Objective To investigate the clinical characteristics of upper gastrointestinal diseases in very old people (aged ≥ 90 years),and to explore the necessity and safety of the gastroscopy for the super elderly people.Methods Clinical data of 50 very old people were retrospectively analyzed.Results The total detection rate of upper gastrointestinal disease was 76.0％ (38/50),in which the reflux esophagitis (RE) was the most common (26.0％),followed by erosive gastritis (20.0％),atrophic gastritis (18.0 ％),peptic ulcer (12.0 ％),gastrointestinal cancer (10.0％),duodenitis (8.0％) and fundic gland polyps (6.0％) respectively.RE lesions detected by gastroscopy were mainly mild and were divided into endoscopic grade LA-A (46.1％),LA-B (30.8％),LA C (7.7％),and LA-D (15.4％) according to the Los Angeles classification.The most common symptoms were abdominal distension and anorexia,and the both incidences were 12.0％.There was no significant difference in the prevalence of clinical symptoms between the elderly people with upper gastrointestinal disease and without abnormal gastroscopic findings [44.7％ (17/38) vs.41.7％ (5/12),x2 =0.035,P＞0.05].22 patients (44.0％) underwent gastroscopy under intravenous anesthesia.Conclusions The incidence of upper gastrointestinal disease is high in very old people,and mild reflux esophagitis is the most common.Clinical symptoms are little or asymptomatic in most very old people.Gastroscopy under intravenous anesthesia is safe and feasible for the very old people.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Panic Disorder ; psychology ; therapy ; Treatment Outcome

Epigenesis, Genetic ; Humans ; Nervous System Malformations

Epilepsy ; genetics ; Ion Channels ; genetics

Child ; Congresses as Topic ; Humans ; Pediatrics

OBJECTIVETo study the MRI features of proximal femur bone marrow edema syndrome for further improve the understanding of the disease.

METHODSMRI imaging of 10 patients with proximal femur bone marrow edema syndrome was retrospectively reviewed,including 6 males and 4 females with an average age of 41.5 years old ranging from 36 to 57. The courses of diseases ranged from 1 week to 3 months. Among them, 9 cases had clinical manifestations of sudden hip pain, 7 cases had limited ability of walking and hip movement;all patients had no obvious injury history, non of the female patients was pregnant. All patients were followed up from 3 to 12 months, the following-up were topped after MRI when the symptoms disappeared for 3 months.

RESULTSThe MRI demonstrated diffuse bone marrow edema involving the femoral head, neck and the inter-trochanteric region, 13 hips of 10 patients with bone marrow edema included 6 cases in grade 1, 5 cases in grade 2,2 cases in grade 3; 9 hips with hip hydrarthrosis included 6 hips in grade I ,1 hip in grade II, 2 hips in grade III. After treatment for 3 to 12 months the hip symptoms of the patients disappeared and MRI images were normal.

CONCLUSIONMRI is useful in defining the location and extent of proximal femur bone marrow edema syndrome.

Adult ; Bone Marrow Diseases ; diagnosis ; pathology ; Edema ; diagnosis ; pathology ; Female ; Femur ; pathology ; Humans ; Magnetic Resonance Imaging ; methods ; Male ; Middle Aged ; Syndrome

Dilatative arteriopathy is also called Dolichoectasia, presenting as enlarged ,tortuous ,and dilated arteries; especially with involvement of intracranial arteries. The incidence of dolichoectasia is quite low, but it may induce recurrent strokes with poor prognosis and up to now there is no specific management. Our study reviews the potential etiology, epidemiology, symptoms, pathophysiology, prognosis and present status of treatment for dolichoectasia.

MicroRNAs are one kind of endogenous noncoding small-molecular RNAs,which play an important role in regulating gene expression,cell proliferation and differentiation and a series of life activity.Hepatocellular carcinoma is a common malignant and life-threatening tumor with a high incidence and low 5-year survival rate.In recent years,the results of researches show that microRNAs in hepatocellular carcinoma have the function of oncogenes or tumor suppressor genes as well as having a close relationship with the occurrence,progression,diagnosis,treatment and prognosis of hepatocellular carcinoma.

Endovascular coil embolization is the first primary technique of choice for treating intracranial aneurysms in many centers around the world ,but some patients still got recanalizations months later,that may lead to death or severe disability just as the same in neurosurgery. This review showed the technic details of the first generation of Matrix bioabsorbable poly-meric material coil ,and analyzed clinical results among many treatment centers,involving the therapeutic measure of intracranial aneurysms.

Objective To evaluate the feasibility of combined application of helicobacter pylori stool antigen(HpSA)-and traditional serology in epidemiologic study of helicobacter pylori(Hp) infection in children. Methods Hp serum IgG antibodies were examined among 480 healthy children. Heticobacter pylori stool antigen(HpSA) were measured among children who were seropositive. Hp status was defined as positive when stool antigen test was positive, Hp status was defined as negative when seronegative. A case - control study was conducted to identify risk factors of Hp infection in preschool children. Results Among 480 preschool children, 172 (35 8 %) were sero- positive, 64(13.3 %) with positive result of HpSA test were diagnosed as current Hp infection. Univariate factor analysis demonstrated that Hp infection clustered in families and Hp infection was often acquired in childhood by oral-oral and fecal - oral person to person transmission. Conclusions HpSA and serology screening are two nomnvasive tests, simple not costly, effective and accurate. The combination of these 2 noninvasive methods can be applied in epidemiologic study of Hp infection in childrenJAppl Clin Pediatr,2004,19(11):948-950