Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

BACKGROUND:Kirschner wire fixation is the most extensive method to repair metacarpal and phalangeal fractures,but it has some disadvantages such as poor stability and many complications.Present studies suggest that surface rigidity,stability of fracture fragments and fracture healing of mini-plate were better than other fixation methods.Based on anatomical reduction,mini-plate fixation can firmly fix the bone,does not destroy articular surface,so it can restore hand function to the maximum extent.OBJECTIVE:To compare and analyze the therapeutic effects and adverse reactions of Kirschner wire and mini-plate fixation for repair of metacarpal and phalangeal fractures.METHODS:A total of 76 patients with metacarpal and phalangeal fractures,who accepted surgical treatment in Department of Orthopedics,Yixing No.2 People's Hospital from January 2011 to January 2014,were selected.Patients were randomly divided into observation group and control group,with 38 cases in each group.The patients in the observation group (46 places) were treated by mini-plate fixation,while those in the control group (50 places) were fixed with Kirschner wire.Hand function was evaluated after treatment.Healing and complications were compared in both groups.RESULTS AND CONCLUSION:The excelent and good rate in the observation group was 91％(42/46),and 68％(34/50) in the control group,and the significant differences between the two groups were detected (P＜0.05).Total active flexion degree,length of hospital stay and healing time were respectively (147.2±89.6)°,(5.1±2.1) days and (51.4±18.3) days in the observation group,and (132.4±35.3)°,(6.9±2.4) days and (65.5±23.8) days in the control group.Length of hospital stay and healing time were shorter,but total active flexion was greater in theobservation group than in the control group (P＜0.05).Incidence of infection and delayed healing of bone were significantly lower in the observation group than in the control group (P＜0.05).Results suggest that compared with the Kirschner wire,mini-plate fixation for metacarpal and phalangeal fractures can obviously improve hand function,shorten length of hospital stay and healing time.It is safe and reliable,and is one of good clinical treatment options.

Objective To explore the clinical effect and safety of cetuximab plus mFOLFOX6 first-line treatment in k-ras wild type patients with liver metastasis from colorectal cancer.Methods 40 k-ras wild-type colorectal cancer patients with liver metastasis diagnosed by histological detection in our hospital were chosen.20 patients in the observation group were treated with cetuximab plus mFOLFOX6.20 patients in the control group were only given mFOLFOX6.To observe the effect and safety of the two groups.Results RR,operation excision rate and R0 removal rate of observation group (60％,45％,35％) were significantly higher than those of the control group (30％,15％,10％),the differences were statistically significant (x2 =3.95,4.36,4.28,P ＜ 0.05);The PFS of the observation group (16.37 ± 7.24) was higher than (11.52 ± 6.85) in the control group,but the difference was not statistically significant (P ＞ 0.05).In the observation group,there were 2 cases with rash,2 cases of leukopenia,1 case with nausea and vomiting,the incidence rate of adverse reaction was 25 ％ (5/20) ;In the control group,there were 2cases with leukopenia,1 case with nausea and vomiting,there was no rash and paronychia,the incidence rate of adverse reaction was 15％ (3/20),there was no significant difference in incidence rate of adverse reaction between the two groups (P ＞ 0.05).Conclusion Cetuximab combined with FOLFOX6 can improve the performance clinical remission rate and lesion resection rate of k-ras wild type patients with liver metastases from colorectal cancer,and has high safety,which is worthy of clinical application.

Objective To investigate clinical efficacy of the CT guided mixture Danshen injection into the periganglionic space in the treatment of lumbocrural pain.Methods Mixture Danshen infiltrations were performed in 63 patients with lumbocrural pain under CT guidance.Scores of VAS were compared at 3 and 6 months after the therapeutic procedure with evaluation of the efficacy.Results Significant pain reduction was observed in 51 patients (51/63,80.95%),with the score of VAS 7.60± 2.00 (before therapy) dropping to 3.85 ± 1.60 (after 1 month) and 4.05± 1.70 (after 6 month).Differences of VAS scores before and after the therapy were statistically significant.Differences between one-month and three-month follow-up were not statistically significant.Conclusion Mixture Danshen injection around the spinal nerve roots under CT guidance is safe and useful in the treatment of lumbocrural pain.

