1.National experts consensus on clinical diagnosis and treatment of inhalation injury (2018 version).
Burn and Trauma Branch of Chinese Geriatrics Society ; F GUO ; Y S ZHU ; J HUANG ; Y H WU ; Z F SUN ; X B XIA ; Xiaobing FU
Chinese Journal of Burns 2018;34(11):770-775
Inhalation injury is caused by inhalation of heat, toxic or irritating gases which lead to respiratory and pulmonary parenchyma damage. At present, the clinical understanding about it is still limited and lack of effective diagnosis and treatment standard. Based on the experience of diagnosis and treatment of domestic inhalation injury, combined with reports of international researches, criteria (expert consensus) for inhalation injury were systematically discussed from pathological and pathophysiological changes, clinical diagnosis and evaluation, and clinical treatment, which provides reference for clinical diagnosis and treatment of patients inflicted with inhalation injury.
Burns, Inhalation
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Consensus
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Humans
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Lung
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Smoke Inhalation Injury
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diagnosis
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therapy
2.National experts consensus on clinical diagnosis and treatment of inhalation injury (2018 version).
Burn and Trauma Branch of Chinese Geriatrics Society ; F GUO ; Y S ZHU ; J HUANG ; Y H WU ; Z F SUN ; X B XIA ; X B FU
Chinese Journal of Burns 2018;34(11):E004-E004
Inhalation injury is caused by inhalation of heat, toxic or irritating gases which lead to respiratory and pulmonary parenchyma damage. At present, the clinical understanding about it is still limited and lack of effective diagnosis and treatment standard. Based on the experience of diagnosis and treatment of domestic inhalation injury, combined with reports of international researches, criteria (expert consensus) for inhalation injury were systematically discussed from pathological and pathophysiological changes, clinical diagnosis and evaluation, and clinical treatment, which provides reference for clinical diagnosis and treatment of patients inflicted with inhalation injury.
Burns, Inhalation
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Consensus
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Humans
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Lung
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Practice Guidelines as Topic
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Smoke Inhalation Injury
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diagnosis
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therapy
3.Relationship between the HBsAg-positive infection status of mothers and the non/low-response to hepatitis B vaccine of their infants.
Z Q YANG ; H Y HAO ; X H SHI ; Z D FU ; F ZHANG ; X F WANG ; X X XU ; B WANG ; H X WEN ; S Y FENG ; B WANG ; S P WANG
Chinese Journal of Epidemiology 2018;39(6):805-809
<b>Objective:b> To explore the relationship between the status of HBsAg-positive infection of mothers and the non/low-response to hepatitis B vaccine of their infants. <b>Methods:b> A total of 225 pairs of mothers and their infants were recruited in our cohort from June 2011 to July 2013. Infants were given three doses of hepatitis B vaccine at hour 24, first month and month 6(t)h respectively and were followed up for one year after birth. HBV serological markers and HBV DNA in the peripheral blood of both mothers and infants were detected by Electro-chemiluminescence immunoassay and fluorescence quantitative Polymerase Chain Reaction. <b>Results:b> Six HBV infection models were detected in HBsAg-positive mothers, and "HBsAg (+), HBeAg (+), anti-HBc (+)" (model one) and "HBsAg (+), anti-HBe (+), anti-HBc (+)" (model two) accounted for 92.5%(208/225) of all the models. Rate of non/low-response to hepatitis B vaccine in infants born to mothers in model one was lower than those in model two, the differences are statistically significant (χ(2)=4.80, P=0.029). The rate of non/low-response to hepatitis B vaccine in infants showed a downward trend with the rising of HBeAg level in their mothers (χ(2)=4.86, P=0.028). Results from the unconditional logistic regression analysis showed that the HBeAg of the HBsAg-positive mothers was significantly correlated with the low risk of non/low-response to hepatitis B vaccine in infants (OR=0.598, 95%CI: 0.378-0.947). The positive rate of serum HBV DNA in HBsAg-positive mothers was 54.2%, while the rate of non/low-response to hepatitis B vaccine in infants born to HBV DNA positive mothers was similar to those infants born to HBV DNA negative mothers (χ(2)=0.22, P=0.640). <b>Conclusions:b> "HBsAg (+), HBeAg (+), anti-HBc (+)" and "HBsAg (+), anti-HBe(+), anti-HBc (+)" were the common models seen in HBsAg-positive mothers, and the rate of non/low-response to hepatitis B vaccine was different between the two models. HBeAg of HBsAg-positive mothers might have positive effects on the immune response to hepatitis B vaccine in infants but the mechanisms remained not clear. HBV DNA of the HBsAg-positive mothers did not seem to be correlated with the immune response to hepatitis B vaccine in infants.
