OBJECTIVETo map the disease-causing gene in a Chinese family with autosomal dominant retinitis pigmentosa.

METHODSTwenty-seven micro-satellite markers were randomly selected from the region around the known loci of causative genes, and haplotypes were determined by ABI3100 genetic analyzer. Two-point linkage analysis was performed using MLINK.

RESULTSThe Lod score of each marker vs adRP was below 1.

CONCLUSIONThe phenotype of this family may not be caused by mutation of the known disease-causing genes.

Asian Continental Ancestry Group ; genetics ; China ; Female ; Genes, Dominant ; Genetic Linkage ; Genetic Testing ; Humans ; Male ; Microsatellite Repeats ; genetics ; Mutation ; Pedigree ; Phenotype ; Retinitis Pigmentosa ; diagnosis ; genetics ; pathology