to improve the quality of instruction,which includes the goal of instruction,the content of course and the teaching method.Good results have been achieved.

The hydride generation technique was used to determination of germanium in the presence of L-cysteine.The GeH4 was absorbed and coloured by a mixed solution of 2-(5-NO2-2-pyridylazo)-5-diethylaminophenyl(5-NO2-PADAP),NaClO and (CH2)6NH+.The maximum absorption of the colour complex was at 564nm.Its apparent molar absorption coefficient was 1.84×105L·mol-1·cm-1.Beer＇s law was obeyed for 0～500μg/L germanium.The recoveries of spiked samples were in the range of 89%～97%,while the relative standard deviation was less than 6.3%.This method is sensitive,simple and reproducible.The method has been applied to the determination of Ge in the chinese medicine with satisfactory result.

BackgroundAlcohol dependence and related health problems have attracted greater than ever attention in recent years. Alcohol dependence not only affected personal behavior control ability， but also brought adverse effect to families and society. ObjectiveTo analyze the relationship between cognitive function and personality traits among male alcohol-dependent patients with aggressive behavior， in order to provide references for improving the cognitive function of male alcohol-dependent patients with aggressive behavior. MethodsMale patients with alcohol dependence attending Hunan Brain Hospital from March 2020 to March 2022 and fulfilling the International Classification of Diseases， tenth edition （ICD-10） diagnostic criteria were enrolled. According to the score of Modified Overt Aggression Scale （MOAS）， participants were classified into aggressive behavior group and non-aggressive behavior group at 1∶1 ratio， each with 80 cases. The enrolled subjects were then evaluated using Revised Eysenck Personality Questionnaire Short Scale for Chinese （EPQ-RSC） and Repeatable Battery for the Assessment of Neuropsychological Status （RBANS）. Pearson correlation analysis was utilized to examine the correlation between EPQ-RSC and RBANS scores among alcohol-dependent patients with aggressive behavior. ResultsScores on each subscale in RBANS were all lower in aggressive behavior group than those in non-aggressive behavior group （t=2.176， 2.580， 2.076， 2.308， 2.193， P<0.05）， and scores on each dimension in EPQ-RSC in aggressive behavior group were higher than those in non-aggressive behavior group （t=4.497， 5.242， 6.459， P<0.01）. Pearson correlation analysis denoted that the scores of introversion/extroversion， neuroticism and psychoticism in EPQ-RSC were positively correlated with the scores of immediate memory， visuospatial/constructional ability， language， attention and delayed memory in RBANS among alcohol-dependent patients with aggressive behavior （r=0.294~0.482， 0.362~0.511， 0.265~0.475， P<0.05）. ConclusionThe cognitive function may have a certain correlation with personality traits in alcohol-dependent patients with aggressive behavior. ［Funded by Scientific Research Project of Hunan Health and Wellness Committee （number， 202103092373）］