1.Methods for Determination of Four Nitro Alkances in the Air of Workplace
Ming ZHAN ; Ye XI ; Jingliang XU
Journal of Environment and Health 1992;0(05):-
Objective To develop the methods for determination of nitromethane,nitroethane,1-nitropropane,2-nitropropane in the air of workplace. Methods Nitromethane,nitroethane,1-nitropropane,2-nitropropane in the air of workplace were collected by active carbon tube,desorbed in ethyl acetate solution and detected by capillary gas chromatography (GC-FID). Results The linear concentration range of nitromethane,nitroethane,1-nitropropane,2-nitropropane was 43.2-345.3,177.6-1 421.0,68.5-547.7,24.1-192.4 ?g/ml respectively and the relative standard deviation was 1%-5%. Sampling efficiency was 100%,desorption efficiency was 91%-93%. The sample could be resaved at 4-10 ℃ for 5-7 days. Conclusion The method is applicable to determination of nitromethane,nitroethane,1-nitropropane,2-nitropropane in the air of workplace.
2.Advanced in solubilization methods of water-insoluble natural drugs.
Hui ZHONG ; Yuan ZHU ; Jiang-nan YU ; Xi-ming XU
China Journal of Chinese Materia Medica 2014;39(17):3226-3231
With the development of natural products, the research activities on the solubilization methods of water-insoluble natural products have been carried out worldwide. Big molecular weight and poor solubility of most natural active ingredients lead to a very poor oral absorption and low bioavailability, which has extremely limited their development in pharmaceutical fields and clinical application. As a result, it is necessary to find out a suitable technique to improve the solubility and enhance the oral bioavailability of insoluble natural drugs. Based on the related references published in these years, this review introduced some new techniques to improve the solubility and bioavailability of natural drugs, including prodrugs, inclusion complex, solid dispersion, cocrystals, osmotic pump, liquisolid compacts, micronization, self-microemulsifying, nanosuspensions, lipsomes, polymeric micelles and so on, and summarized the theory, characteristics, application range, application examples, problems and development direction of each technique.
Administration, Oral
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Biological Availability
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Biological Products
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administration & dosage
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chemistry
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pharmacokinetics
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Chemistry, Pharmaceutical
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methods
;
trends
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Solubility
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Technology, Pharmaceutical
;
methods
;
trends
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Water
3.Clinical research on advanced liver cancer treated with percutaneous RFA cool-tip electrode under ultrasound guidance
Shixi CHENG ; Guowen YING ; Weidong XU ; Wei XI ; Ming ZHANG
Journal of Interventional Radiology 1992;0(01):-
Objective To evaluate the clinical efficacy and complications in the treatment of advance liver cancer under ultrasound guidance with percutaneous RFTI-1 TM-cold cycle RF tumor ablation apparatus produced by Nangjing TianMa high-tech Company limited. Methods 25 patients of advance liver cancer, including 8 cases of metastatic liver cancer, 17 of primary hepatic carcinoma, were treated with percutaneous RFA cool-tip electrode under Ultrasound guidance 1 to 2 times. Eight of the patients prior to RFA were treated with TACE of individually three times for each. The postoperative efficacy was evaluated by enhanced CT. Results 10 lesions were completely necrotized and the majority parts of another 15 lesions were also under necrosis. Follow-up of six months, all patients are still alive with marked improvement of life quality. Conclusion The short-term efficacy of percutaneous Ultrasound-guided RFA with cool-tip electrode for treating advance liver cancer is quite satisfied, worthy to be recommended.
4.Research progress of in vitro and in vivo anti-tumor effects and formulation of bufalin.
Ying XU ; Mei CHEN ; Xue-Feng JIN ; Chen QIAN ; Xi-Ming XU ; Xuan ZHANG
China Journal of Chinese Materia Medica 2014;39(15):2829-2833
Bufalin is an active compound of the traditional Chinese medicine Chansu, which exhibits significant anti-tumor activities in many solid tumors and leukemia cell lines. Bufalin could introduce apoptosis, reverse drug-resistance, and prevent migration and invasion of tumor cells. This paper reviewed the latest research progress of the in vitro and in vivo anti-tumor effect and mechanism of bufalin on a series of cancers, such as hepatocellular carcinoma, lung cancer, colon cancer, gastric cancer, leukemia, bladder cancer, and its formulation study is also summarized for the reference of its further study and application.
Animals
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Antineoplastic Agents
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chemistry
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pharmacology
;
therapeutic use
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Bufanolides
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chemistry
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pharmacology
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therapeutic use
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Chemistry, Pharmaceutical
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methods
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Neoplasms
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drug therapy
;
pathology
5.Recent development of natural and reconstituted lipoprotein based nano drug delivery vehicles.