Adult
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Biomarkers/blood*
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DNA, Viral/blood*
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Diagnostic Tests, Routine
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Female
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Hepatitis B/prevention & control*
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Hepatitis B Antibodies/blood*
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Hepatitis B Surface Antigens/blood*
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Hepatitis B Vaccines/pharmacology*
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Hepatitis B e Antigens/blood*
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Hepatitis B virus/isolation & purification*
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Humans
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Infant
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Infectious Disease Transmission, Vertical/prevention & control*
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Mothers
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Pregnancy
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Pregnancy Complications, Infectious/virology*
4.Dynamic variations of BMI and influencing factors among HIV/AIDS patients receiving highly active antiretroviral therapy in Liuzhou, Guangxi Zhuang Autonomous Region, 2013-2014.
H H CHEN ; B T FU ; Q Y ZHU ; H X LU ; L H LUO ; L CHEN ; X H LIU ; X J ZHOU ; J H HUANG ; X X FENG ; G S SHAN ; Z Y SHEN
Chinese Journal of Epidemiology 2018;39(4):487-490
<b>Objective:b> To understand the dynamic variation of BMI and influencing factors among HIV/AIDS patients receiving highly active anti-retroviral therapy (HAART) in Liuzhou, Guangxi Zhuang Autonomous Region (Guangxi). <b>Methods:b> HIV/AIDS patients receiving HAART for the first time since 1 January 2013 were selected. Data on BMI was analyzed among patients receiving HAART at baseline,6 months and 12 months after treatment. By using the general linear model repeated measures of analysis of variance, BMI dynamic variations and influencing factors were described and analyzed. <b>Results:b> The average BMI of 2 871 patients at baseline, 6th months and 12th months appeared as (20.65±3.32), (20.87±3.22) and (21.18±3.20), respectively, with differences all statistically significant (F=18.86, P<0.001). BMI were increasing over time with treatments (F=37.25, P<0.001). Main influencing factors were noticed as: age, sex, marital status, baseline data of CD(4)(+)T cells and the WHO classification on clinical stages. <b>Conclusions:b> Higher proportion of BMI malnutrition counts was seen among patients before receiving HAART in Liuzhou. BMI of the patients that were on HAART seemed being influenced by many factors. It is necessary to select appropriate treatment protocols on different patients so as to improve the nutritional status of the patients.
Acquired Immunodeficiency Syndrome
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Antiretroviral Therapy, Highly Active
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Body Mass Index
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CD4 Lymphocyte Count
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China/epidemiology*
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HIV Infections/drug therapy*
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Humans
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Linear Models
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Marital Status
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Nutritional Status
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T-Lymphocytes
5.Glomuvenous malformation: a clinicopathological analysis of 31 cases.
Q Y LIU ; W J BAO ; C X LI ; S XUE ; Y Z DING ; D K LIU ; B X MA ; F F FU ; L F KONG
Chinese Journal of Pathology 2023;52(10):1001-1005
<b>Objective:b> To investigate the clinicopathological features of glomuvenous malformation (GVM). <b>Methods:b> Thirty-one cases of GVM diagnosed at the Henan Provincial People's Hospital from January 2011 to December 2021 were collected. Their clinical and pathological features were analyzed. The expression of relevant markers was examined using immunohistochemistry. The patients were also followed up. <b>Results:b> There were 16 males and 15 females in this study, with an average age of 11 years (range, 1-52 years). The locations of the disease included 13 cases in the limbs (8 cases in the upper limbs, 5 cases in the lower limbs), 9 cases in the trunks, and 9 cases in the foot (toes or subungual area). Twenty-seven of the cases were solitary and 4 were multifocal. The lesions were characterized by blue-purple papules or plaques on the skin surface, which grew slowly. The lumps became larger and appeared to be conspicuous. Microscopically, GVM mainly involved the dermis and subcutaneous tissue, with an overall ill-defined border. There were scattered or clustered irregular dilated vein-like lumens, with thin walls and various sizes. A single or multiple layers of relatively uniform cubic/glomus cells were present at the abnormal wall, with scattered small nests of the glomus cells. The endothelial cells in the wall of abnormal lumen were flat or absent. Immunohistochemistry showed that glomus cells strongly expressed SMA, h-caldesmon, and collagen IV. Malformed vascular endothelial cells expressed CD31, CD34 and ERG. No postoperative recurrence was found in the 12 cases. <b>Conclusions:b> GVM is an uncommon type of simple venous malformation in the superficial soft tissue and different from the classical glomus tumor. Morphologically, one or more layers of glomus cells grow around the dilated venous malformation-like lumen, which can be combined with common venous malformations.
