Humans ; Liver Failure, Acute ; etiology ; therapy

Adult ; Humans ; Liver Transplantation ; United States

Hepatorenal Syndrome ; diagnosis ; prevention & control ; therapy ; Humans ; Liver Transplantation

Objective:To investigate the clinical efficacy of honeysuckle extraction liquid combined with nasal irrigation in the treatment of nasosinusitis after radiotherapy of nasopharyngeal carcinoma.Methods:Eighty-two patients with nasosinusitis post-radiotherapy who received treatment between February 2018 and February 2020 in the First Hospital of Jiaxing were included in this study. They were randomly assigned to receive either nasal irrigation with 0.9% sodium chloride injection (control group, n = 41) or atomization treatment with honeysuckle extract liquid plus nasal irrigation with 0.9% sodium chloride injection (observation group, n = 41), once daily for 4 successive weeks. Visual Analogue Scale (VAS) and nasal endoscopic Lund-Kennedy (LK) score, ciliary transport rate, clinical efficacy and adverse reactions were compared between the control and observation groups. Results:After treatment, the nasal congestion score [(0.82 ± 0.10) points], viscous or purulent nasal discharge score [(1.88 ± 0.25) points], olfactory dysfunction score [(1.12 ± 0.15) points], head and face pain score [(0.40 ± 0.06) points] and nasal endoscopic Lund-Kennedy score [(2.03 ± 0.26) points] in the observation group were significantly lower than those in the control group [(1.94 ± 0.26) points, (2.93 ± 0.37) points, (1.73 ± 0.25) points, (0.62 ± 0.09) points, (4.07 ± 0.47) points, respectively, t = 9.156, 15.056, 13.397, 13.023, 9.156, all P < 0.01]. The ciliary transport rate in the observation group [(4.71 ± 0.56) mm/min] was significantly higher than that in the control group [(3.94 ± 0.51) mm/min, t = 15.056, P < 0.01]. Total effective rate in the observation group was 97.56% (40/41), which was significantly higher than 80.49% (33/41) in the control group ( χ2 = 4.493, P < 0.05). In the control group, one patient had epistaxis, and no adverse reaction was observed in the observation group. Conclusion:Honeysuckle extraction liquid combined with nasal irrigation with 0.9% sodium chloride injection is effective in the treatment of nasosinusitis after radiotherapy for nasopharyngeal carcinoma, can greatly improve the symptoms and signs of patients, and is highly safe.

Objective: Large-conductance calcium-activated potassium (BKCa) channel modulates vascular smooth muscle tone. In the present study, we tested the hypothesis that salt, one of the factors which significantly influence blood pressure (BP), can regulate BKCa activity and then elevate blood pressure. Methods: Male Sprague-Dawley rats aged 6 weeks were randomized into high salt diet group (HS) and control group, fed with high salt diet (containing 5% NaCl) and standard rat chow (containing 0.4% NaCl) respectively for 16 weeks. Tail systolic blood pressure (SBP), body weight (BW) and 24-hour urinary output were tested every 4 weeks. Content of urinary Na+ was detected using flame spectrophotometrical method. At the end of 16 weeks, all the rats were killed, the mesenteric arteries were obtained, and single mesenteric smooth muscle cells were isolated at once. The resting membrane potential (Em), the total potassium currents and the currents after perfusion with TEA solution of the cells were all recorded by whole cell patch clamp. The transcriptions of BKCa channel α and β1 subunits in mesenteric arterial vascular smooth muscle cells (VSMC) of each group were calculated by real-time RT-PCR. Results: There was no difference in SBP and BW at each stage between control group and HS group; the urinary Na+ level in HS animals was elevated significantly after 4 weeks. The negative values of Em in HS group VSMCs were reduced compared with those in the control group. Transcriptions of β1 subunit of BKCa channels were decreased in HS group, but α subunit transcriptions did not differ between the two groups. Whole cell potassium currents did not differ between HS and control groups, but BK Ca currents of HS group VSMCs were lower than those of control group ones. Conclusion: Even without elevating SBP, salt-loading can still modulate the expression and activity of BKCa channel in the mesenteric arterial VSMC and elevate vascular tone.

