OBJECTIVETo evaluate the effect of Helicobacter pylor (Hp) eradication in children with acute idiopathic thrombocytopenic purpura (ITP).

METHODSNinety-three children with acute ITP and Hp infection were divided into two groups and treated with prednisone and Hp eradication (group A, 51 cases) or with prednisone without Hp eradication (group B, 42 cases).

RESULTSThe Hp eradication rate was 94.1% in group A. No difference was found in the therapeutic effects on IPT between the two groups, but the recurrence rate in one year in group A was significantly lower than that in group B.

CONCLUSIONNHp eradication does not obviously enhance the therapeutic effect on childhood acute ITP, but can decrease the relapse rate in one year. HP eradication therapy is recommended in children with acute ITP and Hp infection.

Adolescent ; Anti-Bacterial Agents ; therapeutic use ; Child ; Child, Preschool ; Drug Therapy, Combination ; Female ; Helicobacter Infections ; drug therapy ; Helicobacter pylori ; drug effects ; immunology ; Humans ; Male ; Prednisone ; therapeutic use ; Purpura, Thrombocytopenic, Idiopathic ; immunology ; microbiology

Objective To evaluate the clinical effect of Jianpi tiaozhong powder in the treatment of children with functional dyspepsia ( FD) and its effects on the gastric motility.Methods Ninety children with FD were randomly divided into treatment group and control group , 45 cases in each group.Children in treatment group were given Jianpi tiaozhong powder one hour after the breakfast and supper , 10 mL for five to nine years old children and 20 mL for ten to fourteen years old children.Meanwhile , children in control group were given domperidone syrup orally, the doses of 5-7, 8-10 and 11-14 years old children were 5, 7 and 10 mL, separately.After one -month treatment, the clinical symptoms, side effect, electrogastrogram(EGG), motilin(MOT), soma-tostatin(SS) and gastrin(GAS) were recorded and compared before and after treatment.Results After treatment , the total efficiency of treatment group was 86.67%, significantly higher than that in control group, which was 75.56%( P<0.05 ).Improvement of symptoms in treatment group was more significant than that in control group( P<0.05 ).The percents of normal rhythm before meal were significantly higher than before treatment ( P<0.05 ).The motilin and somatostatin in treatment group were ( 235.7 ±19.4 ) , ( 18.8 ±2.5 ) pg · mL-1 , significantly lower than those in control group , which were ( 267.3 ±17.2 ) , ( 20.3 ±1.4 ) pg · mL-1.Gastrin in treatment group and control group were (168.6 ±17.2), (142.8 ±11.4) pg· mL-1, respectively (P<0.05).The motilin, somatostatin and gastrin after treatment were comparable than those before treatment in two groups ( P <0.05 ).There was no adverse drug reaction in two groups.Conclusion Jianpi tiaozhong powder had precise efficacy and slight side effect on children with FD.