2.Antagonism of vecuronium-induced residual neuromuscular blockade with neostigmine
jia-qian, ZHOU ; xi-ming, CHEN ; ying-wei, WANG
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(02):-
0.05). Conclusion When TOFR recovers to 0.55,antagonism of residual neuromuscular blockade is still necessary.Different doses of neostigmine may antagonize vecuronium-induced residual neuromuscular blockade,and lower dose of neostigmine(10-20 ?g/kg) is recommended.
3.Comparison of surface marker of monocyte-derived dendritic cells between cord blood and adult peripheral blood
ji-hong, QIAN ; tong-xin, CHEN ; xi, WANG ; ying-ying, JIN ; jian-xing, ZHU
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(10):-
0.05).The percentage of CD40 positive cells in CBMC-derived DC was lower than that in PBMC-derived DC[(34.80?7.77)% vs(54.37?9.57)%,P
4.A new flavonoid glycoside from leaves of Eucalyptus robusta.
Xi-feng GUAN ; Qian-yi GUO ; Xiao-jun HUANG ; Ying WANG ; Wen-cai YE
China Journal of Chinese Materia Medica 2015;40(24):4868-4872
A new flavonoid glycoside, (-)-2S-8-methyl-5,7,4'-trihydroxyflavanone-7-O-β-D-glucopyranoside (1), along with five known ones, quercetin-3-O-(2"-galloyl)-α-L-arabinoside (2), kaempferol-3-O-α-L-arabinoside (3), guaijaverin (4), trifolin (5) and hyperin (6), was isolated from the leaves of Eucalyptus robusta. Their structures with absolute configurations were elucidated by NMR, HR-ESI-MS, CD spectra data and physicochemical methods. In addition, 2-6 were isolated from E. robusta for the first time.
Eucalyptus
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chemistry
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Flavonoids
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chemistry
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isolation & purification
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Glycosides
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chemistry
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isolation & purification
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Plant Leaves
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chemistry
5.Research progress of in vitro and in vivo anti-tumor effects and formulation of bufalin.
Ying XU ; Mei CHEN ; Xue-Feng JIN ; Chen QIAN ; Xi-Ming XU ; Xuan ZHANG
China Journal of Chinese Materia Medica 2014;39(15):2829-2833
Bufalin is an active compound of the traditional Chinese medicine Chansu, which exhibits significant anti-tumor activities in many solid tumors and leukemia cell lines. Bufalin could introduce apoptosis, reverse drug-resistance, and prevent migration and invasion of tumor cells. This paper reviewed the latest research progress of the in vitro and in vivo anti-tumor effect and mechanism of bufalin on a series of cancers, such as hepatocellular carcinoma, lung cancer, colon cancer, gastric cancer, leukemia, bladder cancer, and its formulation study is also summarized for the reference of its further study and application.
Animals
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Antineoplastic Agents
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chemistry
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pharmacology
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therapeutic use
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Bufanolides
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chemistry
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pharmacology
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therapeutic use
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Chemistry, Pharmaceutical
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methods
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Neoplasms
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drug therapy
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pathology
6.Study of ceiling effect of commonly used Chinese recognition materials in post-lingual deafened patients with cochlear implant.
Ye WANG ; Ya SHI ; Ying FU ; Qian WANG ; Yifei FU ; Xin XI
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(4):298-303
OBJECTIVE:
To evaluate and compare outcomes effects of Chinese recognition materials in post-lingually deafened patients with cochlear implant.
METHOD:
Thirty-two post-lingually deafened cochlear implant users participated in the study. Each one of them was given a series of speech recognition tests including the speech recognition score of monosyllable words, spondee words, Chinese BKB sentences and MHINT in quiet, as well as speech recognition threshold of HOPE corpus in babble noise. Speech recognition scores and thresholds were compared among these test materials using histograms , scatter diagrams and statistical methods.
RESULT:
Recognition scores for spondee words, Chinese BKB sentences and MHINT were affected by ceiling effects, with 1,14 and 4 cases scored 100% respectivelty. Meanwhile, 17, 26 and 14 cases scored more than 85% correspondingly. On the other hand, speech recognition scores for monosyllable words in quiet and speech recognition threshold for HOPE corpus in babble noise were not affected.
CONCLUSION
For a considerable part of post-lingually deafened patients using cochlear implant, some Chinese speech recognition materials have demonstrated different degrees of ceiling effects. While speech recognition scores for monosyllable words in quiet and recognition threshold for HOPE corpus in noise can evaluate the performance of speech recognition abilitymore objectively.
Cochlear Implantation
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Cochlear Implants
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Humans
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Language
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Noise
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Speech Perception
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Treatment Outcome
7.The development of vocabulary capability at 2-year follow-up in the prelingual deaf children with cochlear implants.
Ying FU ; Yuan CHEN ; Mengdi HONG ; Aiting CHEN ; Qian WANG ; Xin XI ; Lena WONG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(13):1168-1171
OBJECTIVE:
To investigate the development of early vocabulary capability in the prelingual deaf children after cochlear implantation (CI) , and to study the feasibility of current Chinese assessment procedures about language development for hearing-impaired children.
METHOD:
A total of 56 cases with severe-to-profound prelingual deaf children were participated in this study. The vocabulary development of CI children were evaluated by trained audiologists using the vocabulary assessment tools: Chinese communicative development inventory (CCDI) and mandarin expressive and receptive vocabulary test (MERVT). The questionnaire assessed by parents or guardians answered the questionnaire; vocabulary tests were evaluated by children accompanied with audiologists. Patients were assessed before operation and in 2 years after switch-on.
