1. Size exclusionchromatography-high-performance liquid chromatography-inductively coupled plasma mass spectrometry for measuring the stability of cadmium telluridequantum dots
Huiling LI ; Yue HU ; Peijun MENG ; Xueying ZHANG ; Yunyi XIE ; Peili HUANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2017;35(3):217-220
Objective:
To investigate the peak time and peak area of elements in cadmium telluride quantum dots (CdTe QDs) using size exclusion chromatography-high-performance liquid chromatography-inductively coupled plasma mass spectrometry, as well as the biological stability of CdTe QDs
2. Oxidative damage effects induced by CdTe quantum dots in mice
Guangyun XIE ; Wei CHEN ; Quankai WANG ; Xiurong CHENG ; Jianning XU ; Peili HUANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2017;35(7):487-490
Objective:
To investigate Oxidative damage effects induced by CdTe Quantum Dots (QDs) in mice.
Methods:
40 ICR mice were randomly divided into 5 groups: one control group (normal saline) ; four CdTe QDs (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 0、0.5、5.0、50.0 and 500.0 nmol/ml respectively) . After 24 h, the mice were decapitated and the blood was collected for serum biochemically indexes、hematology indexes, the activities of SOD、GSH-Px and the concentration of MDA were all detected.
Results:
The results showed in the four CdTe QDs exposure groups, the level of CRE、PLT and the concentration of MDA were all significantly lower than those of the control group (
3.High sustained virological response to optimized therapy for refractory chronic hepatitis C treatment-na(i)ve patients: a multicenter randomized study.
Xinyue CHEN ; Jia SHANG ; Ruifeng YANG ; Qing XIE ; Zhiliang GAO ; Xiaoyuan XU ; Xiaoguang DOU ; Guozhong GONG ; Guofeng CHEN ; Jun LI ; Hong CHEN ; Dazhi ZHANG ; Yinong FENG ; Junqi NIU ; Jinlin HOU ; Hong YOU ; Yun WU ; Peili ZHAO ; Huiying RAO ; Lai WEI
Chinese Journal of Hepatology 2015;23(6):412-417
OBJECTIVETo perform a prospective,multicenter,open,randomized study to determine a treatment regimen for treatment-naive patients with refractory chronic hepatitis C (RHC) using the predictive value (PV) of early virological response (EVR).
METHODSA total of 438 patients from 18 hospitals were recruited between December 2008 and December 2010 and administered peg-interferon/ribavirin treatment for 12 weeks. Patients who achieved complete EVR (cEVR) were assigned to group A for a 48-week course of treatment, while patients without cEVR were randomly allocated to either group B 1 for a 72-week course of treatment or to group B2 for a 96-week course of treatment. Serum hepatitis C virus RNA levels at baseline,treatment weeks 4, 12 and 24, end of treatment, and post-treatment week 24 were measured and used to evaluate the efficiency of therapy.
RESULTSThe overall sustained virological response (SVR) rate was 85.1%. In all, 91.0% of patients achieved cEVR and were assigned to group A, which had an SVR rate of 90.8%. There was no statistically significant difference in the SVR rates of groups B1 and B2 (29.4% vs. 25.0%, P more than 0.05). The positive PV of rapid virological response (RVR), cEVR and delayed virological response (DVR) for SVR was 93.4%, 90.8% and 77.8% respectively, and the negative PV of RVR, EVR and DVR for SVR was 28.0%, 93.3% and 100% respectively. Overall, 66.9% of the patients experienced adverse events (AEs), but only 1.9% of patients experienced sevcre AEs.
CONCLUSIONThe majority of Chinese RHC treatmentna(i)ve patients (91.0%) can achieve cEVR and a high SVR rate with a low rate of severe AEs using the cEVR guided personal treatment regimen.
Antiviral Agents ; Asian Continental Ancestry Group ; Drug Therapy, Combination ; Hepatitis C, Chronic ; Humans ; Ribavirin
4.Improved left ventricular endocardial border echo resolution by perfluoropropane-albumin microsphere injection: a multiple center stage Ⅲ clinical study
Xinfang WANG ; Peili GONG ; Mingxing XIE ; Zhaohui WANG ; Yale HE ; Hongwen FEI ; Yuan LIU ; Liang CUI ; Yafeng WU ; Lin XU ; Xianhong SHU ; Cuizhen PAN ; Shizhen LIU ; Guang ZHI ; Xiaoxia WU ; Haiyan NIU ; Yun ZHANG ; Mei ZHANG ; Guihua YAO ; Yanbin SI ; Xiaoyu XIA
Chinese Journal of Ultrasonography 1993;0(04):-
0.05 ). After once injection both observers considered the number of clearly recognized endocardial border segments increased significantly. The number evaluated by observers A increased from 2.68 ? 0.95 to 5.99 ? 0.10 while from 2.82 ? 1.03 to 5.99 ? 0.11 by observers B( P 0.05 ). The average contrast enhancement rate of LV endocardial border was 99.7 %. Perfluoropropane-albumin microsphere injection had no significant effection on vital signs such as blood prssure, heart rate and respiration. Electrocardiogram didn′t change markedly and the variance of the laboratory findings like blood and urine routine examination, hepatic and renal function was in normal range. Only one case( 0.33 %) had slight side-effects who suffered from mild nausea and diarrhea, which suggested the clinical safety of this contrast agent. Conclusions Perfluoropropane-albumin microsphere injection could enhance the resolution of LV endocardial borders and make the judgement of regional myocardial movement easier. It has little side-effects and will be appropriate for clinical use.
5.Bidirectional casual effects between periodontitis and Sjögren's syndrome: a Mendelian randomization study
XIE Peili ; GUO Chenmiao ; YU Ting
Journal of Prevention and Treatment for Stomatological Diseases 2024;32(3):209-215
Objective:
To evaluate the bidirectional association between periodontitis and Sjögren's syndrome using the Mendelian randomization (MR) method.
Methods:
Genome-wide association study (GWAS) data of periodontitis (N = 45 563) and Sjögren's syndrome (N = 214 435) were selected to meet the requirements of the same ethnicity and different regions. Inverse variance-weighted (IVW), MR-Egger, and weighted median (WM) tests were used to evaluate the causal effect. Cochran's Q statistics, MR-Egger intercept, MR-PRESSO and leave-one-out analysis were used as sensitivity analyses to assess the stability and reliability of the results.
Results:
After screening, the GWAS data of Sjögren's syndrome were based on the Finnish region, and the periodontitis GWAS data were based on the UK region, both of which originated from European ancestry. Using IVW (OR = 1.017, 95% CI = 0.956-1.082), MR-Egger (OR = 0.985, 95% CI= 0.956-1.082), and WM (OR =1.021, 95% CI = 0.948-1.099), no causal effect of Sjögren's syndrome on periodontitis was found using any of the three methods. Conversely, no causal effect of periodontitis on Sjögren's syndrome was found (IVW, OR = 1.024, 95% CI = 0.852-1.230; MR-Egger, OR = 0.978, 95% CI = 0.789-1.212; WM, OR = 1.024, 95% CI = 0.846-1.260). The sensitivity analyses indicated that the results were stable and reliable. Cochran's Q test and MR-PRESSO revealed that there was no significant heterogeneity among the instrumental variables, which included single nucleotide polymorphisms (SNPs). The intercept of MR-Egger regression indicated no pleiotropy in the included SNPs. No individual SNP was found that significantly affected the results using the leave-one-out method.
Conclusion
This study does not support a bidirectional causal effect between periodontitis and Sjögren's syndrome.