Male
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Female
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Humans
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Child
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Glomus Tumor/surgery*
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Endothelial Cells/pathology*
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Paraganglioma, Extra-Adrenal/pathology*
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Immunohistochemistry
6.Economic burden of hepatitis C patients and related influencing factors in Guangdong province.
Q M WU ; Y LI ; X B FU ; F YANG ; J LI ; H Z HUANG ; J YAN ; P LIN
Chinese Journal of Epidemiology 2018;39(7):931-936
<b>Objective:b> To investigate the economic burden of hepatitis C patients and related factors in Guangdong province. <b>Methods:b> In this study, cluster sampling method was used to select cases, including acute hepatitis C, chronic hepatitis C and liver cirrhosis cases from eligible outpatients and inpatients in 1 or 2 large general hospitals in all the 21 cities in Guangdong province. Questionnaire survey was conducted for all the hepatitis C patients to analyze their economic burden, while multivariate linear regression model was used to identify the related influencing factors. <b>Results:b> A total of 356 hepatitis C patients were enrolled in the study, with 176 outpatients (49.4%) and 180 inpatients (50.6%) respectively. The average age of the study subjects was (44.79±11.73) year-olds. The annual direct economic costs of patients with acute hepatitis C, chronic hepatitis C and liver cirrhosis were 10 703.22 (IQR: 7 396.75-16 891.91), 14 886.63 (IQR: 7 274.00-30 228.25) and 28 874.00 (IQR: 13 093.69-56 350.00) Yuan (RMB) respectively. The annual indirect costs appeared as 2 426.99 (IQR: 1 912.18-7 354.52), 3 235.99 (IQR: 1 323.81-6 619.07) and 5 442.35 (IQR: 3 235.99-10 296.33) Yuan (RMB) respectively. The annual intangible costs were 5 000.00 (IQR:2 000.00-10 000.00), 10 000.00 (IQR: 4 000.00-30 000.00) and 10 000.00 (IQR: 3 000.00-100 000.00) Yuan (RMB) respectively. The annual total costs were 22 306.17 (IQR: 14 581.24-50 569.17), 38 050.33 (IQR: 17 449.57-68 319.62) and 80 152.18 (IQR: 40 856.09-228 460.79) Yuan (RMB) respectively. Results from the multiple linear regression analysis showed that factors as: annual hospitalization days, annual number of outpatient visits, annual number of hospitalization, type of disease and the levels of the hospitals were related to the economic burden of patients with hepatitis C. <b>Conclusion:b> Patients with HCV-related diseases presented serious economic problem which calls for close attention in Guangdong province.
Adult
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China/epidemiology*
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Cities
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Cost of Illness
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Female
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Health Care Costs/statistics & numerical data*
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Hepatitis B/epidemiology*
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Hepatitis C/economics*
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Hospitalization
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Humans
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Liver Cirrhosis/epidemiology*
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Male
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Surveys and Questionnaires
7.Mosquitoes, midges and related arboviruses in southeast Sichuan province.
