2.Research progress on the relationship between triggering receptor expressed on myeloid cells 1 and 2 and malignant tumors.
West China Journal of Stomatology 2017;35(6):648-653
Increasing scientific evidence supports the positive relationship between inflammation and cancer development. The immune response initiated by pattern recognition receptors is critical to triggering of tumor-associated inflammation. Triggering receptor expressed on myeloid cells (TREM) is an immunoglobulin of the super transmembrane glycoprotein family, which is mainly expressed on select groups of myeloid cells. The most important members of TREM comprise TREM-1 and TREM-2. Activation of TREM-1 and TREM-2 signaling is initiated upon binding of their ligands. Subsequently, cross-linking reactions of downstream effectors occur, resulting in inflammation regulation. Recently, the connection between TREM and malignant tumors has been widely noticed and studied. This review summarizes studies of association between TREM-1, TREM-2, and malignant tumors in the medical field to provide new ideas for study on the correlation between periodontitis and oral cavity cancer.
3. Temporal expression of triggering receptors expressed by myeloid cells-1 during the development of experimental periodontitis in rat
Wuchao WU ; Shanshan CHEN ; Kun WANG ; Yun YANG ; Yafei WU ; Lei ZHAO
Chinese Journal of Stomatology 2018;53(3):157-163
Objective:
To illuminate the temporal expression of the triggering receptor expressed on myeloid cells-1 (TREM-1) in the experimental periodontitis in rat and to investigate the function of TREM-1 in the pathogenesis of experimental periodontitis in rat.
Methods:
The experimental periodontitis model was established in the maxillary first molar by means of 'wire ligation + vaccination periodontal pathogen