Cytokine induced killer (CIK)cells are immune effector cells generated from mononuclear cells induced by many cytokines.CIK cells have several advantages, such as rapid proliferation, broad spectrum killing activity, high tumoricidal activity and non-major histocompatibility complex restriction.Recently, cord blood derived CIK cells have attracted extensive concerns because of its faster proliferation, higher tumoricidal activity and lower incidence of GVHD compared with adult peripheral blood derived CIK cells. This paper will review the biological characteristics, clinical application and research advances of cord blood derived CIK cells.

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

AIM: To investigate law of vacuum drying process and provide basic technical supports for drying process and design of drying machine. METHODS: A batch-drying experiment system was used to continuously record the mass and temperature of the drying sample,then the key effective factors and characteristics of different phase of drying process were obtained based on the analysis of the recorded experimental data. RESULTS: The influence of process parameters on evaporation rate varied in different period of drying process. CONCLUSION: In order to improve the efficiency of the integrated drying process,it's necessary to apply appropriate technical methods according to the characteristics of the process.

Objective To assess the performance of onboard oxygen generating and supplying system. Methods A model of a person and 8 volunteers in hypobaric chamber and rapid decompression chamber underwent the tests of producing oxygen ability of the oxygen concentrator of board oxygen generating system normal performance tests on oxygen supply at 0～8 000m, performance tests at cruising altitude for longrange, warning performance tests, secondary oxygen switch tests, positive pressure oxygen performance tests and rapid decompression performance tests. Results All the ability of producing and supply of oxygen, and the normal and the emergency performance of onboard oxygen generating system could fulfill the system physiological requirements. Conclusion On board oxygen generating and supplying system could meet pilots normal and emergeney needs when pilots aviate for long range in high altitude.

AIM: To investigate the effectiveness of dosing technology and excipient application on solid drug's moisture-proof property and to provide a method improving the solid drug's moisture-proof property. METHODS: Based on the analysis of the moisture absorbing process and the absorbing mechanics,a new concept "active moisture absorbance site"(AMAS) was defined and mathematic model was constituted.Two constants as: initial AMAS concentration C_0,moisture resistance coemcient K,were proposed to indicate the drugs moisture-proof ability. The CI WU JIA extracts and SHUANG HUANG LIAN extracts were used to conduct experiments, which were designed to investigate the improvement of the drug's moisture resistance ability when varying the AMAS's concentration and/or its space distribution. RESULTS: Reducing the amount of moisture absorbance excipients in each dosage of solid drug can lower the drug's moisture absorbance ability,and applying a thin film coating material outside the drug can also slow the drug's moisture absorbance rate. CONCLUSION: The proposed mathematic model is useful for finding a way to improve the drug's moisture resistance;experimental data shows that the drug's moisture-proof property would be improved by reducing the amount of moisture absorbance excipient in each dosage and improving the moisture distribution resistance through a certain dosing technology,such as film coating technology.

Adolescent ; Adult ; Aged ; Alleles ; Child ; Female ; HLA-DR Serological Subtypes ; genetics ; Humans ; Male ; Middle Aged ; Myelodysplastic Syndromes ; diagnosis ; genetics ; pathology ; Prognosis ; Young Adult

Objective To summarize the related factors and nursing countermeasures of complications after the laparoscopy-assisted surgery for congenital hypertrophic pyloric stenosis.Methods Clinical data about the occurrence of complications and nursing points were retrospectively analyzed in 106 cases of neonates and infants.Results Surgical complications occurred in 16 cases,including mucosal perforation in 2 cases,abdominal cavity hemorrhage in 1 case,puncture hole infection in 1 case,repeated postoperative vomiting caused by incomplete pyloric separation in 1 case,postoperative hypercapnia in 2 cases,subcutaneous emphysema in 1 case,8 cases of postoperative hypothermia.No operative deaths.No poking holes hernia and abdominal organ injury.By careful observation and nursing,all cases got rid of postoperative complucations.Within postoperative 3～7 days,they were recovered and discharged,no nursing complications occurred.Conclusions Early discovery of complications and timely nursing intervention are important guarantee for patients to pass through laparoscopic surgery smoothly and obtain swift recovery.

Objective To discuss Buyang-huanwu decoction preventing the formation of lower limb deep vein thrombosis (DVT) after major orthopedic surgery.Methods 60 patients were randomly divided into a treatment group and a control group.The treatment group was treated with oral liquid of Buyang-huanwu,twice a day; while the control group was treated with 5000IU of low molecular heparin through subcutaneous injection,once daily.Prothrombin time (PT),activated partial thromboplatin time (APTT),fibrinogen (FIB),D-dimer,lower limb deep vein color B ultrasonic and the wound flow changes after 48 hours were observed at 1st,7th,and 14th day after medication.Results ①)Comparison on the incidence of DVT:The incidence of DVT in the treatment group was higher than the control group at 7th day after medication,this incidence turn to equal in the two groups at the 14th day after medication,while at the end of therapy,the incidence of DVT in the treatment group was lower than the control group with significant difference (P＜0.05).②Comparison on D-dimer changes:D-dimer at the 1st and 14th day were (0.782 ± 0.472) mg/1 and (0.320 ± 0.102) mg/1 in the treatment group and (0.720±0.421)mg/1 and (0.417 ± 0.217) mg/l in the control group.Comparing with the same group before treatment [the treatment group was(0.548±0.245)mg/1; the control group was (0.560±0.195) mg/l],D-dimer was increased at the 1 st day with obvious difference (P＜ 0.05),but reduced at the 14th day,without statistical difference (P＞0.05).Conclusion Buyang-huanwu decoction did not show good effects as low molecular heparin at the beginning of the treatment,but the its whole therapeutic effects and safety was better in treating lower limb deep vein thrombosis after major orthopedic surgery.

Objective: To study the isolation, identification, and biological characteristics of the secondary metabolites of myxobacteria. Methods: A growth inhibition model of Pyricularia oryzae was used to screen the active microbes. The compounds extracted with methanol from the fermentation broth of Myxococcus xanthus 095B06 were separated by silica chromatography, gel filtration chromatography, and high-performance liquid chromatography. The chemical structures of the compounds were identified by 1HNMR, 13CNMR, ESI-MS, and EI-MS techniques. The bioactive activities of the separated compounds were evaluated by Kirby-Bauer Disc Diffusion method and MTT method. Results: Six compounds, namely, Avermectin Ala, Avermectin A2a, Avermectin Bla, Avermectin B2a, ergosta-7,22-dien-3,5,6-triol, and 4-quinolinecarboxylic acid, were obtained. Conclusion: Compound 1, 2, 3, 4, and 5 have been isolated from myxobacteria for the first time and compound 2 and 4 can strongly inhibit the growth of SMMC-7721 cell line, with both IC50 values being 5 g/ml.