1.The observation on the effect of recombinant human interleukin-11 inhalation for preventing and curing radioactive laryngitis
Chinese Journal of Practical Nursing 2014;30(21):6-8
Objective To conduct prospective randomized controlled clinical observation on patients with nasopharyngeal carcinoma under chemotherapy and radiotherapy using inhaling therapy with recombinant human interleukin 11,and the preventing and curing effect of recombinant human interleukin 11 on radiation-induced pharyngitis is evaluated.Methods 161 cases of newly diagnosed patients with head and neck cancer were selected under the principle of informed consent and these 161 cases were divided into the observation group (87 cases) and the control group (74 cases) based on randomization principle.In the observation group,when the dose reached 20Gy,then recombinant human interleukin-11 inhaling therapy was applied `ll the end of radiotherapy,for the control group,conventional treatment was applied in the event of radioactive throat.RTOG criteria were used during the observation in patients with the occurrence and treatment of radioactive pharyngitis.Results When compared with the control group,the average time for radioactivity to appear was prolonged,the severity decreased and the healing time was shortened in the observation group,those data were statistically significant.Conclusions Recombinant human interleukin-11 inhaling therapy can prevent and cure inhalation of radioactive pharyngitis and this therapy is better than conventional treatment.It's worthy of further study and clinical application.
2.Cost-effectiveness Analysis on Five Regimens of Antibacterial Drug Therapy in the Treatment of Community Acquired Pneumonia
China Pharmacy 1991;0(05):-
OBJECTIVE: To evaluate the cost-effectiveness of five regimens of antibacterial drug therapy in the treatment of community acquired pneumonia. METHODS: A retrospective study was conducted, in which a total of 128 cases with pneumonia were enrolled and randomly assigned to receive each of the following 5 therapies,cefoperazone sodium/ sulbactam sodium(Group A),levofloxacin(Group B),amoxicillin/ clavulanate potassium(Group C),azithromycin plus ceftazidime(Group D),and cefoxitin(Group E),the therapeutic effects were monitored and the cost-effectiveness analyses were conducted on the five groups. RESULTS: The costs of the five regimens were 2 137.0 yuan, 1 393.0 yuan, 1 152.5yuan, 2 044.2 yuan and 1 827.0 yuan, respectively;The effective rates were 85.2%, 86.6%, 80.6%, 89.6% and 78.5%, respectively;The cost-effectiveness ratios were 25.08 , 16.09, 14.30, 22.82 and 23.27, respectively; As compared with group C, the incremental cost-effectiveness ratios of the other four groups were 214.02,40.08, 99.08 and —321.19, respectively. CONCLUSION: The therapy of amoxicillin/ potassium clavulanate is superior to the other regimes in the treatment of community acquired pneumonia.
3.Nineteen cases of panic disorder treated with muscular needling tech nique at Neiguan (PC 6).
Chinese Acupuncture & Moxibustion 2014;34(2):155-156
Acupuncture Points
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Acupuncture Therapy
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Adult
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Aged
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Aged, 80 and over
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Female
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Humans
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Male
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Middle Aged
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Panic Disorder
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psychology
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therapy
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Treatment Outcome
4.Discussion on the Ways of Building Harmonious College Libraries
Chinese Journal of Medical Education Research 2002;0(01):-
The article dicusses the status and roles of libraries in building a harmonious socialist society and probes into the main ways of building harmonious college libraries.
5.The level and clinical significance of serum anti-lysosomal associated membrane protein-2 antibody in patients with ANCA-associated glomerulonephritis
Chinese Journal of Nephrology 2014;30(7):494-498
Objective To investigate the relationship of the serum anti-lysosome associated membrane protein 2 (LAMP-2) antibody levels and anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis.Methods Thirty-three patients with new onset ANCA-associated glomerulonephritis and thirty healthy controls were enrolled.ANCA detection was performed using indirect immunofluorescence (IIF).Enzyme-linked immunosorbent assay (ELISA) was used to detect myeloperoxidase (MPO),proteinase-3 (PR3) and other ANCA-associated antibodies including LAMP-2.The cut-off value of the serum anti-LAMP-2 antibody was determined by a receiver operating characteristic (ROC) curve.Results The serum levels of anti-LAMP-2 antibody in new onset ANCA-associated glomerulonephritis patients were significantly higher than remission stage ANCA-associated glomerulonephritis patients and healthy controls (P < 0.05).The serum levels of anti-LAMP-2 antibody showed no visible difference between the remission ANCA-associated glomerulonephritis patients and healthy controls (P > 0.05).The levels of anti-LAMP-2 antibody showed a strong positive correlation with ESR,Scr,BUN,proteinuria,crescent proportion and Birmingham vasculitis activity score (BVAS) and a negative correlation with Ccr,Hb and Alb.Conclusions Anti-LAMP-2 antibody is correlated with the activity of ANCA-associated glomerulonephritis and the severity of renal damage.It may be a useful indicator on the activity of ANCA-associated glomerulonephritis.
6.New methods to detect autophagic flux.
