In this article,the author analyzes the major causes of diabetes at large.They can be divided into deficiency of yin,weakness of five zang organs,improper diet,intemperance in sexual life,metal stimulation,emotional stress,attack by six climate exopathogens,disoperation by toxin and pathogen,over-taken powder,transformation into dryness and damage to fluids and so on.This article offers some valuable clinical bases for the study of this kind of disease.

There was subdiscipline tendency in clinical treatment of diabetes during the Tang and Song Dynasty,and the prescription had begun to take shape,and the syndrome differentiation and treatment of the chronic diseases such as diabetes kept increasing accuracy day by day.The way of statistical analysis,which probed the regular of compatibility of prescription and drugs of diabetes in and before the Tang and Song Dynasty,could provide very valuable referenced prescription and drugs in coming Chinese clinic and scientific research.

OBJECTIVE:To investigate the effects of SDZ on LOVO cell line and the expression of E-Cadherin and N-Cadherin. METHODS: The apoptosis of SDZ on growth of LOVO cells was observed under electron microscope and inverted microscope. The expression of E-Cadherin and N-Cadherin treated by SDZ were detected by RT-PCR. RESULTS: SDZ promoted the apoptosis of LOVO cell lines and increased the expression of E-Cadherin,however,it did no effect on the expression of N-Cadherin. CONCLUSION: SDZ can enhance the intercellular adhesiveness and degrade the capability of infiltration and metastasis of tumor cells.

Determination of SCE frequency, chromosomal aberration and micronucleus rate of cultured peripheral lymphocytes of 38 miners who worked in the well, and 40 non-miners who worked outside the well in Dachang Area and 27 other workers who didn't work and live there (as control group) was carried out. The result showed that the miners had higher SCE incidence and chromosomal aberration rate. The nonmining workers and the control group had much lower rates. There was a significant difference between the miners and non-miners or control group, but no statistically differences were found between the non-miners and the control group. Micronucleus rate among the miners, the non-miners and the control group were all the same level statistically. We proposed that some toxic substances in the Dachang Tin Mine might be respousible for the genetic damages in the miners. We suggested that a combined assay of SCE with chromosomal aberration or micronucleus might be a good screening method for the high risk population such as the miners in Dachang Tin Mine.

A rapid and simple HPLC method for determination of propafenone concentration in human plasma is described. Dyclonine hydrochloride was used as an internal standard. YWG-C_(18) column(10?m)was used with a mobile phase of methanol-acetonitrile-0.05mol/L acetate buffer(pH 4.02)-diethylamine(45.5:19.5:35). Detection was performed by ultraviolet absorption at 254nm. The detection limit of propafenone waw 5ng (S/W=3)or 25ng/ml in plasma. Assay linearity was shown in a range of 50～500ng/ml with a regression coefficient of 0.9993. The recovery(n=4)was 100.5％,the CV of within-day and day-to-day being less than 3％. No interference was found from endogenous compounds or commonly used drugs. So it can be applied to pharmacokinetic studies and therapeutic monitoring.

OBJECTIVE To discuss advantages of traditional Chinese medicine(TCM)in diagnosis and treatment of chronic prostatitis(CP).METHODS To find the routes of solution concerning diagnosis and treatment of CP by comparing different points of view of TCM and Western medicine.RESULTS Under rules of treatment in TCM as Bushen,Qingre,Wenyang,Liqi and Huoxue,to apply the recipes of Zhibaidihuangyuan plus Jinkuishenqiyuan with modification,both Ying and Yang were regulated and good effects were achieved.CONCLUSIONS TCM shows its efficacy in diagnosis and treatment of CP and is practical.

As a variance of the experience and the behavior of emotion, emotional masking has been obtained in society and will be developed during all one's life. The emotional masking, which has been influenced by many facts, such as social surroundings, the family, the received education, accompanier and so on, will produce different results for the multiplicity of cognition/emotion and acts and will work on the people's physiology, psychology and social relation.

Objective: To investigate the changes of blood coagulation and fibrinolysis in patients with acute craniocerebral injuries (ACI) and to assess their relationship with patients' diagnoses and prognoses. Methods: A prospective study was performed using 528 ACI patients and 257 healthy controls taking a physical examination. The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fg), thrombin time (TT), platelet (PLT), and D-dimer (D-D) were observed within 6 h after injury. Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) were also employed and the statistical analysis was performed. Results: The incidence of abnormal blood coagulation and fibrinolysis in our group was 80.49% (425/528), with the abnormal indicators from high incidence to low were: D-D> PT> Fg> APTT > PLT>TT. (2) The levels of PT and D-D in ACI patients were significantly different from those of the control group (P<0.05); their levels increased with the aggravation of the severity of the injuries. Fg levels in the severe and moderate ACI patients were significantly different from that in the control group (P<0.05); there were no significant differences between the moderate inury group and the slight injuy group or between the slight injury group and the control group. The levels of APTT and TT were significantly different between the severe injury group and other groups(P<0.05). PLT levels were similar in all the groups. (3) Patients of GOS 1 and 2-3 had significantly increased PT, D-D levels and decreased Fg level compared with patients of GOS 4-5. Conclusion: ACI patients have abnormal coaculation and fibrinolysis function early after injury. PT,D-D and Fg are sensitive indices and may be helpful for early prediction of the injuries and prognoses.

Objective To investigate the significance of cyclooxygenase-2 (COX-2),vascular endothelial growth factor(VEGF) protein expression and angiogenesis in hepatocellular carcinoma(HCC).Methods Tissue sec- tions from 40 HCC patients were examined immunohistochemically for protein expression of COX-2 and VEGF.Mi- crovessel density(MVD) was counted by endothelial cells immunostained by anti-CD34 antibody.Results The ex- pression of COX-2 protein in well differentiated HCC was stronger than that in moderately differentiated HCC and poorly differentiated HCC(P

Objective To explore the effect of ultra-early hyperbaric oxygenation (HBO) on bone calcium, biomechanical properties and bone collagen of femur in rats with complete spinal cord transaction. Methods A total of 75 Sprague-Dawley rats were randomly divided in-to sham group (n=15), model group (n=20) and HBO group (n=40). HBO group was divided into three hours group (HBO1 group, n=20) and twelve hours group (HBO2 group, n=20). All groups underwent laminectomy at T10, while the model group, HBO1 group and HBO2 group underwent complete spinal cord transection at the same level. Three hours and twelve hours after surgery, HBO1 group and HBO2 group received HBO, respectively, for three courses with ten days in a course. After treatment, the femoral biomechanical properties, bone calcium and hydroxyproline (Hyp) were determined. The morphology of bone trabecula and the bone collagen was observed with HE stain-ing and Masson triad color staining, respectively. Results After treatment, compared with the sham group, the femoral biomechanical proper-ties, the content of bone calcium and Hyp decreased in the model group (P<0.05);compared with the model group and HBO2 group, they in-creased in HBO1 group (P<0.05). The number of bone trabecula and the bone collagen decreased, and derangement and sparseness were ob-served in the model group;however, the changes were substantially mild in HBO1 group. Conclusion Ultra-early HBO could increase the content of bone calcium and Hyp of femur, improve the morphology of the femur bone collagen, and improve the femoral biomechanical properties in rats with complete spinal cord transection.