2.Antiapoptotic Interventions in Intracerebrai Hemorrhage
International Journal of Cerebrovascular Diseases 2006;0(11):-
Tne secondary injury may occur in the perihematomal tissue after intracerebral hemorrhage(ICH).Studies have suggested that apoptosis palys an important role in the secondary injury after intracerebral hemorrhage.1he inhibition of apoptosis may significantly improve the neurological deficit after ICH.
3.Effects of Rosiglitazone on Transforming Growth Factor-?1/SMADs Signal Pathway in Diabetic Rat Myocardium and Cardiac Remodeling
Longying LI ; Qian XIAO ; Yuan GAO ; Aibin GAO ; Qinan WU ;
Chinese Circulation Journal 2004;0(06):-
Objective:To observe the effects of rosiglitazone on transforming growth factor-?1(TGF-?1)/SMADs signal pathway in dia- betic rat myoeardium(DM)and cardiac remodeling. Methods:Thirty male SD rats were randomly divided into normal control,DM and rosiglitazone groups,each having 10 rats.Diabetic rats were induced by a single intrapefitoneal injection of streptozotoein(60mg/kg).A cannula connected to a trans- ducer was inserted into the heart to measure the cardiac function.The body weight,heart weight and heart weight/body weight (HW/BW)were measured.The ultrastruetural changes were evaluated by electron microscope and collagen content was assessed by Van Gieson staining.The mRNA expression level of SMAD3 and SMAD7 were determined by RT-PCR.The protein level of TGF-?1,SMAD3 and SMAD7 were detected by immunohistochemistry. Results:Compared with the normal controls,diabetic rats experienced marked myocardium damage.Cardiac function,espe- cially diastolic function was impaired,HW/BW(P
4.Approach to the patient with subacute thyroiditis during pregnancy
Yunsong LI ; Honghua WU ; Yanming GAO ; Xiaohui GUO ; Yan GAO
Chinese Journal of Endocrinology and Metabolism 2012;28(8):673-675
Pregnant women with subacute thyroiditis (SAT) are rare.One case was reported and the clinical features and management principles of SAT during pregnancy were reviewed.In pregnant women with SAT,the illness is usually not serious.If subclinical or clinical hypothyroidism develops,L-T4 must be given and thyroid function be monitored routinely,and the medication be adjusted carefully to ensure the maternal-fetal safety.
5.Can Radix Inulae Replace Radix Aristolochiae as Medicinal Material
Weidong GAO ; Weimin LI ; Ying GAO ; Zaolian ZUO ; Lirong WU
China Pharmacy 2001;0(07):-
OBJECTIVE:To study whether Radix Inulae can replace Radix Aristolochiae as medicinal material.METHO_ DS:Comparison was made between Radix Inulae and Radix Aristolochiae in terms of plant resources,functions and indications,chemical compositions,pharmacologic actions,clinical applications,etc.by reviewing literature.RESULTS&CONCLUSIONS:Radix Inulae and Radix Aristolochiae were different in every aspect,thus the two can’t be replaced by each other as medicinal material.
6.The biological mechanisms of anhedonia in depression
Weili WU ; Xinxue GAO ; Gongying LI
Chinese Journal of Behavioral Medicine and Brain Science 2017;26(3):284-288
Anhedonia is the loss of pleasure or lack of reaction to pleasurable stimuli, which is a promising phenotype of depression. In order to explore the potential biological mechanism, the recent ad?vances were summarized from researches focused on depression with anhedonia from neuroanatomy,inflamma?tion and immunology,and molecular genetics. The structural and functional brain imaging showed that the ac?tivity in reward?related brain regions of the depressive disorder with an anhedonia was changed during re?ward?related tasks.In addition,some other genetic studies based on the related neurotransmitter,such as do?pamine, together with the findings from the researches on immunological inflammation, may shed light on finding the potential targets for novel antidepressants,besides the 5?HT.
7.Intrathoracic drainage in treatment of 43 coal worker's pneumoconiosis patients with pleural effusion and pneumothorax.
Wei GAO ; Feng LI ; Shu-hai WU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(10):618-619
Aged
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Anthracosis
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complications
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Catheterization
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Drainage
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methods
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Humans
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Male
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Middle Aged
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Pleural Effusion
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etiology
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therapy
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Pneumothorax
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etiology
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therapy
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Retrospective Studies
8.Epigenetic regulation and human common diseases
Yanhong GAO ; Dingguo LI ; Chaoqun WU
Journal of Shanghai Jiaotong University(Medical Science) 2009;29(10):1256-1258
In the past few years,it has been disclosed that identified epigenetic processes and epigenetic changes are involved in human diseases.Disorders of these processes may influence chromatin structure and gene expression,which may result in complicated syndroms,multiple-factor diseases and cancers. The researchprogress of epigenetic processes of several diseases is reviewed in this paper.
9.CHANGES OF PLASMA ADRENOMEDULLIN AND ADRENOTENSIN CONCENTRATIONS IN PATIENTS WITH CONGESTIVE HEART FAILURE
Yuqi GAO ; Zhiliang LI ; Hongchao WU
Medical Journal of Chinese People's Liberation Army 1982;0(03):-
To investigate the changes of plasma adrenomedullin(ADM) and adrenotensin(ADT) levels and their clinical significance in the pathological process of congestive heart failure(CHF), plasma levels of ADM and ADT in 45 patients with CHF before and after treatment were measured by specific radioimmunoassay. The results indicated that before treatment, plasma levels of ADM in class Ⅱ and Ⅲ CHF patients were 51.46?4.52pg/ml, 70.39?3.22pg/ml and plasma levels of ADT in class Ⅱ and Ⅲ CHF patients were 29.98?1.13pg/ml, 33.45?0.91pg/ml, respectively,which were higher than those of the control subjects(24.12?1.59pg/ml and 24.89?2.19pg/ml, respectively)(P
10.Changes of plasma levels of proadrenomedullin N-terminal 20 peptide in patients with congestive heart failure
Yuqi GAO ; Zhiliang LI ; Hongchao WU
Chinese Journal of Practical Internal Medicine 2001;0(05):-
Objectives To study the changes of plasma levels of proadrenomedullin N terminal peptide(PAMP) in patients with congestive heart faillure(CHF) before and after drug treatment and its significance.Methods Plasma PAMP levels in 45 patients with CHF and 7 heathy control subjects were measured by specific radioimmunoassy.Results The plasma PAMP levels in patients with CHF were significantly decreased with the deterioration of cardiac function.Plasma PAMP levels in 45 patients in NYHA class Ⅳ(2 79?0 89pg/mL) were significantly lower than those in class Ⅱ(6 24?1 71pg/mL)?class Ⅲ(7 38?1 28pg/mL) and control subjects(8 56?2 44pg/mL)(P