1.Relationship between serum levels of folic acid and vitamin B12 and depression
Chinese Journal of Clinical Nutrition 2009;17(1):37-40
Objective To investigate the correlation between serum levels of folic acid and vitamin B12 and depression. Methods Thirty patients with depression were selected into depression group whose Hamilton de- pression scale score exceeded 17 and/or Hamilton anxiety scale score exceeded 14. Meanwhile, 30 subjects with- out clinically significant depression were selected into control group. Their serum levels of folic acid and vitamin B12 were determined. Zung Self-rating Depression Scale and Self-rating Anxiety Scale were used to evaluate the depression and anxiety. Results The serum levels of folic acid [ (4. 06±1. 61) vs. (6. 48±2. 36) ng/ml, P < 0. 05 ] and vitamin Bl 2 [ (427.96 126. 20) t . (498.46±119.08) pg/ml, P < 0. 05 ] were significantly lower in depression group than those in control group. No correlation was found between Hamilton depression score and serum folic acid level or vitamin B12 leveL Conclusion Patients with depression have lower serum folic acid and vitamin B12 levels than those of the healthy people.
2.Research progress in animal models of cholangiocarcinoma
Journal of Shanghai Jiaotong University(Medical Science) 2017;37(3):407-410
Cholangiocarcinoma (CCA) is a malignant neoplasm derived from cholangiocytes. The incidence of CCA is only lower than that of hepatocellular carcinoma and ranked the second in liver malignant cancers. The prognosis of CCA patients is poor and most patients will die within a few months after diagnosis. CCA is related to various risk factors, including primary sclerosing cholangitis, cirrhosis, certain chemical agents and liver fluke. Establishment of proper animal models of CCA can not only be helpful for understanding the mechanisms of incidence and development, but also lay a solid foundation for developing novel treatment strategies. Common animal models of CCA include carcinogen-induced models, implantation models, operation models, and genetically engineered models.
3.Medial Collateral Ligament Reconstruction with Semitendinosus Autograft for Medial Instability of the Knee:Report of 12 Cases
Chinese Journal of Minimally Invasive Surgery 2005;0(11):-
Objective To investigate the effect of medial collateral ligament reconstruction using semitendinosus autograft.Methods A total of 12 patients with medial collateral ligament injury received knee examinations.Among them,2 had lateral meniscus injury,and received partial resection of the lateral meniscus;2 had cruciate ligament(CL) injury(anterior CL in one and posterior CL in the other),and underwent bone-ligament-bone reconstruction.Medial collateral ligament reconstruction was performed using the semitendinosus tendon autograft ingrowth in the tibial tunnel.Results Primary healing was achieved in all the cases.In 10 of them,the stability of the knee was regained in 6-month follow-up;stress X-ray examination showed that the medial joint space was smaller than the contralateral one by less than 5 mm,and the position of the interference screw was optimal.Of the 12 patients,11 achieved an active knee flexion between 0? and 120?,the other,who had fracture of the lateral condyle of the femur,had a flexion of 90?.Conclusions Semitendinosus autograft provides sufficient tension for medial collateral ligament reconstruction.The fixation of the knee and the closure of the joint capsule can be achieved by using the method.
4.Progress of percutaneous balloon pulmonary valveplasty application in children with pulmonary valve stenosis
Chinese Journal of Applied Clinical Pediatrics 2017;32(1):77-80
Pulmonary valve stenosis (PS) is a relatively common congenital heart disease,and there are 2 treatment methods of surgical operation and intervention.Percutaneous balloon pulmonary valvuloplasty (PBPV) was applied successfully in children with PS for the first time by Kan.For more than 30 years,with the update of intervention equipment,improvement of operation method and accumulation of clinical experience,the application of PBPV continuously has made new progress.Most of the previous reports of the PBPV were for the immediate and short-term efficacy,while long-term follow-up data and some special types of PS review research were less.Now,combined with PBPV clinical data and long-term follow-up study in recent years,an overview of the application progress of PBPV including indications,methods,curative effect and follow-up,prevention and cure of complications and some special type of PS are provided.
5.Effects of Tsaoko-anemarrhenae Decoction on Apoptosis of the Hippocampal Neurons and it′s Gene Expression in Epileptic Rat Models.
