Objective To explore the clinical effect and safety of cetuximab plus mFOLFOX6 first-line treatment in k-ras wild type patients with liver metastasis from colorectal cancer.Methods 40 k-ras wild-type colorectal cancer patients with liver metastasis diagnosed by histological detection in our hospital were chosen.20 patients in the observation group were treated with cetuximab plus mFOLFOX6.20 patients in the control group were only given mFOLFOX6.To observe the effect and safety of the two groups.Results RR,operation excision rate and R0 removal rate of observation group (60％,45％,35％) were significantly higher than those of the control group (30％,15％,10％),the differences were statistically significant (x2 =3.95,4.36,4.28,P ＜ 0.05);The PFS of the observation group (16.37 ± 7.24) was higher than (11.52 ± 6.85) in the control group,but the difference was not statistically significant (P ＞ 0.05).In the observation group,there were 2 cases with rash,2 cases of leukopenia,1 case with nausea and vomiting,the incidence rate of adverse reaction was 25 ％ (5/20) ;In the control group,there were 2cases with leukopenia,1 case with nausea and vomiting,there was no rash and paronychia,the incidence rate of adverse reaction was 15％ (3/20),there was no significant difference in incidence rate of adverse reaction between the two groups (P ＞ 0.05).Conclusion Cetuximab combined with FOLFOX6 can improve the performance clinical remission rate and lesion resection rate of k-ras wild type patients with liver metastases from colorectal cancer,and has high safety,which is worthy of clinical application.

Pulmonary surfactant is a complex mixture of lipids and surfactant proteins (SP) lining the alveolar surface.In addition to the well established ability of the surfactant system to reduce alveolar surface tension and thereby prevent collapse of the alveoli on expiration,it is also involved in pulmonary host defence.Surfacant protein-A (SP-A),one of the most abundant SP,can deal with various pathogens,using a range of innate immune mechanisms,and links innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization.Surfactant-replacement or increasing SP-A generation might be efficacious for the treatment of inflammatory and infectious diseases in the lung.

Objective To explore the influence of psychosocial factors and depression-anxiety on the intellectual impairment in early period of cerebral infarct.Method We compared the correlation of the occurence of intellectual impairment and depression-anxiety,negative life events among 98 cerebral infarct dementia index cases and 80 cerebral infarct without dementia index cases and 87 control subjects.Result Anxiety states have 74.49％ cerebrol infarct dementia index cases,60％ cerebrol infarct without dementia index cases,and 14.94％ control subjects,Depression states have 74.49％ cerebrol infarct dementia index cases,51.25％ cerebrol infarct without dementia index cases,and 20.69％ control subjects,Negative life events have 78.57％ cerebrol infarct dementia index cases,63.75％ cerebrol infarct witout dementia index cases and 13.79％ contrbl subjects.Conclusion The mood and sensibilities problems of depression anxity(especially of anxity) have a neagative status on the intellegence impirment of cerebral infarct.The correlates of post stroke depression-anxity states analysis were paralysis and position of focal lesion.The negative life events influenced the occuring of intelligence imparement post-cerebral infarct without anxity-depression mood and sensibilities problemes.

OBJECTIVE: A series of Bobath concept, Bobath theoretical hypothesis and clinical practice were summarized, to proVide a better understanding of Bobath concept involved in nervous tissues repairing and functional reconstruction. METHODS: Articles concerning the Bobath treatment for stroke-related literature were retrieved in Highwire press, MEDLINE, and Google from 2001 to 2009, using the key words of "Bobath concept, stroke physical therapy". Data of each study were extracted and analyzed following retrieval. Inclusion criteria:①Bobath concept and its theoretical hypothesis. ②New development of Bobath concept in clinical practice. Exclusion criteria: Repetitive studies. The results of retrieved literatura were analyzed. RESULTS: The theoretical basis of Bobath concept is based on present-day knowledge of motor control, motor learning, neural and muscle plasticity, and biomechanics. The latest theories and viewpoints are rasourced from International Bobath Instructors Training Association and the British Bobath Tutors Association. They expounded on the Bobath concept from linking participation, activities and underlying impairments, organization of human behavior and motor control, the consequences of injury and dysfunction in the execution of movement, neural and muscle plasticity, motor learning and so. This article also discusses several important questions which meet in clinical practice. CONCLUSION: Bobath therapy, as a traditional method for stroke rehabilitation, is constantly absorbing the research results from current neuroscience, psychology and other disciplines, and blended with other treatments to promote the development of neuro-rehabilitation medicine.

