Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

[Summary] The prevalence of diabetes mellitus and osteoporosis is rapidly growing and pose a serious threat to human health,. Accumulating evidence indicates that diabetes mellitus is a risk factor for osteoporosis and they could be linked by similar pathophysiological mechanisms. Antidiabetic agents may not only help to control the chronic hyperglycemia state but can also effect bone, This article reviewed the correlation between diabetes mellitus and bone metabolism and summarized the available data on skeletal effects of clinically approved antidiabetic therapies, aimed to provide the basis for clinical medicine use.

As a quantitative evaluation approach for tumor hyperthermia,thermal dosimetry is a critieat part of the treatment planning system and plays a key role in governing the relationships between thermal exposure(temperature and time of exposure)and thermal damage.Its principal theories,parameters as well as thermal dosimetry models are potentially to accurately describe the tumor hyperthermia effectiveness and therefore greatly improve the clinical experience and prescription for tumor hyperthermia.The deep study and wide clinical application of thermal dosimetry in hyperthermia will further standardize tumor hyperthermia and benefit the patients more.

One biocontrol bacillus B3 was isolated from peanut rhizosphere, which showed a broad inhibition spectrum against various soil-borne plant phytopathogenic fungi. It was also found to be capable of utilizing beta-cypermethrin, chlorpyrifos and imidacloprid as the sole source of carbon for growth. The extent of degradation of them at initial concentration of 100 mg/L was 54.42%, 57.44% and 49.24% respectively within 7 days. Strain B3 was identified as Paenibacillus polymyxa based on morphological, physiological-biochemical properties, and 16S rRNA sequence analysis. This study indicated that strain B3 had potential application in biological control and soil bioremediation.

The CHISS statistical software which has its own copyright protection in China is applied to the teaching in medical statistical. A questionnaire was carried out among 135 applicants after they had learnt the modern statistical method for 18 teaching hours and practiced on computers with CHISS for 6 teaching hours. Those applicants gave out the evaluations: CHISS has the character of convenient and visual demonstration. It can meet the needs of medical statistical teaching and doing research.

Henoch Schonlein purpura nephritis is a systemic inflammatory response of systemic vasculitis in anaphylactoid purpura,it is often occurred in childhood with systemic vasculitis reaction.Some patients will develop nephritic syndrome or nephrotic syndrome,even kidney failure,either of which is harmful to the health of children.However,a unified standard for the diagnosis and treatment of purpura nephritis is still lack.Combined with the latest research results,this research intends to review the pathogenesis,clinical diagnosis and treatment of purpura nephritis.

Articles, reviews and proceeding papers published from 2012 to 2015 in medical, chemical and physical journals with the highest IF were retrieved from 2014 JCR and analyzed using the BICOMB software to generate the co-occurrence matrix of authors and plot the map of co-authorship network in medical, chemical and physical fields using the UCINET software.The correlation between the parameters for assessing the importance of co-au-thorship network nodes ( degree centrality, betweenness centrality, closeness centrality, eigenvector centrality) and biblimetric parameters of authors ( number of published papers, frequency of cited papers) was analyzed using the SPSS, which showed that degree centrality, betweenness centrality, and eigenvector centrality were positively corre-lated with the number of published papers and the frequency of cited papers whereas betweenness centrality was negatively correlated the number of published papers and the frequency of cited papers.Betweenness centrality was more significantly correlated with the number of published papers whereas degree centrality was more significantly correlated with the frequency of cited papers.

AIM: To investigate effect of endotoxin on adrenomedulin(ADM) gene transcription in vascular endothelial cells. The role of p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway was also observed.METHODS: The effect of endotoxin in the presence or absence of p38 MAPK specific inhibitor SB203580 on the transcription of ADM in vascular endothelial cells ECV304 was evaluated by reverse transcription nest DNA polymerase chain reaction. RESULTS: Treatments of endotoxin (0.1, 1.0, 10, 50, 100 ?g/L) for 24 h increasea the ratios of ECV 304 ADM mRNA/? actin mRNA. The induction of ADM mRNA by endotoxin could be inhibited partially by 10 mmol/L SB203580.CONCLUSION: Endotoxin stimulated the transcription of ADM gene in vascular endothelial cells. The activation of p38 MAPK might be an important mechanism of ADM gene induced by endotoxin.

There are mounting evidences demonstrating that obesity and osteoporosis pose a daunting threat on global public health problem, given their morbidity and mortality. Ω-3 polyunsaturated fatty acids ,besides as a source of energy, may regulate the cellular signal transduction pathway to produce specific patterns of gene expression, and protect from complications of obesity and osteoporosis . This article reviewed the correlation between obesity and osteoporosis, and summarized the effects and potential mechanism of ω-3 polyunsaturated fatty acids on fat metabolism and bone metabolism from both animal experiments and epidemiological studies.

OBJECTIVE:To investigate the use of antibiotics in patients undergoing hemorrhoidectomy in our hospital.METHODS:A total of 120 copies of discharge records of patients undergoing hemorrhoidectomy written by four doctors(30 copies/doctor) between Jan 2006 and Jun 2006 in proctology department were sampled and divided into four groups in accordance with different charging doctors,and a statistical analysis was carried out in respect of the drug consumption sum and medication data of these patients.RESULTS:The irrational use of antibiotics in patients undergoing hemorrhoidectomy in proctology department of our hospital manifested as unclear indications of medication,improper time of drug use,and the prolonged continuous drug use.There were significant differences among four groups in the average drug consumption sum(P