Pancreatic cancer is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis,absence of specific clinical symptoms and signs,prone to metastases and lack of response to conventional therapy.1 year survival rate of this disease increased to about 20 ％ by gemcitabine,but the morbidity and mortality rates are still higher and higher in the whole worldwide.DNA methylation is one of the mechanisms of epigenetics which is the study of heritable changes in gene expression that are not coded in the DNA sequence itself.It seems that DNA methylation indeed plays an important role in the development and progression of pancreatic cancer.

Newborns,especially premature newborns,because of immature of immune function,have high incidence of sepsis.Today sepsis is still an important cause of neonatal death and poor prognosis.Unfortunately,clinical signs of sepsis are non-specific,so early diagnosis and treatment of the newborn infant with suspected sepsis are essential to prevent severe complications.Blood culture is the gold standard for diagnosis of sepsis,but the positive rote is low.Indicators in diagnosis of sepsis included acute phase reaction proteins,cytokines,cell surface antigen and bacterial DNA testing.This article compares and analyzes the indicators in diagnosis of neonatal sepsis.

0.05).The effective rates of the two treatment schemes were 90%,87%.The cost effectiveness ratio were 108.61 and 76.35.Conclusion Homemade octreotide is better in the treatment of severe acute pancreatitis.

The arteries of the M. latissimus dorsi, gracilis, tensor fasciae latae, gastrocncmius and soleus were studied on 100 Chinese cadavers (40 fetus and babies, 60 adults) by dissection and arteriography. The origin, number, diameter and distribution of these arteries were observed, and were investigated quantitatively by means of MAGISCAN-Ⅰ Image Analyser.Based on the studies of the vascular anatomy of muscles. We classified the arterial distribution into three patterns: Type Ⅰ: The muscle of this group was supplied by one or two main arteries which coursed the entire muscle belly, as in: M. tensor fasciae latae, gastrocnemius, soleus. Type Ⅱ: The muscle of this group had a segmental supply of several arteries, which is distributed partially in muscle belly, as in: M. gracilis, soleus. Type Ⅲ: The musele of this group had a combination of both patterns of vascular arrangement, as in: M. latissimus dorsi, soleus.The muscles of Type Ⅰ and Type Ⅱ could often be divided into several regions which were based on the distribution of each branch of the artery.

Objective To explore the application of HPLC method in the determination of contents of ephedrine hydrochloride in Bidouyan mixture.Methods A HPLC method detected by one wavelength-210 nm for ephedrine hydrochloride had been developed.The chromatographic procedure for determination was carried out using DiamonsilTM C 18 (250mm x 4.6mm,5 μm) as an analytic column gradient eluted with a mixture consisting of acetonitrile and 0.05％ H3PO4.Results The ranges of calibration curve of ephedrine hydrochloride was 0.011 ～ 0.277mg/ml.The established HPLC method was applied to determine 15 samples of Bidouyan mixture.The results showed that the ranges of ephedrine hydrochloride was 0.10 ～ 0.23mg/ml.Conclusion A simple,effective and feasible HPLC method to determine the contents of ephedrine hydrochloride was established for the quality control of Bidouyan mixture.

Relying on the R3 GF program,the present paper attempts to analyze the standards of multi-sectoral social participation projects design and implementation,to construct the key indicators and to explore the experience and bias,as well as to provide recommendations on how to improve performance and outcomes of small grant projects by multi-sectors.

Objective To observe the effect of actovegin on diabetic peripheral neurapathy (DPN).Methods 76 patients with DPN were divided into treatment and control groups at random.Two groups were treated routinely with general treatment on DM and the treatment group was added routine dose of actovegin while the control group were treated with Methycobal.After 8 weeks,the effective rate,MCV and SCV were determined.Results The general effective rate and MCV and SCV in treatment group were higher markedly than control group.Conclusion Actovegin can improve DPN effectively.

Objective To explore the influence of behaviour.individuality-personality factors on the intellectual impairment in early period of cerebral infarct.Methods To compare the correlation of the occurence of intellectual impairment and behaviour individuality among 98 cerebral infarct dementia index cases and 80 cerebral infarct without dementia index cases and 87 control subjects.Results A-type behaviour have 63.27％ cerebrol infarct dementia index cases,47.75％ cerebrol infarct without dementia inedx cases,and 35.63％ control subjects.(EPQ)P >60,63.2％ cerebral infarcl domentia index cases,35％ cerebrol infarct without demcntia index cases,and 20.69％ control subjects.(EPO)N>55,42.86％ cerebrol infaret demcntia index cases,38.75％ cerebrol infarct without dementia index cases and 24.14％ control subjects. Conclusion A type behaviour play on important role on intelligence impairment in post cerebral infact.Psychone drviduality and unsteady mood were manly mood feature of cerebral infarct,especially important post cerebral infarct intelligence impairment.

Objective To observe effect of Rho kinase inhibitor combined with hyperbaric oxygen on the recovery of neurological function after spinal cord injury in patients with thoracolumbar fractures.Methods A total of 80 cases of thoracolumbar fractures combined with spinal cord injury patients as the research object, the packet by the standards of admission of single and double serial number, odd numbers were divided into control group, even number were divided into treatment group (40 cases in each group); two groups underwent surgical treatment, control group was given single usage fasudil treatment, treatment group was given hyperbaric oxygen therapy for auxiliary therapy on the basis of control group, Continuous treatment for two months.Compared neurological function scoring, grading, blood superoxide dismutase (SOD) , epithelial growth factor (EGF) , lipid peroxide (LPO) and adverse reactions pre-and post-treatment between two groups of patients.Results After treatment,total effective rate of treatment group (92.50%), ASIA sensory, movement scores were significantly higher than control group (75.00%)(P<0.05);Content of SOD and EGF of treatment group were significantly higher than control group(P<0.05);the adverse reaction rate (12.50%) was significantly lower than that of control group (32.50%)(P<0.05).Conclusion Rho kinase inhibitor combined with hyperbaric oxygen can significantly improve the degree of injury, neurological function and blood SOD, EGF, LPO content in patients with lumbar vertebral fractures combined with spinal cord injury, and the adverse reactions are few, has definite clinical effect.

Papers on medical information system published in 16 medical journals in 2013 JCR with their IF≥1 were retrieved from Web of Science(2010-2014).Social network analysis and co-word analysis of their high fre-quency key words showed that efficiency of medical information system implementation, acceptance behaviors of medical information system users, mining of medical data, application of medical information system in medical sci-ences, and application of decision support system in medical sciences were the hotspots in papers on medical infor-mation system.The authors pointed out that electronic health records, medical information system management, and application of emerging information technology in medical information system were still the study hotspots in the coming years.