Acta Pharmaceutica Sinica 2016;51(1):45-51
Autophagy is a crucial biological process of eukaryotes, which is involved in cell growth, survival and energy metabolism, while the premise of the autophagy function is activated autophagic flux. It has been confirmed that impaired autophagic flux promotes pathogenesis of many chronic inflammatory diseases, especially cancer, neurodegenerative disease and tissue fibrosis, therefore the analysis of autophagic flux state is important for revealing autophagy function and the mechanism of autophagy related diseases. Given that autophagy is a dynamic process with multiple steps, it is very hard to observe the real state of autophagic flux. Summarized here is the novel concept and current approach to detect autophagic flux. This knowledge is crucial for the researching of the biological function of autophagy, and may provide some strategies for developing autophagy-related drug.
Autophagy
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Fibrosis
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Humans
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Inflammation
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pathology
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Neoplasms
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pathology
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Neurodegenerative Diseases
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pathology
7.Study on sleep disorders in patients with Parkinson' s disease by polysomnogram
Chinese Journal of Neurology 2005;0(07):-
Objective To observe the polysomnographic manifestation of sleep disorder and the characteristics of sleep architecture in patients with PD.Methods 42 patients with PD and 40 normal controls underwent night polysomnography.The parameters of sleep architecture and progress in two groups and video-monitoring features were analyzed.Results According to PSG recordings,the incidence of difficulties in the initiation of sleep(73.8%),fragmented sleep(59.5%),excessive daytime sleepiness (46.1%)were respectively increased in PD patients group than that in controls(all P5)、 ESS were increased(P=0.022,0.000,0.007, 0.001,0.000,respectively).SOREMPs occurred in 6 patients(14.3%)in PD group,but didn't oecure in controls.In PD group REM without atonia(RWA)was demonstrated in 36 patients(85.7%),RBD in 19 patients;in control group,however,REM in 6 and RBD in 2 separately.The statistics analysis showed the incidence of RWA(85.7%)and RBD(45.2%)in PD group was significantly higher than that in control group(P
8.Advances in research on the application of metabonomics in military fitness training monitoring
Xi YANG ; Lichun ZHOU ; Hua HU
Military Medical Sciences 2014;(7):550-553
It is important to meet the need of modern high-technology war during the new period in which our army change the modes of generating combat capabilities .How to more scientifically and effectively improve the soldiers′physical quality and reserve ability will play a key role in soldiers′operations training .Therefore,the metabonomic analysis will pro-vide a new idea for the military physical training monitoring .The application of metabonomics to military fitness training monitoring is described in this paper .
9.Evaluation of Piecewise Direct Standardization Algorithm for Near Infrared Quantitative Model Updating
Chenchen XI ; Yanchun FENG ; Changqin HU
Chinese Journal of Analytical Chemistry 2014;(9):1307-1313
The near infrared ( NIR ) spectra of 76 batches of the amoxicillin capsules from different manufacturers and their corresponding content powder without capsules cell were used to find some quantitative indicators to evaluate whether the piecewise direct standardization ( PDS ) algorithm succeeded in NIR quantitative model updating. 54 batches were used to construct the NIR quantitative model for capsule preparation. All the NIR spectra of amoxicillin capsules were divided into five classes by cluster analysis, and each class can be regarded as a homology sample set. The average spectrum for each homology sample set was calculated. Ten to Fifteen spectra were selected from each homology sample set as the corresponding master spectra of the PDS algorithm to correct all the NIR spectra of the amoxicillin content powder respectively. Then the corrected spectra were predicted by the constructed NIR quantitative model for amoxicillin capsules. The prediction error for each corrected powder spectrum, and the correlation coefficient between each corrected powder spectrum and the average spectrum of the corresponding homolog sample set which the PDS master spectra came from, were calculated. Finally, the relationship between the prediction error and its corresponding correlation coefficient were studied. It was found that the correction results correlated closely with the selected master spectra set in PDS algorithm. The bigger the correlation coefficient ( r) , the better the correction results. In general, when r is less than 99%, it can be judged that the PDS correction is failed. At this condition, the prediction error is often more than 5%. Therefore, the correlation coefficient between the corrected spectrum and its corresponding average spectrum of the homology sample set can be used as an indicator to evaluate the efficiency of the PDS correction.
10.Investigation on prostate cancer associated gene expression pattern
Xiaoqing XI ; Yingbo HU ; Yong WU
Chinese Journal of Urology 2001;0(11):-
Objective To investigate the genes differentially expressed in prostate cancer and to determine some prostate cancer associated genes for diagnosis and treatment prostate cancer. Methods cDNA microarray chips containing 4 366 human genes in full length were used to investigate the differential gene expression patterns of samples from human prostatie cancers and normal prostate tissues. Results A total of 287 genes differentially expressed with prostatie cancers and normal prostate were screened out,comprising 165 unknown genes and 122 known genes.Among the known genes we further identified 56 genes which were markedly differentially expressed (20 up-regulated and 36 down-regulated genes). Conclusions cDNA microarray chips for analysis of genes expression patterns is a powerful method for identification of novel prostatie cancer associated genes.