120 casea of bronchogenic carcinoma treated 286 times by BAI revealed several types of bronchial arterial variations in 12 cases and multiple feeding arteries in 56 cases by way of selective Bronchial arteriography.The article emphasizes the significance of the existence bronchial arterial anomalies and multiple feeding arteries in BAI.And also we ex plored the selective catheterization technique in the bronchial arteriography.

Objective To investigate the biodistribution and positron emission tomography (PET) imaging of 3′-deoxy-3′-~ 18 F-fluorothymidine (~ 18 F-FLT) in a murine model of pulmonary carcinoma, and to evaluate the use of ~ 18 F-FLT as a new PET tracer for diagnosis of pulmonary malignant tumor. Methods 40 T739 mice bearing the pulmonary adenocarcinoma were randomly divided into five groups according to different tracers and time after their injection (n=8/group). The biodistribution of mice for ~ 18 F-FLT was measured with well-gamma detector at 30min, 60min, 90min, 120min after injection via the tail veins. The biodistribution of mice for ~ 18 F-FDG was examined at 60min after injection as controls. In addition, the PET imaging of mice was performed using two tracers. Results In the biodistribution study of ~ 18 F-FLT, considerable radioactive uptake in tumor was observed, and high radioactivity was showed in the kidney and spleen. The T/NT ratios of tumor/blood, tumor/muscle and tumor/lung was all above 2.0. The tumor PET images with ~ 18 F-FLT were clear, as well. Conclusions The uptake of ~ 18 F-FLT in pulmonary adenocarcinoma is higher than that in normal tissues, thus the pulmonary neoplasm could be identified accurately with PET imaging. Our preliminary study of ~ 18 F-FLT in lung carcinoma xenografts is satisfactory, and it provides a basis for further clinical study.

Objective To discuss the curative effect and safety issues of Telsartan(Micardis) and Valsartan (Diovan) Capsule in curing light and to moderate essential hypertension patients. Methods The 126 light or moderate essential hypertension patients were divided into two groups randonly:63 patients in Micardis group(80mg qd)and 63 patients in Diovan group(160mg qd). The courses of treatment of each group were 8 weeks. The medicine was taken by patients after breakfast everyday. Data of blood pressure, heart rhythm, blood and urine routine test, hepatic and renal function, blood biochemistry test, ECG and side effects was recorded everyday before and after the treatment. Results After 8 weeks treatment, the average SBP of blood pressure was reduced from ( 156.3 ± 13.3 ) mm Hg to(128.6 ± 10.9) mm Hg(Micardis group)and (129.3 ± 11.3) mm Hg(Diovan group). The average DBP was reduced from(98.3±11.6) mm Hg to(80.3±7.1) mm Hg(Micardis group)and(80.6 ±7.3) mm Hg(Diovan group). The blood pressure of both group had notable decreasing after taking medicine(P ＜ 0.01). The total effective rates were 79.36% and 73.02%. In the same term,the curative effect of both group have significant difference(P＜0.05). In Micardis group,total Cholesterol(TC) level reduced from(5.6 ± 1.2) mmol/L to( 4.9 ± 1.1 ) mmol/L; Triglyceride (TG) level reduced from (2.38 ± 0.31) mmol/L to (2.23 ± 0.33) mmoL/L; Low Density Lipoprotein Cholesterol(LDL-C) level reduced from( 3.26 ± 0.38 ) mmol/L to( 2.89 ± 0.46 ) mmol/L; High Density Lipoprotein Cholesterol (HDL-C) level increased from ( 1.3 ± 0.6 ) mmol/L to ( 1.5 ± 0.3 ) mmol/L. As comparison, in the Diovan group only the TC level reduced from (5.6 ± 1.2) mmol/L to(5.2 ± 1.3) mmol/L. Both groups did not have significant adverse reactions. Conclusion As the Angiotensin Ⅱ Receptor Antagonist ( ARA), both the Telsartan and Valsartan Capsule were effective medicines in curing light and moderate essential hypertension patients. These two medicines which were reliable and safety,had good tolerance and few side effects. However,Telsartan had better effects than Diovan in reducing blood pressure and triglyceride on light or moderate essential hypertension patients. Also, Telsartan had longer half-life period(18-24h) and lower price.