Journal of Medical Research 2006;0(02):-
Epilepsy was arousing the attention of medical circles because of the complexity of its mechanism and the difficulty of its control.The project which used the pioneering research as the basement and was directed by the chinese medicine used the modern multidisciplinary research technologies and explored the mechanism of the brain damage in epilesy.The project′s treatment idea is different from the others,which provided a new way for seeking new medicines for treating epilepsy.The research techniques took use of the application of the behavioral methods and the electrophysiological methods creatively and the subject firstly used this way to observe it dynamically,which greatly improved the accuracy of evaluating the models and pharmacodynamics studies of the epilepsy.The research method of the project firstly observed the changing mechanism of the brain damage and the regulation of the apoptosis related genes,and even the efficiency of tsaoko-anemarrhenae decoction,which enriched the scientific intension of the decoction.The conclusions palyed a very important role in exploiting the new medicine for treating epilepsy and enriching the knowledge of the five visceras in chinese medicine.
7.Protease-activated receptors in periodontitis.
Xia QI ; Ling-xue KONG ; Meng DENG
Chinese Journal of Stomatology 2012;47(12):764-767
Animals
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Cardiovascular Diseases
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etiology
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metabolism
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Humans
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Inflammation
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metabolism
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Periodontitis
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complications
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metabolism
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microbiology
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Platelet Aggregation
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physiology
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Porphyromonas gingivalis
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pathogenicity
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RNA, Messenger
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metabolism
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Receptor, PAR-1
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metabolism
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Receptor, PAR-2
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genetics
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metabolism
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Receptors, Proteinase-Activated
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metabolism
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Receptors, Thrombin
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metabolism
9.A study on relationship between the genetic polymorphisms of angiotensin system and the risk of coronary artery disease
Xinfang LIN ; Meng WANG ; Xiaoming XIA
Journal of Chinese Physician 2000;0(12):-
0.05).The gene frequencies of ACG-T235M and ACE-DD plus AGT-TT were significantly higher in the patients with CAD than in the controls respectively(all P
10.Effect of epidural administration of different combinations of lidocaine, corticosteroids and vitamins on epidural space adhesion and nerve root inflammation in rabbits
Lingjie XIA ; Fanmin MENG ; Wenge SONG
Chinese Journal of Anesthesiology 1996;0(08):-
Objective To compare the effects of epidural administration of different combinations of lidocaine, corticosteroids (dexamethasone, prednisolone) and vitamins(B 1,B 6,B 12 ) on epidural space adhesion and nerve root inflammation in rabbits Methods Forty eight adult Japannese white rabbits of either sex weighing (2 38?0 31)kg were anesthetized with intramuscular ketamine 15 mg?kg -1 and midazolam 0 2 0 3 mg?kg -1 A catheter was inserted into epidural space at L 2 when the ligamentum flavum was exposed by surgery and advanced caudally for 2 3cm Correct placement of the catheter in epidural space was confirmed by injecting 0 5% lidocaine 0 2 ml through the cathter when the animal was awake 24h after epidural cathter placement 0 2ml?kg -1 of normal saline containing talcum power 1mg?ml -1 was injected into epidural space 3 days later the animal were randomly divided into 8 groups: group Ⅰ received no treatment, group Ⅱ epidural normal saline 0 2ml?kg -1 , group Ⅲ epidural 0 5% lidocaine 0 2ml?kg -1 , group Ⅳ epidural compound lidocaine solution 1 (lidocaine 100mg +dexamethasone 10 mg in 20 ml normal saline) 0 2ml?kg -1 , group V epidural compound lidocaine solution 2 (lidocaine 100mg+prednisolone 50 mg in 20 ml normal saline)0 2 ml?kg -1 , group Ⅳ epidural compound lidocaine solution 3 (lidocaine 100mg+dexamethasone 10 mg+vitamin B 1 200mg in 20 ml normal saline) 0 2 ml/kg, group Ⅵ epidural compound lidocaine solution 4 ( lidocaine 100mg+dexamethasone 10 mg+vitamin B 6 200mg in 20 ml normal saline) 0 2 ml/kg, and group Ⅷ epidural compound lidocaine solution 5 (lidocaine 100mg+dexamethasone 10 mg+vitamin B 12 200mg in 20 ml normal saline) 0 2 ml/kg One week later animals were killed by intravenous injection of air Spinal column below L 1 was removed Epidural space and nerve root adhesion was checked first with naked eye then examined under microscope Epidural space adhesion was divided into 4 grades according to Rydell Results 1 Macroscopic examination of epidural space for adhesion: there was no significant different between group Ⅰ and group Ⅱ,Ⅲ, also between group Ⅱ,Ⅲ and group Ⅳ,Ⅴ,Ⅵ,Ⅶ,Ⅷ; there was significant different between group Ⅰ and groupⅣ,Ⅴ,Ⅵ,Ⅵ,Ⅷ (P