1.Risk Factors and Precaution for Senile Diabetics Complicated with Urinary Tract Infections
Li XU ; Kang JI ; Yiming FAN ; Tao XI
Chinese Journal of Nosocomiology 2009;0(17):-
OBJECTIVE To study risk factors in senile diabetics complicated with urinary tract infections and find out measures to cut down the incidence rate with urinary tract infection.METHODS The age,sex,hospital day,course of diabetes,blood sugar level and catheterization in 181 hospital patients of senile diabetics complicated with urinary tract infections from 2004 to 2007 were analyzed retrospectively.RESULTS The incidence of senile diabetics complicated with urinary tract infections was closely related with age,sex,hospitalization days,course of diabetes,blood sugar level and catheterization.CONCLUSIONS Control measure for risk factors in senile diabetics can actively cut down the incidence rate of urinary tract infection.
2.Effects of Coal Burning Related Endemic Fluorosis on Body Development and Intelligence Levels of Children
shou-ying, WANG ; he-xi, ZHANG ; wei, FAN ; shi-jie, FANG ; pei-ping, KANG ; xin-hua, LI ; xu-guang, CHEN ; mao-juan, YU
Journal of Applied Clinical Pediatrics 2004;0(09):-
Objective To study the effects of coal burning related endemic fluorosis on body development and intelligence levels of fluorosic children in Zhijin county.Methods One hundred and seventy-six fluorosic children and 50 healthy(without fluorostic teeth) children aging 7-12 years who were sampled in cluster sampling were examined for urine fluorosis,physical examination and intelligence tests in Zhijin county,with coal burning pollution related fluorosis.Results Physical development of sick children and the children in control group were in low levels. The intelligence levels and the leves of urine fluorosis in study group were lower than those in control group and there was a significant difference(P
3.The drug-resistant mechanism of clinical non-fermenting bacilli producing IMP-1 metalloenzyme.
Xi CHENG ; Wenxiang JIA ; Baozhong DU ; Wei ZENG ; Mei KANG ; Zairong ZHANG ; Yi XIE ; Weiqing YANG ; Hong FAN ; Chuanmin TAO ; Lei ZHANG
Journal of Biomedical Engineering 2007;24(4):876-879
A total of 50 clinical imipenem-resistant isolates of Pseudomonas aeruginosa and Acinetobacter baumannii were subjected to the ceftazidime-2- mercaptoethanol -double-disk synergy test and to the PCR assays with primers specific for bla(IMP-1). After the process of sequencing the positive one to identify the results, PCR analysis was conducted with primers specific for class 1 integrons. For synergy test, 28 isolates gave positive results, among which were 27 Pseudomonas aeruginosa and Acinetobacter baumannii. Only one Pseudomonas aeruginosa was found to carry bla(IMP-1), and bla(Int1) at the same time. This is the first ascertainment of IMP-1 producing Pseudomonas aeruginosa isolate carrying bla(IntI1) in West China, which is of significance to the research on the clinical spread of these drug-resisitant genes.
Acinetobacter baumannii
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drug effects
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genetics
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Anti-Bacterial Agents
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pharmacology
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Ceftazidime
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pharmacology
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Drug Resistance, Multiple, Bacterial
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genetics
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Fermentation
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Imipenem
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pharmacology
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Mercaptoethanol
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pharmacology
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa
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drug effects
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genetics
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beta-Lactamases
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genetics
4.Exploration of Pharmaceutical Practice for Drug-induced Liver Injury
Lei KANG ; Xiaowei LIN ; Guodong WANG ; Yufei XI ; Jing TANG ; Gaolin LIU ; Guorong FAN
China Pharmacist 2017;20(11):2025-2029
Objective:To explore a new way of pharmaceutical service mode for disease treatment. Methods:Clinical pharmacists actively participated in the pharmaceutical care for a patient with mixed liver injury, and provided clinical pharmaceutical services through the adverse reaction analysis,etiological mechanisms exploration,therapeutic drugs selection and risk factors prevention. Re-sults:Clinical pharmacists cooperating closely with physicians helped to identify problems in time,and then the medication analysis in the fields of drug selection, dose determination, efficacy evaluation and indicators detection was performed, so that the strategies on medicine treatment could be adjusted timely as the disease progressed. With the gradual recovery of liver function, the patient dis-charged after the conditions were improved. Conclusion:By participating in pharmaceutical practice,clinical pharmacists can provide clinical pharmaceutical service,which is helpful to safety improvement and efficiency of drug administration. It is also an effective way to enhance the learning ability of pharmacists,and cultivate their clinical thinking and practice capacity.
