As the newest anti-vascular endothelial grown factor (VEGF) drug,alfibercept binds to all forms of VEGF-A,VEGF-B, and PIGF.So far, intravitreal injection of alfibercept has already been used to treat certain opthalmological diseases, such as neovascular age-related macular degeneration, polypoidal choroidal vasculopathy, central retinal vascular occlusion, diabetic macular edema, corneal neovascular,and retinopathy of prematurity.In this article,we contrasted alfibercept to the other anti-VEGF drugs, conducted a review of the recent research progress of alfibercept in opthalmological diseases and introduced the questions which still need to be solved and the probably research direction of alfibercept in the future.

The paper summarized the current situation of diagnosis and treatment of pancreatic endocrine tumors (PETs)in China.In recent sixty years, we understand PETs more deeply, and have all kinds of imaging technique to localize the tumors.It makes more cases having been diagnosed.Operation is the most important and the first choice of treatment.The concept of minimal-invasion runs through the surgical procedure.Multi-model strategy is used in therapy for malignant PETs with liver metastasis.Basic research is focused in mechanism and early diagnosis and it helps the clinical practice.Specialization and co-operation are emphasized in the development of PETs diagnosis and treatment.

The theory of'preventing possible disease'in Traditional Chinese Medicine(TCM) is an important content of present theoretical and applied researches in TCM.After learning Daoxue and Chinese medicine,the author believes that ancient people give more attention to vitality than physique.Most of the diseases are caused by the injury of vitality,so the key to 'preventing possible disease'is not only conservation of the physique,but also conservation of the vitality.It is emphasized that the heart can communicate with natural pneuma,and the body can follow the qi transformation of nature when the human body is in the natural state.When one concentrates his spirit internally and keeps a sound mind,the genuine qi will come in the wake of it,and illness can be avoided.Researches on the theory of'preventing possible disease'must not ignore the apprehension and exploration of vitality.

From April 2011 to October 2013,68 patients scheduled for complex hepatobiliary and pancreatic surgery underwent full-thickness suturing of abdominal incision with subcutaneous negative pressure drainage.There was no such complications as wound dehiscence or sinus formation.Except for 2 cases of wound infection,primary healing was achieved.Two infected cases were followed up for 1 year and there was incisional hernia.The full-thickness suturing of abdominal incision plus subcutaneous negative pressure drainage could prevent postoperative wound infection and promote wound healing.And this simple and practical approach is worthy of wider clinical application.

Antiinflammatio No. 6 (AI6) is an effective anti-infective drug composed of four traditional Chinese medicines, namely, Lonicera japonica Thunb, Taraxacum mongolican I-Iand-Mazz, Isatis tinctoria L. and Houttuynia cordata Thunb. It was demonstrated in our experiments that the drug was able to enhance the oxidative burst of rat peritoneal macrophages as shown by increased production of H_2O_2 and exaggerated reduction of nitroblue tetrazolium (NBT). It seems likely that by these means AI6 could promote the bactericidal function of macrophagcs. NBT rcduction of macrophages was examined both by spectrophotometric quantification and electromicroscopic observation.

Adult ; Humans ; Orthodontics, Corrective ; methods ; Periodontium

Purpose To investigate the chest CT features of lung injury caused by oral paraquat,and deepen the understanding of paraquat poisoning.Materials and Methods The chest CT features of 74 patients with lung injury caused by oral paraquat were analyzed retrospectively and comparatively.74 patients were divided into 3 groups according to toxic dose:28 cases in the low dose group (paraquat dose less than 10 ml),34 cases in the medium dose group (paraquat dose among 11 to 50 ml),and 12 cases in the large dose group (paraquat dose more than 50 ml).74 patients were also divided into 3 groups according to course of disease:The course of disease among 1 to 7 days were in the early period,8 to 14 days in the medium period,and 14 days later in the later period.The image features were summarized by comparing the chest CT features,with toxic dose,course of disease,and the scope of lung injury.Results Poisoned patient's chest CT features,related with toxic dose (P＜0.05),appeared from increased bronchovascular shadows,ground glass opacity,to effusion and consolidation,and to pulmonary fibrosis along with time.The effusion and consolidation majorly located in the lateral lungs,which showed a characteristic disease extent.Conclusion The chest CT features of lung injury,caused by oral paraquat,have a certain characteristic.It relates to toxic dose and course of disease,which has a certain guiding significance to clinical diagnosis and treatment.

Since the 1960s,endovascular coil embolization has gradually become another treatment for intracranial aneurysms in addition to craniotomy clipping surgery,and in recent years,it has become the preferred method for many neurologists.However,the complexity of intracranial vascular anatomy and the diversity of intracranial aneurysm make the coil embolization alone unable to meet the needs of all intracranial aneurysms.And then some novel materials and techniques emerged,such as coated coils,balloon-assisted embolization,stent-assisted embolization,and covered stents.The principle of covered stents for the treatment of intracranial aneurysms is to place a kind of stents with bio-physical barriers into the parent arteries,while maintaining the patency of the parent artery,thus isolating aneurysms,leading to thrombogenesis inside and finally curing the lesions while maintaining the patency of parent arteries.It has huge advantage in the treatment of wide-necked,huge,dissecting and pseudo aneurysms without important adjacent branch vessels.This article reviews the application situation and the prospects of development of covered stents in the treatment of intracranial aneurysms.

With the increasing incidence and high malignancy, pancreatic cancer is still expected to be treated by radical resection. However, because of the unique anatomical and biological features, such as rapid progression, early metas-tasis and direct invasion to the vessels, the resection rate of pan-creatic cancer is still at a lower level. The standard procedures of diagnosis and treatment, including early detection, preopera-tive resectability assessment, and judgement of the resection area based on the tumor staging, benefit the patients and significantly improve the prognosis.

Objective: To investigate the histological changes of rapid tooth movement in dogs treated by resistance reduction and distraction osteogenesis, aiming to establish an animal model and further to reveal the remodeling mechanism of rapid tooth movement. Methods: A total of 8 local hybrid dogs were selected as subjects for this study. The second pre-molar was extracted on both sides. The experimental side underwent alvelor surgery for resistance reduction and a home-made tooth-borne intraoral distraction device was installed for rapid tooth movement, while for the other side (control side) only tooth-borne intraoral distraction device was used for rapid tooth movement. The longest active force-delivery span was 2 weeks, followed by 6-week retention. The distance between the moved tooth and anchor unit was recorded weekly, and radiography was performed for each side before and after distraction. The surrounding tissues including periodontal ligament and alveolar bone were sectioned for histological analysis. Results: The average distance of tooth movement was 3.55 mm on the experimental side and 1.11 mm on the control side. The rate of tooth movement was notably higher (P<0.01) and no significant apical root resorption was detected by X-ray on the experimental side. The active alvelor bone remodeling was found on the tension and pressure sides. However, there was no significant difference between the experimental side and the control side after the retention period. Conclusion: The rate of orthodontic tooth movement can be accelerated through resistance reduction and periodontal distraction without any unfavorable effects but at minimal anchorage loss.