[Purpose] To observe the clinical effects, relapse rate and security of treating the verruca plana with the cure warts capsules combined with Burt's res-q ointment. [Methods] Eighty patients with verruca plana were randomly divided into two groups. Forty patients in the combination group received cure warts capsules combined with Burt's res-q ointment; others in the control group received 0.1% al-transretinoic acid cream only. The courses of treatment of two groups was four weeks, then observe the number of verruca plana and bad reaction after the treatment, and record four weeks fol ow-up observation of relapse. [Results] The effective rate of treatment group was 92.50%which was significantly higher than the control group that the effective rate was 50.00% , and the former’s relapse rate was 3.40% which was significantly lower than that in the group which was 44.40% , the above showed significant difference(P<0.05).There was no significant side effects in the two groups. [Conclusion] Cure warts capsules combined with Burt's res-q ointment had better effect, low relapse rate and high safety.