Objective To investigate the effects of psychological intervention on relieving the emotional state and improving life quality for patients with leukemia during clinical nursing.Methods A total of 120 cases of leukemia were collected to follow up one year,and were divided into routine treatment group (60 cases) and psychological intervention group (60 cases) respectively.The emotional states of both groups were compared using hospital anxiety and depression scale (HADS),while the life quality of patients was assessed andcompared by quality of life questionnaire (EORTC-QLQ).Results Mter one year of follow-up,the mean HADS score of routine treatment group was (8.3 ± 3.2),whereas that of psychological intervention group was (6.2 ± 4.1) with significant difference between two groups (P ＜ 0.05).The assessments of overall health status,role function,emotional function and social function from EORTC-QLQ for both groups patients were significantly different after one-year follow-up (P ＜ 0.05).The HADS scores of patient with different types of leukemia varied statistically as well (P ＜ 0.01).Conclusions Psychological intervention for patients with leukemia during treatment can relieve the symptoms of depression significantly and improve the quality of life,which is prognosis favorable.