Objective] The treatment of pediatric asthma in remission period is summarized from the positive and negative aspects, in order to provide new ideas and methods for clinical treatment. [Methods] By consulting the related literatures on the traditional Chinese medicine treatment of children with asthma in remission phase, the paper mainly summarized the different physicians' understanding of pathogenesis and approaches to the treatment of pediatric asthma in remission stage. [Results]The treatment of physicians for pediatric asthma in remission phase can be divided into asthenia healthy qi and sthenia pathogenic factor syndrome.The treatment of healthy qi deficiency mainly includes treating lung,spleen,kidney seperately;curing lung-spleen,lung- kidney, spleen-kidney ;treating three viscera meanwhile.The therapy of pathogenic excess contains treating wind,phlegm,stasis respectively;curing phlegm-stasis. [Conclusion]The treatment of traditional Chinese medicine for pediatric asthma has a unique advantage in improving children's physique, reducing the frequency of asthma attacks, and improve children's life quality which has significant clinical effect.

Objective To present the computed tomography (CT)findings and associated pathological features of eight cases of primary he-patic angiosarcoma (PHA).Methods All cases were confirmed by pathology.After a CT scan of the upper abdomen,all cases of PHA un-derwent enhanced scans in the arterial phase,portal venous phase,and delayed phase to observe the CT manifestations.The surgical speci-mens were subjected to conventional hematoxylin-eosin staining and immunohistochemistry and observed under a microscope.Results Of all patients,5 cases were massive type,2 cases were mixed type,and 1 case was multiple nodule type.CT scans revealed inhomogeneous low-density lesions,with necrosis of even lower density in the central part.In 4 cases of massive type,scattered high-density small pieces were observed in low-density areas;in one case of mixed type,high-density nodules were observed on the edge of mass.There were 7 ca-ses of peripheral nodular irregular enhancement in the arterial phase,including 1 case with flocculent central enhancement and another with no enhancement.Lesions remained enhanced in the portal venous and delayed phases,but 1 case had no enhancement.Five in 9 lesions had sharp edges in the arterial and portal venous phases,with“sharpen rim perpendicular to pleura”signs at the boundaries with the surrounding normal liver tissue.The outer edges of 7 lesions were found to have “pseudocapsules”in the portal venous phase.Conclusion CT scans showed a large hypodense lesion with irregular necrotic areas or scattered hemorrhage in PHA patients,whist enhanced scans showed a pro-gressive filling and necrotic area in the central part.There could be“sharpen rim perpendicular to pleura”and“pseudocapsule”signs at the edge.It might be helpful to improve the diagnosis through the above characteristic features.

AIM To observe the effect of APS on bone marrow and spleen progenitor cells in MMC induced myelosuppression in mice. MEHTODS MMC 7 mg?kg -1 was injected ip on day 0, APS 100 mg?kg -1 ?d -1 was given sc in 3 regimens ① on day 0～4, ② on day 0～11,③ 12 doses in 3 weeks. RESULT APS increased the number of bone marrow progenitor cells(CFU C) of MMC treated mice 3 fold, from 1 870 ?40 per femur to 6 240 ?110 per femur on day 3.APS treatment resulted in a higher level of bone marrow CFU C at all time points from day 3 to day 18, in comparison with the control group. APS also significantly stimulated the proliferation of spleen progenitor cells on day 14 (3 fold of control) and day 18(2 fold of control) after MMC treatment, however APS had no effect on spleen progenitor cells before day 14. CONCLUSION These results demonstrate that APS enhances the proliferation and maturation of the progenitors of peripheral blood cells in MMC treated mice.

[Objective] To investigate the clinical efficacy of nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy.[Methods] Seventy patients with adenoid hypertrophy were divided by random digits table method into treatment group and control group with 35 cases each.The patients in control group underwent traditional by-mouth adenoidectomy,while the patients in treatment group were treated with nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation.The operative time and intraoperative blood loss in two groups were calculated.The children were followed up for 6-12 months and the clinical efficacy of snoring,nasal obstruction and hearing and the postoperative complications were observed.[Results]The intrsoperative blood loss in treatment group was significantly lower than that in control group[(2.23±0.74)ml vs.(24.58±8.19)ml](t=19.733,P ＜ 0.01).The total efficiency of snoring,nasal obstruction and hearing in treatment group was 91.4％(32/35),82.9％(29/35)and 77.1％(27/35),respectively,and which was significantly higher than that in control group[68.6％(24/35),62.9％(22/35)and 57.1％(20/35)](x2 =5.354,5.293,5.421,P＜0.01).There,was no residual adenoid and adenoidal hypertrophy recurrence in treatment group,while the postoperative residual adenoid rate in control group was 91.4％(32/35),the adenoidal hypertrophy recurrence rate was 20.0％(7/35).There was significant difference in postoperative complication incidence between two groups(x2 =9.391,P ＜ 0.01).[Conclusions] Nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy has better clinical efficacy,less intraoperative blood loss,no postoperative residual and other complications.It is an ideal method for treating the children with adenoid hypertrophy and worthy of clinical application.

