1.Intravenous thrombolysis bridging for acute ischemic stroke
International Journal of Cerebrovascular Diseases 2017;25(2):155-159
Thrombolytic therapy is the first choice for the treatment of acute ischemic stroke,while the recanalization rate of intravenous thrombolysis for large vessel occlusion stroke is low.As a representative.of endovascular treatment,endovascular mechanical thrombectomy can effectively recanalize the occluded cerebral vessel and inprove the outcome in patients with acute ischemic stroke.This article reviews the recent research progress and the future direction of intravenous thrombolysis bridging.
2.Advancement of the clinical research in TIA
Journal of Medical Postgraduates 2003;0(10):-
Transient ischemic attack(TIA) is one frequent type of acute ischemic cerebral vascular disease.Much advancement has been made in the definition,aetiology,diagnosis and therapy of TIA in recent years.Carotid endarterectomy and carotid angioplasty and stenting is the latest therapy of carotid artery stenosis.
3.Secondary prevention of embolic stroke of undetermined source
Xinyi ZHU ; Wusheng ZHU ; Minmin MA
International Journal of Cerebrovascular Diseases 2021;29(3):210-215
Antiplatelet therapy is commonly used for the secondary prevention of embolic stroke of undetermined source (ESUS). However, the embolic source of ESUS is extremely heterogeneous, and the effect of antithrombotic therapy is different. This article describes the etiology and secondary prevention research progress of ESUS, in order to provide reference for clinical diagnosis and treatment.
4.Diagnosis and management of cervical arterial dissection
Wusheng ZHU ; Gelin XU ; Xinfeng LIU
International Journal of Cerebrovascular Diseases 2009;17(10):757-760
Cervical arterial dissection is an important cause resulting in stroke, particularly in young adults. The clinical manifestation of cervical arterial dissection may be various, and imaging examinations have a great value in the diagnosis of cervical arterial dissection. At present, anticoagulation and anti-platelet aggregation are the most important medication, while intravascular intervention is a new option for patients failed to respond to medical treatment. This article reviews the recent progress in the diagnosis and treatment of cervical arterial dissection.
5.Cerebral venous sinus thrombosis in children
Wusheng ZHU ; Gelin XU ; Xinfeng LIU
International Journal of Cerebrovascular Diseases 2010;18(10):760-763
Cerebral venous sinus thrombosis (CVST) in children has been previously regarded as a rare cerebrovascular disease. With the development of neuroimaging, we have more knowledge and understanding about CVST in children. The etiologies of CVST can be divided into infectious and noninfectious. Its clinical manifestations are various and lack of specificity. These characteristics make the clinical diagnosis of CVST have some difficulties.Now, it is considered that in combination with magnetic resonance imaging and magnetic resonance venography is the best means of diagnosis of CVST. Anticoagulation is the preferred treatment for CVST. Interventional thrombolysis, mechanical thrombectomy or decompressive craniotomy can be used for children whose symptoms continue to deteriorate after systematic anticoagulation therapy. The prognosis of CVST is relatively good if it is diagnosed and treated in time.
6.Correlation study of ankle-brachial index and proteinuria in patients with acute cerebral infarction
Juan DU ; Jiangdong CHEN ; Wusheng ZHU
Journal of Medical Postgraduates 2015;(12):1283-1286
Objective Proteinuria is in close relation with arteriosclerosis,but little investigation was made on the correlation between ankle-brachial index( ABI) and proteinuria in patients with acute cerebral infarction. Methods 271 consecutive patients with acute cerebral infarction were enrolled from January 2013 and December 2013, which were divided into 2 groups ( patients with proteinuria and patients without proteinuria) according to urine analysis.ABI of all patients was measured and stratified into 4 groups:ABI≤0.9 (low);0.9
7.Contrast Media-Related Complications and Their Management in Cerebrovascular Intervention
Gelin XU ; Wusheng ZHU ; Xinfeng LIU
International Journal of Cerebrovascular Diseases 2006;0(09):-
Endovascular intervention is an effective method in the treatment of cerebrovascular stenosis. With the advancement of techniques and improvement of equipment, the application area of this treatment is expanding and the number of patients treated is increasing. Accordingly, the use of contrast media is improving continuously in endovascular intervention. An increasing number of contrast media-related complications have also been reported. This paper briefly reviews the contrast media-related complications and their management in endovascular intervention.
8.Advances in the Treatment of Cerebral Venous Thrombosis
Wusheng ZHU ; Gelin XU ; Xinfeng LIU
International Journal of Cerebrovascular Diseases 2006;0(09):-
Cerebral venous thrombosis is a rare cerebral venous occlusive disease. Its clinical manifestations are variable, and this may lead to misdiagnosis or mistreatment. Prompt treatment is essential to improve its prognosis. This article reviews the recent treatment methods, especially the interventional endovascular treatment.
9.A study of relationship between Oxfordshire Community Stroke Project classification and middle cerebral arterial lesions among patients with acute ischemic stroke.
Huajun ZHANG ; Wusheng ZHU ; Gelin XU
Chinese Journal of Practical Internal Medicine 2006;0(24):-
Objective To study the relationship between Oxfordshire Community Stroke Project(OCSP)classification and middle cerebral artery(MCA)lesions detected by digital subtraction angiography among patients with acute MCA territorial infarction.Methods One hundred and fifty-four patients with acute MCA territorial infarction,who were obtained from Jinling Hospital during May 2002 to December 2005,were classified into total anterior circulation infarction(TACI),partial anterior circulation infarction(PACI)and lacunar infarction(LACI).Results Compared with LACI subtype,prevalence of MCA main stem occlusion in patients with TACI subtype was higher(P
10.The effect of mild hypothermia on neuronal apoptosis and Bcl-2,Bax in the focal cerebral ischemia in rats
Zhaohu CHU ; Wusheng ZHU ; Jiami WU
Journal of Clinical Neurology 1997;0(06):-
Objective To study the effect of mild hypothermia on neuronal apoptosis and Bcl 2,Bax during cerebral ischemia in middle cerebral artery occlusions(MCAO) in rats.Methods The model of MCAO was set up in rats using the Longa's way,and mild hypothermia was treated for 0.5h,1h,3h. After reperfusion(24h) the rat brains were cut into three sections for TUNEL staining and Bcl 2?Bax protein immunohistochemical staining.Results 1)The numbers of apoptotic cells and Bax cells in the mild hypothermia group(1h, 3h) decreased remarkable as compared with the control group( P