Objective To explore incidence of diabetes and the metabolic syndrome of rural residents at age of 20 years old or more in Zhongjiang County of Deyang city,and to analyze the re-lated factors.Methods Using multistage random sampling method,a total of 678 people above 20 years old were randomly selected from permanent residents from Zhongjiang County and were con-ducted with questionnaire,anthropometry index measurement and laboratory tests.SPSS statistical software was used to analyze diabetes and the metabolic syndrome.Results The incidence of dia-betes was 7.50% in Zhongjiang County above 20 years or more with 4.42% of men and 9.4% of women.Differences of correlation between gender,age,culture level,obesity,family history of diabetes,lipid metabolism and hypertension and incidence of diabetes were statistically significant (P <0.05).The incidence of the metabolic syndrome was 44.3%.In patients with diabetes, there were 40 people with metabolic syndrome and the incidence was 81.6%.Conclusion Dia-betes and the metabolic syndrome are associated with multiple factors,so prevention and control should be focused so as to reduce the incidence of diabetes and to improve the quality of life.

Objective To explore incidence of diabetes and the metabolic syndrome of rural residents at age of 20 years old or more in Zhongjiang County of Deyang city,and to analyze the re-lated factors.Methods Using multistage random sampling method,a total of 678 people above 20 years old were randomly selected from permanent residents from Zhongjiang County and were con-ducted with questionnaire,anthropometry index measurement and laboratory tests.SPSS statistical software was used to analyze diabetes and the metabolic syndrome.Results The incidence of dia-betes was 7.50% in Zhongjiang County above 20 years or more with 4.42% of men and 9.4% of women.Differences of correlation between gender,age,culture level,obesity,family history of diabetes,lipid metabolism and hypertension and incidence of diabetes were statistically significant (P <0.05).The incidence of the metabolic syndrome was 44.3%.In patients with diabetes, there were 40 people with metabolic syndrome and the incidence was 81.6%.Conclusion Dia-betes and the metabolic syndrome are associated with multiple factors,so prevention and control should be focused so as to reduce the incidence of diabetes and to improve the quality of life.

New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavirus lineage B (β-CoV-B), including SARS-CoV-2, its circulating variants, SARS-CoV and bat SARSr-CoV WIV1. Interestingly, antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibody-dependent SARS-CoV-2 spike (S) protein-mediated cell-cell fusion, suggesting a unique mode of recognition by XG014. Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional "down" conformation, while its family member XG005 directly competes with ACE2 binding and position the RBD "up". Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo. Our findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines against β-CoV-B and newly emerging SARS-CoV-2 variants of concern.
Angiotensin-Converting Enzyme 2 ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Epitopes ; Humans ; SARS-CoV-2/genetics* ; Spike Glycoprotein, Coronavirus/genetics*