Objective: Large-conductance calcium-activated potassium (BKCa) channel modulates vascular smooth muscle tone. In the present study, we tested the hypothesis that salt, one of the factors which significantly influence blood pressure (BP), can regulate BKCa activity and then elevate blood pressure. Methods: Male Sprague-Dawley rats aged 6 weeks were randomized into high salt diet group (HS) and control group, fed with high salt diet (containing 5% NaCl) and standard rat chow (containing 0.4% NaCl) respectively for 16 weeks. Tail systolic blood pressure (SBP), body weight (BW) and 24-hour urinary output were tested every 4 weeks. Content of urinary Na+ was detected using flame spectrophotometrical method. At the end of 16 weeks, all the rats were killed, the mesenteric arteries were obtained, and single mesenteric smooth muscle cells were isolated at once. The resting membrane potential (Em), the total potassium currents and the currents after perfusion with TEA solution of the cells were all recorded by whole cell patch clamp. The transcriptions of BKCa channel α and β1 subunits in mesenteric arterial vascular smooth muscle cells (VSMC) of each group were calculated by real-time RT-PCR. Results: There was no difference in SBP and BW at each stage between control group and HS group; the urinary Na+ level in HS animals was elevated significantly after 4 weeks. The negative values of Em in HS group VSMCs were reduced compared with those in the control group. Transcriptions of β1 subunit of BKCa channels were decreased in HS group, but α subunit transcriptions did not differ between the two groups. Whole cell potassium currents did not differ between HS and control groups, but BK Ca currents of HS group VSMCs were lower than those of control group ones. Conclusion: Even without elevating SBP, salt-loading can still modulate the expression and activity of BKCa channel in the mesenteric arterial VSMC and elevate vascular tone.

Purpose To discuss the main index of the colour ultrasonographic diagnosis of children's left Renal Vein Entrapment Sydrome(LRVES).Methods By colour ultrasonography,urine microscope examination and urine Ca/Cr ratio determination,eighty-two LRVES children were diagnosed and compared with forty healthy children.Observed at supine position whether narrow caused by pressure or the expanding phenomenon of LRV after being pressed,to examine the ratio of the abdominal aorta(AO) left internal diameter(a) to the front internal diameter(b) of LRV,by using CDFI,blood flow rate in the left lateral position of LRV was judged.Simultaneously,the angle(?) between superio mesentery artery(SMA) and AO was detected.Then standing upright for twenty minutes,and determined a/b ratio.Results In the LRVES group,the LRV blood vessels become narrower,a/b was over 3 at supine position,after standing upright for twenty minutes,a/b was over 4;and LRV blood flow rate becomes slower,? angle becomes smaller,compared with the healthy group,there was statistical significance.Conclusions The main indexes of the LRVES of ultrasonographic diagnosis is to observe the a/b ratio of LRV before and after being pressed (lying on the back and standing upright for twenty minutes) and to detecte the blood flow rate of LRV before pressure and judege the angle between SMA and AO.

The bone turnover markers are composed of the metabolic products of bone matrix and bone cells.The changes of these markers in serum and/or urine represent the status of bone metabolism.To measure the level of these markers will offer important information for evaluating the diagnosis and the responses of therapy in metabolic bone diseases,and to predicat the risk of bone fracture.The biochemistry,measurement and clinical aplication will be introduced in this paper.

Objective: To analyze the Effect of rt-PA thrombolytic therapy on elderly patients with cerebral infarction. Methods: Chosen elderly patients with cerebral infarction between November 2012 to November 2013 as study object, randomly divided into observe group receive rt-PA thrombolytic therapy and control group receive aspirin and Batroxobin, detecting neurological impairment, physical function score and adverse treatment outcomes. Results: 1)before thrombolytic treatment, neurological deficit situation of two groups were no significant difference (P>0.05), after treatment, observation group patients’ neurological deficit scores were significantly lower than control group at each time point (P<0.05); 2)after treatment, limb function defective number of observation group patient was significantly less than observation group(P<0.05); 3)after treatment, observation groups’ adverse outcomes as again infarction, large area cerebral hemorrhage after thrombolysis, plant survival, incidence of death was significantly lower than control group (P<0.05). Conclusion: The injection of rt-PA thrombolytic therapy can significantly optimize neurological and physical function in patients , reducing the incidence of adverse treatment outcomes, with positive clinical significance.

0 05).Plasma ET in the active LN was significantly higher than that in the inactive LN and normal control group ( P