RESULT:
With the rehabilitation, early post-operative vocabulary development gradually improved. The vocabulary increased with an increase in the duration of CI use, and the receptive vocabulary developed earlier than the expressive ones.
CONCLUSION
After 2 years of CI use, the child partly developed the vocabulary capability. Children's vocabulary test, CCDI and MERVT test, is an important index to evaluate the development of children's language ability after cochlear implantation. Vocabulary test, together with auditory and speech perception assessment procedures, constitute a more complete auditory-speech-language evaluation system for Chinese children after cochlear implants.
Asian Continental Ancestry Group
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Child
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Cochlear Implantation
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Cochlear Implants
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Deafness
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therapy
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Follow-Up Studies
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Humans
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Language
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Language Development
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Language Tests
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Speech
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Vocabulary
8.A new norditerpenoid alkaloid from Aconitum taipaicum.
Yang-qing HE ; Zhan-ying MA ; Qian YANG ; Bing-hua YAO ; Li-ming GAO
Acta Pharmaceutica Sinica 2008;43(9):934-937
To investigate the chemical constituents of the roots of Aconitum taipaicum, silica gel column chromatography was used for the isolation and purification of compounds. A new norditerpenoid alkaloid, isodelelatine (1), along with five known alkaloids, atisine (2), delfissinol (3), liangshanine (4), hypaconitine (5) and delelatine (6) were isolated and identified. The structure of the new compound was elucidated on the basis of spectral data.
Aconitine
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analogs & derivatives
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chemistry
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isolation & purification
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Aconitum
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chemistry
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Alkaloids
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chemistry
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Diterpenes
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chemistry
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Molecular Structure
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Plant Roots
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chemistry
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Plants, Medicinal
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chemistry
9.Content detemination of total tannin in Smilax glabra with reddish brown and off-white colored cross section.
Hua ZHANG ; Li-Sha DONG ; Hu-Biao CHEN ; Xi-Cheng HE ; Xiang-Qian GE ; Xi-Gui ZHANG ; Ying-Ying ZHOU
China Journal of Chinese Materia Medica 2013;38(6):852-855
There are two types of decoction of Smilax glabra due to its reddish brown or off-white colored cross section. These two kinds of decoction were found that they have large difference in anti-inflammatory effects and chemical constituents in the preliminary experiments. Comparing and analyzing the content of total tannin in these two kinds of decoction of S. glabra from 28 areas by UV-Vis spectrophotometry were first used to provide some experimental and theoretical development and utilization of this medicinal resource and quality control. Also, the sample recovery test required in Chinese Pharmacopoeia was improved by adding tannic acid instead of gallic acid to samples.
Geography
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Pigmentation
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Reproducibility of Results
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Smilax
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chemistry
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Tannins
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analysis
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isolation & purification
10.Comparative study of the factors in tuberculosis treatment between immigrant workers and local residents in Shenzhen.
Jin-quan CHENG ; Ying-zhou YANG ; Rui-qian XIE ; Wen-ming ZHONG ; Ai-guo TAN ; Yu-xi LUO ; Zu-xun LU
Chinese Journal of Preventive Medicine 2009;43(2):141-145
OBJECTIVETo study the factors affecting the management and treatment of immigrant workers with tuberculosis, to determine the most effective measures and to provide an academic basis for tuberculosis control and prevention strategies targeting the immigrant population.
METHODSA self-designed questionnaire was administered to 1364 immigrant workers with tuberculosis (study group) and 436 local residents (control group) with tuberculosis.
RESULTSWhether a patient's tuberculosis status was discovered or not was related to the medical facilities initially visited, job mobility, and the individual worker's economic condition. The percentage of cases discovered was relatively low among those who made their first visit to a private clinic (39.0%), and 58.4% (796) of immigrant workers delayed their first consultation mainly due to neglecting symptoms (55.9%, 445), subjective perception of symptoms being not severe enough (19.3%, 154) to visit a physician and the inconvenience of visiting a hospital because of its being far away from home (15.8%, 47). As comparing immigrant workers with local residents, the differences of the delay reason between the two groups were statistically significant (chi(2) = 21.49, P < 0.01). And 39.9% (544) of immigrant workers and 49.1% (214) of local residents had had late confirmation. The differences of the delay reasons between the two groups were insignificant (chi(2) = 7.31, P = 0.293). And 17.6% (240) patients of immigrant workers and 13.1% (57) patients of local residents did not keep to their drug regimens in a timely fashion. The differences of the reasons between the two groups were insignificant (chi(2) = 6.66, P > 0.05). And 77.5% (1057) of immigrant workers and 31.8% (138) of local residents were considered that taking medicine in supervision spot might have impact on their lives and work. The differences of the reasons between the two groups were significant (chi(2) = 9.71, P < 0.05). All 79.2% (1080) of immigrant workers and 63.3% (276) of local residents did not obtain medicine according to prescriptions. The differences of reasons between the two groups were statistically significant (chi(2) = 24.84, P < 0.01). And 51.2% (699) of immigrant workers and 46.1% (201) of the registered population did not follow up with doctors' directions for lab tests. The differences of the reasons between the two groups were insignificant (chi(2) = 3.26, P > 0.05).
CONCLUSIONThe influential factors in tuberculosis management and treatment were complex. Prevention strategies should focus on health education and promotion activities to improve awareness in seeking medical services. Also, developing and standardizing reference mechanisms for patients, and alleviating the economic burden of the workers will be critical to reduce the tuberculosis incidence.
China ; epidemiology ; Factor Analysis, Statistical ; Humans ; Transients and Migrants ; Treatment Outcome ; Tuberculosis, Pulmonary ; epidemiology ; prevention & control ; therapy ; Urban Population