Ying XU ; Xue-Feng JIN ; Qi-Neng PING ; Hong-Fei LIU ; Mei CHEN ; Xi-Ming XU
Acta Pharmaceutica Sinica 2014;49(1):23-29
Lipoproteins are biological lipids carriers. The natural and reconstituted lipoprotein based drug delivery systems have been extensively developed in recent years. This article reviews the development of natural and reconstituted low-density lipoprotein and high-density lipoprotein based vehicles in the antitumor area.
Animals
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Antineoplastic Agents
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administration & dosage
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chemistry
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Apolipoproteins B
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administration & dosage
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chemistry
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Drug Carriers
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administration & dosage
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chemistry
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Humans
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Lipoproteins
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administration & dosage
;
chemistry
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Lipoproteins, HDL
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administration & dosage
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chemistry
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Lipoproteins, LDL
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administration & dosage
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chemistry
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Nanoparticles
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Neoplasms
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drug therapy
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Peptides
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administration & dosage
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chemistry
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Pharmaceutical Vehicles
;
chemistry
6.Study of effects of complex aerobatics on serum insulin, cortisol and angiotensin II.
Ming Gao LI ; She Zhen QIN ; Gui Xi MA ; Lang En XU ; Xin Hua ZHANG
Korean Journal of Aerospace and Environmental Medicine 1993;3(1):112-118
No abstract available.
Angiotensin II*
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Angiotensins*
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Hydrocortisone*
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Insulin*
7.Influence of complex aerobatics on serum gastrin level of pilots.
Gui Xi MA ; She Zhen QIN ; Ming Gao LI ; Lan Gen XU ; Xin Hua CHANG
Korean Journal of Aerospace and Environmental Medicine 1993;3(2):71-72
No abstract available.
Gastrins*
8.Nanoscale drug carriers for traditional Chinese medicine research and development.
Cheng-xue YI ; Jiang-nan YU ; Xi-ming XU
China Journal of Chinese Materia Medica 2008;33(16):1936-1940
Nanocarriers generally made of natural or artificial polymers ranging in size from about 10-1 000 nm, possess versatile properties suitable for drug delivery, including good biocompatibility and biodegradability, potential capability of targeted delivery and controlled release of incorporated drugs, and have been extensively used in the development of new drug delivery systems (DDS). These types of nano-DDS have considerable potential to traditional Chinese medicine (TCM), and recently have attracted increasing efforts on the TCM research and development. In this review, the recently published literature worldwide is covered to describe the latest advances in the applications as TCM delivery carriers, and to highlight the characteristics and preparation methods of some selected examples of promising nanocarriers such as nanoparticles, lipid nanoparticles, nanoemulsions, nanomicelles and nanoliposomes.
Drug Carriers
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chemistry
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Medicine, Chinese Traditional
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methods
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Nanostructures
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chemistry
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Nanotechnology
;
methods
9.Advances in research of pharmacological effects and formulation studies of linalool.
Dong-mei JIANG ; Yuan ZHU ; Jiang-nan YU ; Xi-ming XU
China Journal of Chinese Materia Medica 2015;40(18):3530-3533
Linalool, as a major volatile compound, is widely distributed in natural plant essential oil. In addition, it can also be artificially synthesized. Linalool is used frequently as an important ingredient of perfumes and household detergents. It is still employed in food flavor and industries. Besides, linalool has some positive effect on healthcare. Many studies have showed that linalool exhibited a variety of pharmacological activities, including analgesic, anxiolytic, sedative, anti-inflammatory, anti-tumor and anti-bacterial effects. Therefore, linalool will be a promising agent for clinical application. This article reviews the pharmacological effects and formulation studies of linalool so as to provide a theoretical basis for its further development and utilization.
Animals
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Anti-Anxiety Agents
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chemistry
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pharmacology
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Anti-Inflammatory Agents
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chemistry
;
pharmacology
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Chemistry, Pharmaceutical
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Drugs, Chinese Herbal
;
chemistry
;
pharmacology
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Humans
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Hypnotics and Sedatives
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chemistry
;
pharmacology
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Monoterpenes
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chemistry
;
pharmacology
10.Progresses in screening active compounds from herbal medicine by affinity chromatography.
Ying-shu FENG ; Shan-shan TONG ; Xi-ming XU ; Jiang-nan YU
China Journal of Chinese Materia Medica 2015;40(6):1032-1037
Affinity chromatography is a chromatographic method for separating molecules using the binding characteristics of the stationary phase with potential drug molecules. This method can be performed as a high throughput screening method and a chromatographic separation method to screen a variety of active drugs. This paper summarizes the history of affinity chromatography, screening technology of affinity chromatography, and application of affinity chromatography in screening bio-active compounds in herbal medicines, and then discusses its application prospects, in order to broaden applications of the affinity chromatography in drug screening.
Animals
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Chromatography, Affinity
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methods
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trends
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Drug Evaluation, Preclinical
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methods
;
trends
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Drugs, Chinese Herbal
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chemistry
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isolation & purification
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pharmacology
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Humans
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Plants, Medicinal
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chemistry