S SONG ; S H FU ; X X ZHOU ; J K ZHANG ; W LI ; L J LIU ; J S LI ; J WANG ; Y LIN ; X L LI ; Y HE ; W W LEI ; H Y WANG ; B WANG ; X Q LU ; G D LIANG
Chinese Journal of Epidemiology 2018;39(10):1381-1386
<b>Objective:b> To investigate the distribution patterns of mosquitoes, midges and related arboviruses in Sichuan province. <b>Methods:b> Blood-sucking insects were collected from houses and pens, using the ultraviolet lights. Mosquito samples were classified according to morphologic characteristics and then stored at liquid nitrogen. All samples were incubated with BHK-21 and C6/36 cells for virus isolation and then detected for their viral genes. Sequences of the virus were identified and analyzed by molecular biological software, such as BioEdit 7.0.5.3, MEGA 6.0. <b>Results:b> In total, 17 019 mosquitoes from 3 genera and 4 species and 12 700 midges were collected from the southeast regions of Sichuan province in 2016 and 2017. Among them, 79.4% (13 519/17 019) belonged to Culex tritaeniorhynchus with 11.1% (1 897/17 019) as Armigeres subalbatus, 5.5% (930/17 019) were Anopheles sinensis and 4.0% (673/17 019) were Anopheles sinensis 3 virus strains that isolated from Culex tritaeniorhynchus were identified as typeⅠ Japanese encephalitis virus. Seven pools of mosquitoes isolated from Hejiang county were identified Japanese encephalitis virus gene positive through PCR amplification. With 4 pool midges were detected positive for Akabane virus through PCR gene amplification while midges samples didn't have virus isolates. <b>Conclusions:b> Culex tritaeniorhynchus appeared the predominant species in the southeast regions of Sichuan. Japanese encephalitis virus transmitted by mosquitoes and Akabane virus by midges were prevalent in southeast Sichuan province.
Animals
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Arboviruses
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Culicidae
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Encephalitis Virus, Japanese/isolation & purification*
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Encephalitis, Japanese/diagnosis*
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Genes, Viral
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Nucleic Acid Amplification Techniques
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Phylogeny
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Polymerase Chain Reaction
8.Knowledge, related behavior and on AIDS/HIV infection among rural adults with Derung minority, in Yunnan province, 2016.
Y N CAI ; Y L MA ; H B LUO ; M Y XIAO ; J NIU ; L J SONG ; X H LI ; L R FU ; Z Y ZHANG ; Q H DAI ; Y L ZHANG ; M H JIA
Chinese Journal of Epidemiology 2018;39(4):483-486
<b>Objective:b> To understand the related risk behaviors, knowledge and status of HIV/AIDS infection among rural adults of Derung minority, to provide relevant messages for the development of HIV/AIDS intervention strategy in this minority group. <b>Methods:b> We used system sampling method to conduct a cross-sectional survey in 6 administration villages of Derung Township, Gongshan Derung and Nu Autonomous County in Nujiang Lisu Autonomous Prefecture of Yunnan Province, with a sample size estimated as 383. Adult residents with Derung minority in six villages of Gongshan County were involved, with relevant information collected through door-to-door visit. HIV antibody was tested and SPSS 17.0 was used for statistical analysis. <b>Results:b> Information on 394 valid respondents was collected, with age as between 18 and 65 (34.39±9.74), 80.7% (318/394) as married, 54.0% (213/394) having had primary school education, 13.2% (52/394) as migrant workers. In this population, the overall HIV infection rate appeared as 0.5% (2/400), mainly through sexually transmission. The rate of awareness on HIV/AIDS was 69.8% (275/394), mainly through free publicized materials 50.0% (197/394). Rates on premarital sexual behavior on multiple sexual partners in the past year, on temporary sexual partners in the past year, having commercial sexual experiences in the past year and ever used condoms when engaging in casual sex, were 6.4% (60/366), 18.0%(66/366), 5.7%(21/366), 1.9%(7/366) and 8.0%(25/311), respectively. <b>Conclusions:b> Few numbers of HIV infections were identified among the migrating workers with Derung minority, with sexual transmission as the major route, along with the increased number of rural migrant workers and the low rates both on AIDS knowledge and condom use, accompanied by the high risk sexual behavior appeared in this rural adult residents of Derung minority. Relative strategies on HIV/AIDS intervention and control should be developed.
Acquired Immunodeficiency Syndrome
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Adult
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China/epidemiology*
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Condoms
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Cross-Sectional Studies
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HIV Infections/epidemiology*
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Health Knowledge, Attitudes, Practice
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Humans
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Infections
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Risk-Taking
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Rural Population/statistics & numerical data*
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Sexual Behavior
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Sexual Partners
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Surveys and Questionnaires
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Transients and Migrants