Objective: To explore the effect of voluntary teaching for medical students on cardio-pulmonary resuscitation training for middle school students,and to provide a reference for education of first aid among primary and middle school students. Methods: A total of 196 students from four classes in the first grade of a middle school were selected by convenient sampling method and divided into experimental group and control group according to the class. After the two groups of students were trained in unified theory, the students in the control group were trained by the medical staff in the hospital, and the students in the experimental group were trained by the volunteers of the medical students who had been strictly trained and assessed. After the training was finished, questionnaires were sent out to investigate the effect of training. Results: Before the training, there was no significant difference in the theoretical scores between the two groups (t=1.18，P=0.24). After training, the theoretical and skill scores of the experimental group were(11.43±1.53)(5.68±1.80), that of the control group were(11.35±1.77)(5.30±1.76), and there was no significant difference between the experimental group and the control group(t=0.34，1.48，P>0.05). Conclusion The application of voluntary teaching in the training of middle school students’ cardiopulmonary resuscitation can improve the popularization rate of cardiopulmonary resuscitation, save medical resources effectively, and improve the practical ability of medical students.