Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

Female ; Humans ; Melanosis ; Middle Aged ; Occupational Diseases

Objective To investigate the chnical effect of levonorgestrel-releasing intrauterine system(LNG-IUS) in patients with adenomyosis.Methods A total of eighty patients with adenomyosis were enrolled and underwent LNG-IUS insertion.The degree of dysmenorrhea,amount of menorrhea,size of the uterus,endometrial thickness,hemoglobin as well as hormonal changes and adverse reaction before treatment and after treatment for 3,6,12 months were compared.Results After treatment for3,6,12months,the amount of menorrhea was reduced [(52.4 ± 8.4)％,(22.6 ± 9.8)％,(14.8 ± 8.6)％ vs.(100.0 ±0.0)％],the scores of dysmenorrhea was reduced [(1.2 ± 0.5),(0.8 ± 0.4),(0.3 ± 0.2) scores vs.(2.4 ±0.6) scores],the level of hemoglobin was increased [(104.4 ± 11.4),(109.2 ± 12.6),(118.8 ± 13.4) g/L vs.(88.6 ± 16.5) g/L],the endometrial thickness was thinner [(6.3 ± 1.4),(3.6 ± 0.8),(1.8 ± 0.5) mm vs.(9.2 ± 2.8) mm],the size of the uterus was reduced [(156.8 ± 56.8),(142.4 ± 48.9),(126.6 ± 36.5)cm3 vs.(172.6 ± 62.5) cm3],there was significant difference compared with that before treatment (P ＜ 0.05).After treatment for 3,6,12 months,the levels of folhcle-stimulating hormone,luteinizing hormone and estradiol had no significant difference compared with those before treatment (P ＞ 0.05).After treatment for 3,6,12 months,the level of cancer antigen 125 was significantly reduced compared with that before treatment [(34.6 ± 11.6),(16.6 ± 9.8),(11.7 ± 6.4) kU/L vs.(62.4 ± 24.3) kU/L].Conclusiom The LNG-IUS has exact therapeutic effect in treatment of adenomyosis,and has little influence on ovarian function.It is worth of using in clinic.

Objective To explore the clinical efficacy of ethinylestradiol and cyproterone acetate (Diane-35) combined with mefformin in patients with polycystic ovary syndrome (PCOS).Methods One hundred and sixty patients with PCOS were divided into control group and observation group by random digits table method with 80 cases each.Patients in the control group were given Diane-35 only,while patients in the observation group were given Diane-35 combined with metformin.The triglycerides (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),fasting insulin (FINS),fasting blood glucose (FBG),follicle-stimulating hormone (FSH),luteinizing hormone (LH) and testosterone (T) of patients in the two groups were measured before treatment and after treatment 6 months,the rates of pregnancy and abortion were recorded.Results TC,LDL-C,FINS,FBG,FSH,LHt and T of both the 2 groups after treatment decreased obviously than before treatment,and TG in observation group decreased obviously than before treatment,there were statistical differences (P ＜ 0.05).There was no statistical difference in TG in control group between before treatment and after treatment (P ＞ 0.05).After treatment,TG,FINS,FBG,LH in observation group were lower than those in control group [(1.0 ± 0.2) mmol/L vs.(1.6 ± 0.8) mmol/L,(15.2 ± 6.3) mU/L vs.(18.9 ± 6.2) mU/L,(4.5 ± 1.1) mmol/L vs.(5.1 ± 0.9) mmol/L,(6.3 ± 3.0) U/L vs.(7.4 ± 2.9) U/L],there were statistical differences (P ＜ 0.05).After treatment,the rate of pregnancy in observation group was higher than that in control group [61.2％(49/80) vs.42.5％(34/80)],there was statistical difference (x2 =5.633,P＜ 0.05).The rote of abortion in observation group was lower than that in control group [6.1％(3/49) vs.17.6％(6/34)],but there was no statistical difference (x2 =1.694,P ＞ 0.05).Conclusion The clinical effect of Diane-35 combined with metformin in patients with PCOS is better than Diane-35 only.

Objective To explore different management on malposition of PICC line.Methods 36 PICC line malposition clients,who went through pulling the catheter back,adjusting the position of the insertion limb were not successful,but by using the combination of the following 5 methods can successfully manage the malposition of PICC line:pulling the catheter 1cm back from the commencement point,withdrawing some length of catheter,Changing position,palpating clients' back,practising deep breathing,then X ray to confirm the catheter tip location,record the times and the successful rate.Results Among 36 clients,31 were managed successfully by the first time,3 Clients twice and 2 clients were not successful and had to remove inserted successfully at the basilica vein at the opposite arm.Overall,the successful rate is 94％.Conclusions The combination of the following 5 methods can successfully manage the malposition of PICC line:pulling the catheter 1 cm back from the commencement point,withdrawing some length of catheter,Changing position,palpating clients' back,practising deep breathing.

Objective To explore the influence of shenmai injection on C-reactive protein(CRP) and homocysteine(Hcy) of patients with non-ST-segment elevation acute coronary syndrome.Methods 96 patients with nonST-segment elevation acute coronary syndrome were randomly divided into the control group(48 cases) and the observation group(48 cases).The patients in the control group were treated through the conventional treatment,while the patients in the treatment group were treated by shenmai injection based on the conventional therapy.They were all treated for 14 days.CRP and Hcy were detected before and after treatment.Results The total effective rate of the observation group was 95.8％,which was significantly higher than 87.5％ of the control group (x2 =4.760,P ＜0.05).The plasma levels of CRP and Hcy were all decreased after treatment in both two groups.The CRP and Hcy in the observation group were significantly lower than those in the control group (t =2.927,2.624,all P ＜ 0.05).Conclusion Shenmai injection can significandy decrease the plasma levels of CRP and Hcy in patients with non-ST-segment elevation acute coronary syndrome.

This article discussed basic theoretical issues involved in evaluating the financial governance performance of China's public hospitals.Discussions in it cover such aspects as choice of perspective for evaluating their financial governance performance,scope of financial governance performance evaluation,subjects of finance governance of public hospitals and their responsibilities and objectives,as well as construction of basic dimensions of their financial governance performance evaluation.

This article introduced the public governance theory into the study of financial governance of public hospitals and analyzed the internal logical relations between public governance theory and financial governance study under the framework of public hospital management.These include the present background of financial governance of public hospital and its demand for public governance,public governance theory's applicability and its inspiration in the field of financial governance of public hospitals.The inspirations of public governance theory are as follows:repositioning of government governance responsibility and diversification of governance subjects,synergy of governance structure and shared competency of governance power,as well as the accountability of governance behavior and performance evaluation of governance.

Pancreatic cancer is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis,absence of specific clinical symptoms and signs,prone to metastases and lack of response to conventional therapy.1 year survival rate of this disease increased to about 20 ％ by gemcitabine,but the morbidity and mortality rates are still higher and higher in the whole worldwide.DNA methylation is one of the mechanisms of epigenetics which is the study of heritable changes in gene expression that are not coded in the DNA sequence itself.It seems that DNA methylation indeed plays an important role in the development and progression of pancreatic cancer.