Dermcidin (DCD) was found in isolated human skin sweat glands with antimicrobial effect, and was defined as a kind of new small molecule antimicrobial peptide. It was a part of human sweat glands in the skin as the immune system's innate defense. With the studies of DCD, its extensive biological functions are gradually discovered. Since 2010, a number of studies have shown that DCD may be a new risk factor for atherosclerosis. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis and hypertension, platelet aggregation and acute myocardial infarction (AMI). In those experiments, it was also confirmed that aspirin had antagonistic and reverse effects on various biological functions of DCD. Further research on the role of DCD in cardiovascular and cerebrovascular diseases may lead to the prevention, early warning, prognosis evaluation and treatment breakthrough of cardiovascular and cerebrovascular events.

Objective To investigate the predictive value of C-reactive protein(CRP)and serum calcium in the patients with acute pancreatitis(AP).Methods 85 cases of AP in our hospital from January to December 2013 were selected as the study subjects,in-cluding 40 cases of mild acute pancreatitis(MAP)and 45 cases of severe acute pancreatitis(SAP).40 cases of normal volunteers were selected as the control group.The levels of serum calcium and CRP were detected in the three groups by the automatic bio-chemical analyzer and turbidimetric immunoassay.Results The levels of serum calcium in the MAP and SAP groups was on the low side and significantly lower than that in the control group,but which in the MAP group were higher than that in the SAP group,the differences were statistically significant(P <0.05).The level of serum CRP in the MAP group and SAP group was high-er than that in the control group,and which in the SAP group was higher than that in the MAP group,the difference was statistical-ly significant(P <0.05).The level of serum calcium on the third after admission in the MAP and SAP groups was significantlyin-creased compared with the day of admission(P <0.05),but the levels of CRP in the MAP and SAP groups were significantly de-creased,the difference was statistically significant(P <0.05).The CRP detection was more in clinic,but the experiment indicating that simultaneous detection of serum CRP and calcium could significantly increase the accuracy,sensitivity and specificity of clinical judgement,the difference had statistical significance(P <0.05).Conclusion Serum calcium and CRP can be used as the predictive indexes for the condition progression and prognosis of acute pancreatitis and their joint examination can improve the sensitivity,spe-cificity and accuracy of the detection.

Ohjective To know the proper wraping method for postoperative patients with neurosurgical intervention treatment. Methods Divided 94 patients with neurosurgical intervention treatment into the ban-dage group and the gauze group randomly, there were 47 cases in the each group. Bandage and gauze was used in the two groups for punctured wound respectively, and then compared the condition of complications and puncture location between the two groups. Results The incidence rate of puncture-associated comphcations in the bandage group was sinificant lower than that of in the gauze group. Conclusions Wraping by bandage for postoperative patients with neurosurgical intervention treatment is more effective than gauze method.

Objective To understand the situation of prevention and control knowledge and the relevant behaviors about cardiovascular and cerebrovascular disease among community residents in Guangdong Province in order to provide a basis for develop cardiovascular and cerebrovascular disease prevention and control work in the future.Methods Through a randomized sampling method chose community residents participating in cardiovascular and cerebrovascular diseases prevention and control among community residents in Guangdong Province consultation in Guangdong Province seven cities using questionnaire investigation.Results Total 1577 community residents were investigated, of which 50.4% were male, 49.6% female;the cardiovascular and cerebrovascular disease prevention and control knowledge different among the population with different gender, age and region, with statistic significance;according to investigation, 17.1%, 13.5% and 14.9% of the population investigated had the habit of smoking, drinking, and salty badly respectively;50.7% of population had health protection through dietary conditioning, which was 35.4% through the physical training.Conclusion Knowledge awareness situation of cardiovascular and cerebrovascular diseases prevention and control was poor among community residents in Guangdong Province, and risk factors of cardiovascular and cerebrovascular disease existed in the population;health education of cardiovascular and cerebrovascular diseases should be strengthened to change adverse behavior of community residents, develop a healthy and scientific way of life, prevent and control the disease.

With the deepening of the lung cancer molecular biology research,small molecular targets antitumor drugs make breakthrough progress,the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is one of the most attention drug.A series studies show that EGFR-TKI can enhance the antitumor activity of ionizing radiation.Therefore,EGFR-TKI combined with radiotherapy alone for poor-risk patients appears survival benefit,but can't ignore the lung toxicity.However,there is a big contro-versy that EGFR-TKI combined with chemoradiotherapy for locally advanced NSCLC.

Objective To investigate the curative effect of combined traditional Chinese and Western medicine treatment of de-pression after stroke.Methods Patients with depression in 134 cases of cerebral stroke from July 2011 to August 2012 in Tongli-ang People′s hospital were treated in department of internal medicine,and according to the different treatment methods were divided into experimental group and control group,each group of 67 cases.The control group was given paroxetine hydrochloride orally,the experimental group was based on the use of miananning granule in the treatment,obered curative effect of two groups.Results In the experimental group,the control group total effective rate were 95.5%,77.6%.The experimental group total effective rate was significantly better than the control group and has a statistically significance(P<0.05).Conclusion The combination of traditional Chinese and Western medicine treatment of depression after stroke is exact,it is worthy of popularization and application.