Objective Anovel index based on frequency-domain analysis of heart rate variability (HRV) was tested on patients with reduced left ventricular systolic function.This index,namely VHFI,was defined as the very high frequency (VHF) component of the power spectrum normalized to represent its relative value in proportion to the total power minus the very low frequency component.Methods Patients (n=130) were divided into a study group,consisting 66 patients with decreased left ventricular systolic function,and a control group,consisting 64 patients with normal heart structure and function and without severe coronary artery stenosis (＜50%).Results VHFI in the study group was significantly higher than that in the control group (19.17±13.35 vs 11.37±10.77,P＜0.001).Cardiac events occurred in 18 patients during follow-up (33.34±3.26 months).Defining the positive test as VHFI =15 and negative test as VHFI ＜15,achieved a sensitivity of 57.58% and a specificity of 78.13% for predicting decreased left ventricular systolic function,and achieved a sensitivity of 66.67% and a specificity of 64.29% for predicting cardiac events.Univariate Cox regression analysis showed that positive VHFI test was an independent variable in predictive cardiac events.Conclusions The results suggest that VHFI is a useful tool for quick evaluation of left ventricular systolic function and prediction of prognosis.

Childhood obesity is a huge problem threatening children's health,which has reached epidemic proportions around the world and is associated with several metabolic and cardiovascular complications.Tolllike receptor 4 is a transmembrane receptor of the innate immune system.Studies have showed that metaflammation reaction mediated by inflammatory signaling pathways of Toll-like receptor 4 is closely related to childhood obesity.In this paper,studies on childhood obesity and TLR4 are reviewed.

The application of analogue associative thinking in literature classification and the application of ana-logue reasoning in CBM and PubMed teaching were elaborated according to their abstractive , obscure , dry and dull contents , which showed that analogue thinking can achieve good results in medical literature retrieval teaching and improve the ability of students to analyze and solve their problems , and their innovative thinking .

Chronic refractory autoimmune thrombocytopenia (C/RITP) comprises complex and heterogeneous pathogenesis.Beyond the classic immune disorders such as platelet autoantibodies and cellular immune imbalance,other important considerations that can cause acquired C/RITP include infection,drug,vaccines,autoimmune diseases,tumor,or platelet function disorder.In addition,advances in the molecular mechanism and genetic correlations of C/RITP for children are also discussed.

Purpose To detect the expression of Nek2, Plk1 and Cdk1 in gastric carcinoma and to explore their correlation with clini-copathological factors. Methods We used immunohistochemistry to detect the protein expression of Nek2, Plk1 and Cdk1 in 80 cases of gastric carcinoma. Results The positive rates of Nek2, Plk1 and Cdk1 expressions in 80 cases of gastric carcinoma were 64%, 79% and 85% respectively. While the positive rates of Nek2, Plk1 and Cdk1 expressions in 20 cases normal gastric tissue were 15%, 10% and 20% respectively,with statistical significance (P<0. 01). There were significant associations between Nek2 expression and differentiation of gastric cancer, invasion depth, lymph node metastasis and TNM stage (P<0. 05). There were no significant associa-tions between Nek2 expression and age, gender and tumor size (P>0. 05). The expression of Plk1 and Cdk1 had a correlation with tumor size, differentiation of gastric cancer, invasion depth, lymph node metastasis and TNM stage (P<0. 05). There were no signifi-cant associations between Plk1 and Cdk1 expressions and age and tumor size (P>0. 05). There were significant associations between Nek2 and Plk1, Plk1 and Cdk1, Nek2 and Cdk1 expression (P <0. 01). Conclusions Abnormal expression of Nek2, Plk1 and Cdk1 might be one of the mechanisms of tumorigenesis, especially of abnormal tumour proliferation. They may represent new potential targets for therapeutic intervention.