目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

OBJECTIVE:To investigate the characteristics of ADR in our hospital.METHODS:A total of 266 ADR cases reports between 2004 and 2006 in our hospital were collected,which were analyzed statistically by Excel in respect of patients’ sex,age,drug kinds inducing ADR and clinical manifestations.RESULTS:A total of 86 drug kinds were involved in ADR,with hepatobiliary drugs and antiviral drugs showing the highest percentages;56.2% were induced by intravenous route.The major systems involved were skin and its appendants,and central nervous system etc.CONCLUSIONS:Great importance should be attached to the monitoring and reporting of ADR in the clinic so as reduce or avoid the occurrence of ADR.

Objective To discuss the value of user-friendly nursing for CT enhancement scanning. Methods 190 cases were analyzed retrospectively and the nursing experience for high-pressure injector was discussed. Results 185 cases (97.3%) were satisfied with the results and 5 ones (2.6%) were unsatisfied, of which, 4 ones were due to venipuncture. 6 of 190 cases were discomfort, of which 2 ones were with slight allergic reaction, flushed cheeks and urticaria, 2 ones were with psychentonia and fear, and the remaining 2 ones were with hypoglycemia and short breath. Conclusion Proper nursing for application of high-pressure injuector does good to the prevention of allergic reaction.

Objective To investigate the effect and the associated mechanism of Relaxin‐2 in the migration of human vascular smooth muscle cells (VSMCs) .Methods The migration of VSMCs in responsing to Relaxin‐2 was evaluated by using wound heal‐ing assay and transwell assay ,and the cell signaling proteins ,including Akt ,ERK and NF‐κB p65 ,in responsing to Relaxin‐2 were measured by using Western blotting assay .Results Relaxin‐2 can promote the migration of VSMCs in a dose‐dependent manner , NF‐κB inhibitor BAY11‐7082 can block the expression of MMP‐9 and MMP‐2 induced by Relaxin‐2 ,pretreatment with PI3K inhibi‐tor LY294002 and ERK inhibitor U0126 can reduce the activation of NF‐κB p65 induced by Relaxin‐2 .Conclusion NF‐κB p65 could be activated by the activation of PI3K/Akt and ERK signaling pathway induced by Relaxin‐2 ,thereby promoting the expression of MMP‐9 and MMP‐2 ,and inducing VSMCs migration effect .

Acute kidney injury ( AKI) is very common clinical syndrome , which may bring worse outcomes and heavy eco-nomic burden .For nearly one and half centuries , the AKI definition and diagnostic criteria have been continuously evaluating and the diagnostic biomarkers of AKI have been constantly emerging with the development of medicine , which make early diagnosis and early intervention of AKI possible .This review highlights the major studies that the diagnostic and prognostic predictive power of neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, IL-18, livertypefatty acid-binding protein, tissue inhibitor of etalloproteinase-2, and IGF-binding protein 7.The mechanistic relevance of these biomarkers to the pathogenesis and pathobiology of AKI is reviewed in this paper , in order to make an early diagnosis and early treatment for AKI and also improve the prognosis of AKI .