5.Risk Factors and Pregnancy Outcomes: Complete versus Incomplete Placenta Previa in Mid-pregnancy
Yun FENG ; Xue-Yin LI ; Juan XIAO ; Wei LI ; Jing LIU ; Xue ZENG ; Xi CHEN ; Kai-Yue CHEN ; Lei FAN ; Qing-Ling KANG ; Su-Hua CHEN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2018;38(4):597-601
This prospective study was conducted to compare risk factors and pregnancy outcomes between women with complete placenta previa and those with incomplete placenta previa diagnosed in mid-pregnancy.The study was carried out from April 2014 to December 2015,during which 70 patients with complete previa and 113 with incomplete previa between 20+0 weeks and 25+6 weeks of gestation were included.Maternal demographics and pregnancy outcomes were compared between the two groups.Comparisons between categorical variables were tested by chi-squared test and those between continuous variables by Student t test.Resolution ofprevia occurred in 87.43% of the studied women.The mean gestational age at resolution was 32.1±4.4 weeks.Incidence of maternal age ≥35 years and incidence of prior uterine operation >3 were high in women with complete previa (28.6%vs.8.8%,P=0.003;28.6% vs.8.8%,P=0.003).Resolution of previa occurred less often in complete previa group (74.3% vs.95.6%,P=0.001).Women with complete previa admitted earlier (37.3±2.0 weeks vs.38.1±1.4 weeks,P=0.011) and delivered earlier (37.7±1.2weeks vs.38.3±1.4 weeks,P=0.025).Maternal age ≥35 years and prior uterine operation >3 increase the risk of complete previa in mid-pregnancy.Placenta previa is more likely to persist in women with complete previa than those with incomplete previa diagnosed in midpregnancy.What is more,women with complete previa in mid-pregnancy deliversearlier.
6. Quantification of left ventricular performance in different phenotypes of hypertrophic cardiomyopathy
Nan KANG ; Jing WANG ; Liwen LIU ; Hong AI ; Fan YANG ; Lei ZUO ; Wenxia LI ; Mengyao ZHOU ; Chuang YE ; Zhiling MA
Chinese Journal of Ultrasonography 2019;28(10):829-836
Objective:
To evaluate the characteristics of left ventricular structure, function, myocardial mechanics, hemodynamics and synchrony in different phenotypes of hypertrophic cardiomyopathy (HCM) using state-of-the-art echocardiography.
Methods:
A consecutive series of 85 adult HCM patients who were admitted to the Xi Jing HCM center from January 2016 to November 2017 were collected. According to the peak left ventricular outflow tract pressure gradient in exercise stress echocardiography, the patients were divided into three groups: patients with non-obstructive HCM (
7.Microsurgical management of meningiomas in the trigone of the lateral ventricle
Yong TANG ; You-Wu FAN ; Han-Dong WANG ; Kang-Jian SUN ; Yun-Xi PAN ; Jie LI ; Zhi-Gang HU ; Meng-Liang ZHOU ; Lei MAO
Journal of Medical Postgraduates 2018;31(1):52-55
Objective Meningiomas in the trigone of the lateral ventricle are characterized by deep location and low inci-dence. A few studies have been done on its treatment at home and abroad. This study was to explore the access,techniques,and clini-cal effect of microsurgery for lateral ventricular trigone meningiomas (LVTM). Methods We retrospectively analyzed the clinical data about 36 cases of LVTM treated by microsurgery in our hospital from December 2011 to December 2015. The operation involved lumbar cistern tube drainage, intraoperative drainage of cerebrospinal fluid, a unilateral parieto-occipital U-shaped cut, approach through the interparietal fissure,a sagittal incision about 3 cm long at the interparietal fissure for exposure and resection of the tumor. We followed up the patients for a mean of 17 months postoperatively and analyzed the results and complications. Results Simpson grade I removal of the tumors was achieved in all the 36 cases. Postoperative complications included homonymous hemianopia in 4 cases, central nervous system infections in 3,secondary epilepsy in 2,subcutaneous hydrops in 2,and intratumoral hemorrhage in 1 (which necessitated a second operation). Extended temporal horn of the right lateral ventricle occurred at 32 months after surgery,which was treated by fistulation. Homonymous hemianopia was improved in 2 of the 4 ca-ses. All the patients were capable of daily life activities and none experienced recurrence. Conclusion Sufficient preoperative evalu-ation of the tumor characteristics,rational selection of surgical approach,and expert operation techniques are the key factors for the mi-crosurgical treatment of meningiomas in the trigone of the lateral ventricle.
8.Incidence of chronic obstructive pulmonary disease and risk factors in the Suzhou cohort.
