1.Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs.
Qi MA ; Li WANG ; Hua YAO ; Jun ZHU ; Shuxia WANG ; Xhaoxia ZHANG ; Tingting WANG ; Yan MA ; Yinxia SU ; Zhiqiang WANG ; Lili DING
Chinese Journal of Medical Genetics 2016;33(4):540-544
OBJECTIVETo assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China.
METHODSOne thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system.
RESULTSThe distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups (P>0.05). After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model (OR=1.181, 95%CI: 1.021-1.366, P=0.025; OR=1.296, 95%CI: 1.043-1.610, P=0.019). The total cholesterol level was higher in AA carriers than GG and GA carriers (P<0.05).
CONCLUSIONThe AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.
Adaptor Proteins, Signal Transducing ; genetics ; China ; ethnology ; Cholesterol ; blood ; Diabetes Mellitus, Type 2 ; blood ; etiology ; genetics ; Genotype ; Humans ; Logistic Models ; Polymorphism, Genetic
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