Objective To explore the modern communication tools urged by effect of patients with cor pulmonale discharge rehabilitation program. Methods A retrospective analysis was carried out from February 2014 to October 2016 in 46 cases of patients who suffered heart disease from lung disorders, they were given implementation of rehabilitation nursing through modern communication tools after discharge by the nursing staff. Another 46 cases of cor pulmonale patients were selected as the control group from January 2012 to January 2014, who were given routine rehabilitation treatment after discharge. The treatment effect, lung function and satisfaction degree were compared between the two groups after rehabilitation. SF-36 scale was adopted to assess the patients quality of life. Results The total efficiency was 97.83%(45/46) in the observation group, higher than that of the control group , 86.96%(40/46), the difference was statistically significant (χ2=3.8655,P<0.05). The indexes of pulmonary function of tidal volume, vital capacity, vital capacity, forced expiratory volume in one second of the observation group was (837.47±211.35), (3689.56 ± 174.63), (3788.43 ± 735.34), (1761.24 ± 510.35) ml, the control group were (678.34 ± 184.56), (3089.35 ± 215.35), (2916.36 ± 457.35), (1394.24 ± 394.34) ml, there were significant differences between two groups (t=3.8464-14.6825, P<0.01). The SF-36 scale physiological function, physiological function, mental health, emotional function, body pain, vitality, social function, general health scores of the control group were 77.46 ± 3.46, 74.32 ± 4.25, 72.13 ± 3.46, 77.46 ± 3.67, 75.78 ± 2.74, 79.53 ± 2.15, 80.46 ± 3.15, 78.94 ± 3.47, while they were 87.43 ± 5.23, 88.43 ± 3.47, 85.36 ± 2.36, 89.65 ± 5.36, 88.53 ± 3.48, 90.43 ± 4.36, 90.43 ± 2.35, 89.64 ± 3.27 in the observation group, there was significant difference between two groups (t=10.7831-21.4244, P<0.01). The satisfaction rate of the observation group was 97.83%(45/46), which was significantly higher than that of the control group 82.61% (38/46), and the difference was statistically significant (χ2=6.0348, P<0.05). Conclusions Rehabilitation treatment by the nursing staff through modern communication tools has a very good effect on pulmonary heart disease patients. It can help the pulmonary function of patients recover well, improve the quality of life and satisfaction degree significantly , which should be popularized in clinic.

In order to determine the relationship between hyperacute xenograft rejection and oxygen free radical(OFR)formation,in the model of guinea pig to SD rat cardiac xenotransplantation guinea pig heart specimens were obtained at harvesting,after stored in Ringer's lactate solution(4℃)for 1 hour,and at 60 min after transplantation to assess histological changes and OFR production by light microscopy,electromicroscopy and luminol-enhanced chemiluminescence (LC).OFR formation increased significantlly in hyperacute rejection.These findings suggests that OFR may play important role in the pathogenesis of discordant xenograft rejection.

In an in vivo guinea pig-to-rat cardiac xenotransplantation model,the effect of complement depletion by using Chinese Cobra venom(CCV)on hyperacute rejection(HAR) was evaluated.A single low dose of 0.25～0.5mg/kg CCV given i.P.to SD significantly reduced hemolytic C activity for up to 24 hours.Rats receiving GP cardiac xenografts with CCV therapy min in control rat,P<0.01).Combination therapy using CCV,splenectomy and prostaglandin E1 induced 20~40 hours graft survival.Histologic analysis of GP cardiac xenograft taken from CCV-treated rats revealed monocyte infiltration,extensive hemorrhage and areas of myocardial necrosis 12～40 hours after transplantation.The histologic findings suggested that the monocyte may be involved in delayed xenograft rejection.Our study showed that the complement system plays an important mediating role in the hyperacute rejection in guinea pigs.

Objective To evaluate the effects of angiotensin Ⅱreceptor antagonist (ARB) on expression of plasminogen activator inhibitor(PAI)-1 in the human renal biopsy of patients with chronic kidney disease(CKD)and analyse its clinical significance.Methods PAI-1 expression of 63 specimens with CKD was detected by immunohistochemistry and quantitative analysis was achieved by image analysis system. meanwhile, the patients'clinical data were collected,and PAI-1 expression of 63 specimens with CKD was compared with that of normal renal tissue(19 cases).Results Compared with the normal renal tissue,the expression of PAI-1 in CKD 1,2 and 3 stage wag respectively drastically increased(P<0.05).The expression of PAI-1 in CKD 3 stage was higher than that in CKD 1 and 2 stage(P<0.05).The expression of PAI-1 in the patients treated by valsartan[renal corpuscle(4.73±1.18)%,renal tubule(37.16±6.81)%]was lower than that with no treatment[renal corpuscle(5.81±1.95)%,renal tubule(43.22 ±10.25)%](P<0.05).Conclusions It suggests that the abnormal expression of PAI-1 in CKD play an important role in the progression of glomerular and tubulointerstitiai sclerosis in patients with CKD.ARB may prevent the development of renal inflammation and sclerosis by inhibiting the production of PAI-1.ARB may contribute to the prevention and therapy of CKD.