Meng Shi YANG ; Xi Kang FAN ; Jian SU ; Hao YU ; Yan LU ; Yu Jie HUA ; Pei PEI ; Jun LYU ; Ran TAO ; Jin Yi ZHOU ; Ming WU
Chinese Journal of Epidemiology 2023;44(6):868-876
Objective: To understand the incidence of chronic obstructive pulmonary disease (COPD) in the Suzhou cohort, and explore the risk factors for the development of COPD in Suzhou, and provide a scientific basis for COPD prevention. Methods: This study was based on the China Kadoorie Biobank project in Wuzhong District, Suzhou. After excluding individuals with airflow obstruction and self-reported chronic bronchitis, emphysema, or pulmonary heart disease at baseline, 45 484 individuals were finally included in the analysis. Cox proportional risk models were used to analyze risk factors of COPD and calculate hazard ratios and 95% confidence interval (CI) in the Suzhou cohort. The effect modifications of smoking on the association between other risk factors and COPD were evaluated. Results: Complete follow-up was available through December 31, 2017. Participants were followed up for a median of 11.12 years, and 524 individuals were diagnosed with COPD during the follow-up period; the incidence was 105.54 per 100 000 person-years. Multivariate Cox proportional risk regression models showed that age (HR=3.78, 95%CI:3.32-4.30), former smoking (HR=2.00, 95%CI:1.24-3.22), current smoking (<10 cigarettes/day, HR=2.14, 95%CI:1.36-3.35;≥10 cigarettes/day, HR=2.69, 95%CI:1.60-4.54), history of respiratory disease (HR=2.08, 95%CI:1.33-3.26), daily sleep duration ≥10 hours (HR=1.41, 95%CI:1.02-1.95) were associated with increased risk of COPD. However, education level of primary school and above (primary or junior high school, HR=0.65, 95%CI:0.52-0.81; high school and above, HR=0.54, 95%CI:0.33-0.87), consuming fresh fruit daily (HR=0.59, 95%CI:0.42-0.83) and consuming spicy food weekly (HR=0.71, 95%CI:0.53-0.94) were associated with reduced risk of COPD. Conclusions: The incidence of COPD is low in Suzhou. Older age, smoking, history of respiratory disease, and long sleep duration were risk factors for the development of COPD in the Suzhou cohort.
Humans
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Incidence
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Pulmonary Disease, Chronic Obstructive/epidemiology*
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Risk Factors
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Smoking/epidemiology*
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Tobacco Smoking
9.Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease.
Yida QU ; Pan WANG ; Hongxiang YAO ; Dawei WANG ; Chengyuan SONG ; Hongwei YANG ; Zengqiang ZHANG ; Pindong CHEN ; Xiaopeng KANG ; Kai DU ; Lingzhong FAN ; Bo ZHOU ; Tong HAN ; Chunshui YU ; Xi ZHANG ; Nianming ZUO ; Tianzi JIANG ; Yuying ZHOU ; Bing LIU ; Ying HAN ; Jie LU ; Yong LIU
Neuroscience Bulletin 2023;39(10):1533-1543
Alzheimer's disease (AD) is associated with the impairment of white matter (WM) tracts. The current study aimed to verify the utility of WM as the neuroimaging marker of AD with multisite diffusion tensor imaging datasets [321 patients with AD, 265 patients with mild cognitive impairment (MCI), 279 normal controls (NC)], a unified pipeline, and independent site cross-validation. Automated fiber quantification was used to extract diffusion profiles along tracts. Random-effects meta-analyses showed a reproducible degeneration pattern in which fractional anisotropy significantly decreased in the AD and MCI groups compared with NC. Machine learning models using tract-based features showed good generalizability among independent site cross-validation. The diffusion metrics of the altered regions and the AD probability predicted by the models were highly correlated with cognitive ability in the AD and MCI groups. We highlighted the reproducibility and generalizability of the degeneration pattern of WM tracts in AD.
Humans
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White Matter/diagnostic imaging*
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Diffusion Tensor Imaging/methods*
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Alzheimer Disease/complications*
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Reproducibility of Results
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Cognition
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Cognitive Dysfunction/complications*
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Brain/diagnostic imaging*
10.Prevention and control of HIV/AIDS in China: lessons from the past three decades.
Jun-Jie XU ; Meng-Jie HAN ; Yong-Jun JIANG ; Hai-Bo DING ; Xi LI ; Xiao-Xu HAN ; Fan LV ; Qing-Feng CHEN ; Zi-Ning ZHANG ; Hua-Lu CUI ; Wen-Qing GENG ; Jing ZHANG ; Qi WANG ; Jing KANG ; Xiao-Lin LI ; Hong SUN ; Ya-Jing FU ; Ming-Hui AN ; Qing-Hai HU ; Zhen-Xing CHU ; Ying-Jie LIU ; Hong SHANG
Chinese Medical Journal 2021;134(23):2799-2809
In the past 37 years, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has undergone various major transmission routes in China, with the world most complex co-circulating HIV-1 subtypes, even the prevalence is still low. In response to the first epidemic outbreak of HIV in injecting drug users and the second one by illegal commercial blood collection, China issued the Anti-Drug Law and launched the Blood Donation Act and nationwide nucleic acid testing, which has avoided 98,232 to 211,200 estimated infections and almost ended the blood product-related infection. China has been providing free antiretroviral therapy (ART) since 2003, which covered >80% of the identified patients and achieved a viral suppression rate of 91%. To bend the curve of increasing the disease burden of HIV and finally end the epidemic, China should consider constraining HIV spread through sexual transmission, narrowing the gaps in identifying HIV cases, and the long-term effectiveness and safety of ART in the future.
Acquired Immunodeficiency Syndrome/prevention & control*
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China/epidemiology*
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Disease Outbreaks
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HIV Infections/prevention & control*
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Humans
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Prevalence