Objective To explore the influence of behaviour.individuality-personality factors on the intellectual impairment in early period of cerebral infarct.Methods To compare the correlation of the occurence of intellectual impairment and behaviour individuality among 98 cerebral infarct dementia index cases and 80 cerebral infarct without dementia index cases and 87 control subjects.Results A-type behaviour have 63.27％ cerebrol infarct dementia index cases,47.75％ cerebrol infarct without dementia inedx cases,and 35.63％ control subjects.(EPQ)P >60,63.2％ cerebral infarcl domentia index cases,35％ cerebrol infarct without demcntia index cases,and 20.69％ control subjects.(EPO)N>55,42.86％ cerebrol infaret demcntia index cases,38.75％ cerebrol infarct without dementia index cases and 24.14％ control subjects. Conclusion A type behaviour play on important role on intelligence impairment in post cerebral infact.Psychone drviduality and unsteady mood were manly mood feature of cerebral infarct,especially important post cerebral infarct intelligence impairment.

OBJECTIVE: To bring forward feasible suggestions for Direct-to-Consumer(DTC) marketing of prescription drugs.METHODS: The importance of analysis of DTC marketing of prescription drugs in solving "unrealistically high" drug price because of asymmetric information and its role in sufferers' participating in self-health care were analyzed.The status quo and the problems faced in US DTC marketing were also analyzed.RESULTS & CONCLUSIONS: The marketing of prescription drugs can be extended to the sufferers in China,but we must pay attention to the checkup for DTC advertisement,the time of DTC advertisement being forbidden after the new drugs launched into the market and the scope for DTC marketing.

Objective: To explore the relationship between plasma level of N terminal pro brain natriuretic peptide (NT-proBNP) and severity of coronary artery lesion in patients with coronary heart disease (CHD). Methods: A total of 206 patients suspected CHD, who admitted from Jan 2010 to Jun 2012 in our department and underwent coronary angiography (CAG), were divided into single vessel coronary disease group (n=54), double-vessel coronary disease group (n=52), multi-vessel coronary disease group (n=67) and normal group (n=33), according to CAG examination; and divided into acute myocardial infarction (AMI) group (n=45), unstable angina pectoris (UAP) group (n=91), stable angina pectoris (SAP) group (n=43) and normal group (n=27) according to clinic symptom. All patients received measurement for NT-proBNP, creatine kinase-isoenzyme (CK-MB) and cardiac troponin I (cTnI). Stenotic severity of coronary artery lesion was evaluated using Gensini score method. Data of all groups were analyzed statistically. Results: Compared with SAP group and normal group, there was significant increase in plasma level of NT-proBNP [(2.28±0.22) vs. (2.18±0.69) vs. (2.94±0.24) vs. (2.74±0.15), P<0.01 or P<0.05] in AMI group and UAP group. Compared with normal group, there was significant increase in plasma level of NT-proBNP [ (2.07±0.43) vs. (2.44±0.38) vs. (2.69±0.34) vs. (2.98±0.28), P<0.05] in single, double and multi-vessel coronary disease groups. Plasma level of NT-proBNP was positively correlated with Gensini score (r=0.51, 0.67, 0.73 respectively in single, double and multi-vessel coronary disease group, P<0.05 all). Conclusion: NT-proBNP concentration can be regard as an index predicting severity of coronary artery lesion.

Keratoconus is a relatively common, bilateral, non-inflammatory corneal ectasia characterized by thinning and scarring of the central portion of the cornea,seriously destroyed the vision. The aetiology of this condition is probably multiple factors,such as collagen themry,genetic themry,epithelia themry,etc.Now,recent investigations devote to gene,and think it one of the major aetiological factors. Laboratory studies suggest a role for degradative enzymes and proteinase inhibitors and a possible role for the interleukin-1 system in its pathogenesis, but these roles need to be more clearly defined. It has well-described clinical signs, but early forms of the disease may go undetected unless the anterior corneal topography is studied. Contact lenses are the most common treatment modality. When contact lenses fail, corneal transplant is the best and most successful surgical option.

To meet the requirement of cultivating talented people,the following problems were explored in the medical biochemistry experiments classes including teaching content,teaching format,teaching management,and evaluation of the teaching performance and strengthening of students' capacity cultivation.

The co-metabolic carbon sources,dynamics and influence factors of atrazine biotransformation by genetically engineered microor- ganism(GEM)were investigated in the paper.The results showed that glucose was superior to acetate as co-metabolic carbon sources.The concentration of carbon sources affected little on atrazine transformation but much on GEM growth.The specific transformation rate(STR)of atrazine was influenced not by cell density of GEM but by atrazine concentration.Monod model was used to simulate atrazine transformation dynamics and the parameters were v_(max)=0.168/h and Ks=30.49 mg/L.When temperature reduced,STR decreased markedly.The trans- formation was efficient in weak alkaline condition and was inhibited in acidic condition.To some extent,salinity did not affect transformation activity of GEM.Co~(2+),Fe~(2+),Fe~(3+),and Zn~(2+) improved atrazine transformation,but Mn~(2+),Ni~(2+) and Cu~(2+) inhibited atrazine transforma- tion.The results also showed that there existed a direct correlation between adsorption and transformation of atrazine by GEM.