Brain Death ; diagnosis ; Breath Tests ; Cerebrovascular Circulation ; Child ; Child, Preschool ; Coma ; diagnosis ; Electroencephalography ; Humans ; Infant ; Infant, Newborn ; Neurologic Examination ; Practice Guidelines as Topic

· AlM: To investigate clinical therapeutic effect and safety of small incision extracapsular cataract extraction combined with intraocular lens implantation in blindness prevention and treatment.
· METHODS: Clinical data of 425 patients with cataract (425 eyes) were analyzed retrospectively, who received small incision extracapsular cataract extraction combined with intraocular lens implantation in the No.413 Hospital of Chinese PLA, with the help from “handicapped rehabilitation engineering in Dinghai District of Zhoushan City” from September 2013 to August 2014.Visual acuity before and after operation, average corneal curvature, corneal astigmatism and intraoperative and postoperative complications were compared statistically and analyzed emphatically.
·RESULTS: ln all of the 425 patients with cataract (425 eyes) , the preoperative best corrected visual acuity of 99 patients were less than 0.05, and the other 326 patients were 0.05 to 0.3.Classification of lens nucleus hardness:level Ⅲ, 63 cases; level Ⅳ, 257 cases; and level Ⅴ, 105 cases.The preoperative average corneal curvature and corneal astigmatism of all patients were 44.6 ±1.52D and 1.35±0.96D.All the 425 patients underwent small incision extracapsular cataract extraction combined with intraocular lens implantation.Postoperative follow-up of 3mo results: the best corrected visual acuity: 5 cases were less than 0.05 (blindness-free rate 98.8%);8 cases were 0.05 to <0.3 ( handicap-overcome rate 96.9%);42 cases were between 0.3 to <0.5;127 cases between 0.5 to 0.8 and 243 cases were ≥0.8.Postoperative average corneal curvature and cornea astigmatism were 44.5 ± 1.42D and 1.47 ±1.00D respectively. There were no statistically significant difference compared with preoperative condition.No severe complications such as infectious endophthalmitis or retinal detachment occurred, except 4 patients ( 0.9%) with posterior capsular rupture and 3 patients (0.7%) with Descemet’s membrane detachment during operation;and 18 patients (4.2%) with transient corneal edema and 4 patients (0.9%) with hyphema after operation.
· CONCLUSlON: lt is effective and safe to apply small incisionextracapsular cataract extraction combined with intraocular lens implantation in blindness prevention and treatment, and it gives excellent visual rehabilitation to cataract patients.Especially in those areas and hospitals having no condition of phacoemulsification, it’s a safe and effective alternative when carrying out the program of blindness prevention and treatment.

Objective: To explore the clinical efficacy and mechanism of auricular point sticking plus Western medicine for moderate gastric cancer pain. Methods: A total of 80 patients were selected and divided into an observation group and a control group according to the random number table method, with 40 cases in each group. Patients in the control group received Western medicine treatment, while patients in the observation group received additional auricular point sticking. Both groups were treated for 2 weeks. Numeric rating scale (NRS) and Karnofsky performance status (KPS) were adopted before and after treatment. The total time and times of flare-up pain in 24 h were recorded. The cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) levels were detected. The clinical efficacy of both groups was evaluated after treatment. Results: The total effective rate of the observation group was significantly higher than that of the control group (P<0.05); after treatment, NRS scores of both groups were significantly lower than those before treatment (both P<0.05), and the score of the observation group was lower than that of the control group (P<0.05); KPS scores of both groups were significantly higher than those before treatment (both P<0.05), and the score of the observation group was higher than that of the control group (P<0.05). After treatment, the total time and flare-up times of pain during 24 h of both groups were significantly reduced (all P<0.05), and those of the observation group were significantly less than those of the control group (both P<0.05). After treatment, the COX-2 and TNF-α levels of both groups were significantly reduced (all P<0.05), and were lower in the observation group than in the control group (all P<0.05). Conclusion: The clinical efficacy of auricular point sticking plus Western medicine for moderate gastric cancer pain is valid. This combined treatment can alleviate cancer pain and improve patients' quality of life, which may be related to its ability to reduce COX-2 and TNF-α levels.

Objective:To observe the signal changes of blood-oxygen-level-dependent functional MRI(BOLD-fMRI)in brain tissue after inhalation of oxygen.Methods:Fifteen volunteers,9 males and 6 females,were included in the present experiment.The fMRI was conducted using 1.5T Singna Double-gradient Super Conducting Magnetic Resonance Imaging system (GE Inc).Bold-fMRI scanning was conducted using GRE-EPI sequence and data analysis was done using SPM2 software. Meanwhile,the BOLD-fMRI T_2 signal changes after 15 s and 6 min inhalation of pure oxygen were observed and compared with those after inhaling normal air.Results:No obvious activation of BOLD-fMRI was observed in the whole brain after inhaling normal air.Fifteen seconds after inhaling pure oxygen,the signal changes in the whole brain mainly manifested as the signal decrease in the gray matter,with average signal change being(-0.041?0.31)% in the gray matter and about(0.056?0.26)% in the white matter;the changes were significantly different from those of the normal air group(P