Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

Objective:To study the prophylactic effect of combined supine mechanical ventilation supporting the management of esophageal atresia in postoperative complications. Methods:80 patients were selected from January 2015 to June 2016 in the hospital for treatment of congenital esophageal atresia surgery, and divided into control group and observation group with 40 cases each according to the postoperative management method. The control group was treated by holding pillow supine posture and implement routine care, and the observation group was maintained 30o supine mechanical ventilation support management, in order to compare incidence of postoperative complications between them. Results:The incidence of postoperative complications in the observation group was lower than that in the control group (x2=6.03, P<0.05). There was no significant difference between the two groups of children with mechanical ventilation time, HR and MAP levels (t=0.39, t=1.73, t=2.04;P>0.05). The children SaO2 levels in the observation group were significantly higher than that in the control group (t=19.24, P<0.05). The patient care satisfaction rate of observation group was 95.0%, significantly higher than 77.5%in the control group (x2=6.38, P<0.05). Conclusion:It works well for patients with esophageal atresia surgery after using 30o supine intervention and mechanical ventilation support management. It can reduce the incidence of postoperative complications, and should be widely applied.

Objective To analyze the clinical efficacy and safety of laparoscopic and open uterine myomectomy.Methods 160 cases of uterine fibroids diagnosed by our hospital from April 2012 to April 2016 were selected as study cases.The patients were divided into two groups according to the order of treatment.80 patients in the control group received open uterine myoma rejection.80 patients in the observation group received laparoscopic myomectomy.The clinical treatment effect and complication were analyzed.Results The operation time,amount of intraoperative blood loss and the incision size of the observation group were (78.46 ± 10.31)min,(86.24 ±7.65) mL,(25.36 ± 1.28) mm,respectively,which were significantly less than those in the control group,the differences were statistically significant (t =6.57,6.81,7.66,all P ＜ 0.05).The time of postoperative body temperature recovery,time of anal exhaust,time of bedtime and the hospitalization time of the observation group were (24.16 ±3.81)h,(18.29 ± 4.36)h,(11.38± 2.06)h,(4.63 ± 1.51)d,respectively,which were significantly shorter than those in the control group (t =6.25,7.38,7.70,6.27,all P ＜ 0.05).The operative rate and postoperative analgesia rate of the observation group were 6.25％ and 11.25％,respectively,which were significantly lower than those of the control group (x2 =8.33,9.07,all P ＜ 0.05).The incidence rate of postoperative complications was 6.25％ in the observation group,which was significantly lower than 25.00％ in the control group,the difference was statistically significant (x2 =8.65,P ＜ 0.05).Conclusion Laparoscopic myomectomy has the advantages of less trauma,less bleeding,quick recovery and less complication,and high safety.It is the ideal technique for the treatment of uterine fibroids,which is worthy of promotion and application.

Objective:To study the effects of combination of arsenic trioxide and octreotide on the proliferation and apoptosis of hepatocellular carcinoma cells(HCC),and to explore the mechanism of their action on liver cancer.Methods:Heptocellular carcinoma cell SMMC-7721 was treated with arsenic trioxide and octreotide.Cell survival rate was determined by MTT assay;cell cycle and the apoptosis index were determined by flow cytometry (FCM);the morphological changes were observed by transmission electron microscope.Results:The combination of arsenic trioxide and octreotide significantly inhibited the growth of SMMC-7721 and the concentration of each drug in combination is 2.022?mol/L and 8.088?mol/L that was less than single use of arsenic trioxide (3.707?mol/L)and octreotide (22.637?mol/L).The combination of two drugs can arrest HCC in S phases and induce apoptosis.Conclusion:Arsenic trioxide can enhance the antiproliferative effect of octreotide to human HCC and induce apoptosis.

[Objective] To discuss the mechanism of Spina Date Seed Decoction anti-depression.[Method] Take forced swimming and hanging tail to make desperate rats model;take solidity foster and chronic unpredictable mild stimulation to make mice model.Observe mice immobile time;by weight change and spot box test to appraise Spina Date Seed Decoction influence on chronic stress depressed rats behavior change.Take HPLC to measure rats content of monamine neurotransmitters in the brain;compare groups difference with statistics.[Result] The decoction can markedly improve rats mental sportive depression such as interest loss and lowered movement,as well as increasing the content of monamine neurotransmitters.[Conclusion] Spina Date Seed Decoction has anti-depression function,which is related with its increasing 5-HT and NE in the brain.

Pulmonary surfactant is a complex mixture of lipids and surfactant proteins (SP) lining the alveolar surface.In addition to the well established ability of the surfactant system to reduce alveolar surface tension and thereby prevent collapse of the alveoli on expiration,it is also involved in pulmonary host defence.Surfacant protein-A (SP-A),one of the most abundant SP,can deal with various pathogens,using a range of innate immune mechanisms,and links innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization.Surfactant-replacement or increasing SP-A generation might be efficacious for the treatment of inflammatory and infectious diseases in the lung.

MicroRNA (miRNA) is a kind of small non-protein coding RNA and can negatively regulate the expression of target genes at the transcriptional level. In tumors miRNA can act as oncogenes and tumor suppressor genes, and its deregulation in tumors may be a possible reason for tumor progression. Several studies have established the potential usefulness of miRNA as therapeutic targets for tumor metastasis.

Objective: To explore the relation of highly educated professionals’ insomnia,cognitive emotion regulation strategies and negative mood.Methods: 355 staffs from different units in Beijing completed Pittsburgh Sleep Quality Index(PSQI),the cognitive emotion regulation questionnaire(CERQ) and Profile of Mood States-Short Form(POMS-SF).Results: ①Significant positive correlations were found between insomnia and negative mood and catastrophizing,while negative correlations between insomnia and positive refocusing,refocus on planning and positive reappraisal.②Regression analysis indicated predictability of insomnia,catastrophizing,rumination and refocus on planning to negative mood.③Path analysis confirmed the positive and negative cognitive emotion regulation strategies were partial mediators between insomnia and negative mood.Conclusion: Cognitive emotion regulation strategies play important mediating role between insomnia and negative mood.