The aim of this study is to clarify whether edaravone postconditioning had protective effect against renal ischemia/reperfusion injury and to compare the protective effect between ischemic postconditioning and edaravone postconditioning. Rats were subjected to 45 min ischemia followed by 24 h reperfusion. The rats were randomly assigned to seven groups: a sham-operated control group, an ischemia/reperfusion group, an ischemic postconditioning group, a normal saline vehicle postconditioning group and an edaravone postconditioning (1, 3, and 6 mg x kg(-1)) group. Renal function was assessed by serum creatinine and BUN concentration, while histological damage of renal tissue was assessed with HE staining. MDA content and SOD activity of renal tissue were determined. TUNEL staining was performed to analyze the apoptosis of the tubular epithelial cells, the protein level of Bcl-2 and Bax in renal tissue was examined by Western blotting. Compared to the ischemia/reperfusion group, edaravone postconditioning significantly decreased serum creatinine and BUN concentration, and ameliorated histological damage of renal tissue. MDA was less after 24 h reperfusion in the edaravone postconditioning group than that in the ischemia/reperfusion group, consistent with an increase in SOD activity. In addition, edaravone postconditioning decreased TUNEL-positive cells and Bax expression, and increased Bcl-2 expression. Results detected in the edaravone postconditioning group showed no significant difference from the ischemic postconditioning group. Edaravone administered during the last 3 min of ischemia, prior to reperfusion induces a pharmacological postconditioning in vivo against renal ischemia/reperfusion injury in rats. This protection is similar to that observed with ischemic postconditioning.

OBJECTIVE: To study the activity of flavonoids WF extracted from Mallotus apelta against duck hepatitis B virus (DHBV).METHODS: One-day-old ducklings were infected with DHBV.7 days later the DHBV-infectious model was established successfully.The model ducklings were administrated with WF of 75 and 150 mg?kg-1 or lamivudine of 50 mg?kg-1 b.i.d.via i.g.gtt for 10 days consecutively.Serums were collected at 5th and 10th day after drug administration and 3th days after drug withdrawal.The level of DHBV-DNA in serum was detected by dot-blotting hybridization test.RESULTS: 75 and 150 mg?kg-1 WF reduced the level of DHBV-DNA significantly(P

Objective To analyze the quality of life (QOL) of mothers of children with cerebral palsy and it's influencing factors.Methods The QOL of 123 children with cerebral palsy and their mothers was assessed a 36-item short form health survey (SF-36) and basic questionnaires combined with interviews.The factors influencing QOL were analyzed with t-tests and one way analysis of variance,and multiple regression analysis was used to determine the main influencing factors.Results Scores on all of the SF-36 items were much lower for mothers of children with cerebral palsy than for mothers of normal children.Average scores in the domains of emotional health,general health and vitality were the lowest (55.28,60.49 and 65.26 respectively).Correlation analysis showed that general health,physical function and role emotions were positively correlated with the child's age.All domains except pain were negatively correlated with the child's condition.Social functioning was positively correlated with the mother's age.The general health,role emotional,social function,and mental health scores were all negatively correlated with the mother's education level.Univariate analysis showed that the child's age and condition,the mother's education level and occupation,and the father's occupation all significantly predicted the mother's QOL.Multivariate regression analysis confirmed that the child's age and the father's occupation had significant predictive power.Conclusions The QOL of the mother of a child with cerebral palsy is mainly influenced by the child's age and condition,the mother's education level and occupation,and the father's occupation.Comprehensive and effective measures should be taken to improve the QOL of mothers of children with cerebral palsy and to improve the efficacy of rehabilitation for children with cerebral palsy.

0.05).However,neither CpG-ODN nor hTNF-? failed in improving the expression rates of CD1a.Conclusions CpG-ODN,like hTNF-?,has remarkable im- munostimulatory effect on the differentiation and maturation of monocyte-derived DC from patients with chronic hepatitis B.

Aim To observe the effects of cytokine signaling inhibition protein-3(SOCS3) on the liver fibrosis progression and reverse.Methods C57BL/6 mouse model was established by subcutaneous injection of carbon tetrachloride(CCl4).After a successful model of fibrosis, one-month normal diet was given to induce the reverse fibrosis model, while normal mice of the same gender and weight were as control group.Mice were sacrificed at 1, 2, 3, 4, 5, 6, 7, 8 weeks, respectively, then the liver tissue was harvested for the observation of its injury by hematoxylin and eosin(HE) staining.Then Masson staining was applied for the detection of changes in collagen, and the immunohistochemistry(IHC) for the observation of type Ⅰ Collagen(Colla-1), alpha smooth muscle actin(α-SMA), transforming growth factor beta 1(TGF-β1) and SOCS3 protein expression.In vitro formation of fibrosis was induced by TGF-β1 stimulating HSC-T6 cell lines, which was then reversed by MDI medium, with co-incubation of HSC-T6 cells with plasmid in the process of the reverse.Western blot was employed to detect SOCS3, Colla-1, α-SMA, TGF-β1 expression.Results The expression of SOCS3 and TGF-β1 increased in mouse model of fibrosis with the worsening fibrosis process and decreased in the reverse process.Over-expression SOCS3 in the reverse process reduced the development of liver fibrosis;meanwhile, the expression of TGF-β1 was also reduced accordingly.Conclusion SOCS3 may influence the development of the liver fibrosis and its reverse via regulating the expression of TGF-β1.