Novel optical materials are crucial for environmental monitoring. Metal nanoclusters ( metal NCs) , typically consisting of several to tens of metal atoms, have attracted more and more attention for recent years. Due to their ultrasmall size, strong fluorescence, low toxicity, excellent stability and unique core-shell structure, metal NCs have been considered as promising optical materials for the construction of excellent fluorescent sensors. In this review, we mainly focus on the recent progress in their applications in environmental monitoring, including the detection of pH, heavy metal ions, inorganic anions and nitroaromatic explosives.

Objective To explore the clinical manifestation and laboratory examination of chronic diarrhea in children with acquired immunodeficiency syndrome(AIDS) and analyze the reasons that causes the chronic diarrhea in children.Methods Clinical data of 7 patients (male 4 cases,famale 3 cases)with AIDS with manifestation of chronic diarrhea among the 17 cases were diagnosed as AIDS in Beijing children′s hospital from Jan.1999 to Dec.2006.The time of diarrhea,degree of dinrrhea,characteristic of stool,accompaniment symptom,laboratory examination were retrospectively analyzed.Results The average onset age was 6 years old(from 2-9 years old).The average time of diarrhea was 6 months(from 1-16 months).Four cases main complained with chronic diarrhea,3 cases came to the hospital because of fever,cough and wasting;6 cases with diarrhea,7 cases with malnutrition and anemia,5 cases accompanied hypokalemia and metabolic acidosis,6 cases had delay in growth and development,2 cases with abnormal stool routine exam,1 case with positive stool culture of fungi.All patients were with lower CD4,5 cases with lower CD4/CD8.Conclusions Chronic diarrhea is a common symptom in children with AIDS,and usually accompanied by obvious delay in growth and development,malnutrition and anemia,the reasons that causes the chronic diarrhea are consi-dered to be related with both the opportunistic infection and HIV infection.

Objective To obtain a single toxin component from the jellyfish Cyanea capillata and provide a foundation for the further study on bioactivity and function of the serine proteases from C.capillata.Methods Primers designed with restriction enzyme were used to amplify the coding region of cDNAs (CcSP1, CcSP2 and CcSP3).PCR fragments were ligated with the pET-24a( +) vector to construct the recombinant plasmids (pET24a-CcSP1, pET24a-CcSP2 and pET24a-CcSP3).After screening and identification,the recombinant plasmids were transformed into the Rosetta (DE3).plysS for protein expression.After induction with IPTG, SDS-PAGE and Western-blot were used to detect the expression of the recombinant proteins.Results SDS-PAGE showed that the proteins of rCcSP1, rCcSP2 and rCcSP3 were expressed in a single band at about 34 kDa, 42 kDa and 42kDa, respectively.Western-blot detection with anti-His antibody further confirmed that these recombinant proteins were His-tagged CcSP1, CcSP2 and CcSP3 fusion protein were obtained.Conclusion Prokaryotic recombinant plasmids of C.capillata serine proteases are contructed and recombinant proteins are obtained, which establishes the foundation for future study on the function of serine proteases from jellyfish.

Adolescent ; Adult ; Altitude ; Extremities ; physiology ; Humans ; Male ; Memory ; physiology ; Motor Activity ; physiology ; Movement ; physiology ; Young Adult

Altitude ; Humans ; Oximetry ; Oxygen ; administration & dosage ; therapeutic use ; Oxygen Inhalation Therapy ; instrumentation

Acclimatization ; physiology ; Adolescent ; Altitude ; Humans ; Male ; Nitric Oxide ; blood ; Nitric Oxide Synthase ; blood ; Oxygen ; physiology ; Pulmonary Gas Exchange ; Young Adult