Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

Fatal Outcome ; Herbicides ; poisoning ; Humans ; Injections, Intramuscular ; Male ; Paraquat ; poisoning ; Young Adult

Female ; Humans ; Melanosis ; Middle Aged ; Occupational Diseases

Objective To investigate the correlation between serum levels of folic acid and vitamin B12 and depression. Methods Thirty patients with depression were selected into depression group whose Hamilton de- pression scale score exceeded 17 and/or Hamilton anxiety scale score exceeded 14. Meanwhile, 30 subjects with- out clinically significant depression were selected into control group. Their serum levels of folic acid and vitamin B12 were determined. Zung Self-rating Depression Scale and Self-rating Anxiety Scale were used to evaluate the depression and anxiety. Results The serum levels of folic acid [ (4. 06±1. 61) vs. (6. 48±2. 36) ng/ml, P < 0. 05 ] and vitamin Bl 2 [ (427.96 126. 20) t . (498.46±119.08) pg/ml, P < 0. 05 ] were significantly lower in depression group than those in control group. No correlation was found between Hamilton depression score and serum folic acid level or vitamin B12 leveL Conclusion Patients with depression have lower serum folic acid and vitamin B12 levels than those of the healthy people.

The application of analogue associative thinking in literature classification and the application of ana-logue reasoning in CBM and PubMed teaching were elaborated according to their abstractive , obscure , dry and dull contents , which showed that analogue thinking can achieve good results in medical literature retrieval teaching and improve the ability of students to analyze and solve their problems , and their innovative thinking .

Objective To explore the influence of shenmai injection on C-reactive protein(CRP) and homocysteine(Hcy) of patients with non-ST-segment elevation acute coronary syndrome.Methods 96 patients with nonST-segment elevation acute coronary syndrome were randomly divided into the control group(48 cases) and the observation group(48 cases).The patients in the control group were treated through the conventional treatment,while the patients in the treatment group were treated by shenmai injection based on the conventional therapy.They were all treated for 14 days.CRP and Hcy were detected before and after treatment.Results The total effective rate of the observation group was 95.8％,which was significantly higher than 87.5％ of the control group (x2 =4.760,P ＜0.05).The plasma levels of CRP and Hcy were all decreased after treatment in both two groups.The CRP and Hcy in the observation group were significantly lower than those in the control group (t =2.927,2.624,all P ＜ 0.05).Conclusion Shenmai injection can significandy decrease the plasma levels of CRP and Hcy in patients with non-ST-segment elevation acute coronary syndrome.

Breast cancer is a hormone-dependent malignant carcinoma. Many well-established studies have shown estrogen receptor , especially estrogen receptor alpha (ERα), play an important role in the development of breast cancer. Recently, increasing evidences have shown that another subtype of estrogen receptor,estrogen receptor beta (ER β), may play an important role in the development of breast cancer. In contrast to the function of ERa, ER β played an anti-proliferation role in cell model and animal experiments of breast cancer. We review the recent articles on the relationship between ERB and invasion and metastasis of breast cancer, the coexpression and interaction among ERβ , ERα and PR.

AIM: To explore the machanism of calcined mica by comparing the difference in crystal structure and inorganic elements of raw mica and calcined ones. METHODS: Crystal structures were compared by IR spectrum and X-ray crystallography and the contents of element in the prevention were determined with ICP-AES. RESULTS: After being calcined,crystal phase transformation changed in gold mica and did not change in white mica.Both of their chemical composition changed,crystal water decreased and crystal defects increased.There were obvious differences in the contents of inorganic elements.The content in white mica was obviously more than that in gold mica.After being calcined,the value of K/Na in white mica decreased and the contents of Ca,Mg increased,while the content of Mg increased and the content of Ca decreased in gold mica. CONCLUSION: There are(actually) many differences in contents of elements and chemical structure in white and gold mica before and after being calcined,which may explain the mechanism of calcined mica.

[Objective]To analyze the characteristics of outpatient prescription drug withdrawal,reduce out-patient drug withdrawal to ensure the safety of patients with medication.[Method]Make statistics on outpatients from January to September of 2007,1292 prescription drug withdrawals,drug withdrawal rate accordingly,drug dosage forms,drug types,the cause of drug withdrawal classification.[Result]There're many pediatric drug withdrawal,injection drug withdrawal,retreat antibiotic drugs,drug withdrawal and the main reason is unreasonable adverse drug reaction.[Conclusion] Analyzing the characteristics of drug withdrawal to strengthen rational drug use can reduce the greatest degree of adverse drug reaction,reducing out-patient drug withdrawal to ensure the drug safe,effective,rational and economic.