Objective To investigate the clinical efficacy of alanyl glu-tamine injection on the prevention and treatment of chemotherapy -in-duced oral mucositis in patients with malignant lymphoma.Methods A total of 130 cases suffering from chemotherapy of malignant lymphoma were divided into treatment group(n=65) and control group(n=65).Both groups were given sodium bicarbonate solution gargled.Patients in control group were given 12.5% sodium bicarbonate solution gargle, 3 times a day.And patients in treatment group were given alanine gluta-mine injection 20 g· d -1 for 1 week on the basis of control group.After the chemotherapy cycle, the incidence of oral mucositis and stomatitis cure time were compared between the two groups.Results The chemo-therapy-induced oral mucositis rate were 35.38%and 46.15%in treat-ment group and control group, with statistical difference( P<0.05).The cure time for grade Ⅲ chemotherapy -induced oral mucositis were (8.25 ±0.96), ( 11.17 ± 1.47 ) d, with statistical difference ( P<0.05).There was no drug related adverse reaction during the treat-ment.Conclusion Alanyl glutamine injection combined with sodium bi-carbonate gargled has a significantly preventive and therapeutic effect on chemotherapy-induced oral mucositis in patients with malignant lymphoma.

Objective:To analyze the biological characteristics, phylogenic features and clinical significance of SQ219 and SQ220 isolated from clinical sputum and midstream urine specimens.Methods:The culture and biochemical characteristics of the two strains were observed. VITEK2 System, drug sensitivity testing and MALDI-TOF mass spectrometry were used for bacterial identification. Phylogenetic analysis based on 16S rRNA and core genome was performed. The average nucleotide identity (ANI) based on whole genome sequences was calculated.Results:SQ219 and SQ220 were Gram-stain-negative, aerobic, catalase- and oxidase-positive, and non-motile bacteria. Their optimum growth was observed in NaCl-free medium at 30℃ and pH7. Flexirubin-type pigments were produced by SQ220 on Colombia blood agar, but not by SQ219. Both SQ219 and SQ220 were resistant to aztreonam, amikacin, tobramycin and colistin, which was consistent with the drug resistance phenotype of genus Chryseobacterium. The genome sequences of SQ219 and SQ220 were 5.08 Mb and 4.80 Mb in length, and the G+ C contents were 36.72% and 36.36%, respectively. Both strains carried β-lactam resistance gene ( blaCGA). 16S rRNA phylogenetic analysis showed that SQ219 and SQ220 were closely related to Chryseobacterium gambrini DSM18014 T with the similarities of 98.93% and 98.36%, respectively. Core genome phylogenetic analysis revealed that SQ219 and SQ220 were highly homologous to Chryseobacterium gambrini DSM18014 T. However, the ANI values between the two strains and Chryseobacterium gambrini DSM18014 T were 92.49% and 93.27%, respectively, below the threshold for prokaryotic species identification. Conclusions:Based on the phenotypic and phylogenetic data, SQ219 and SQ220 represent a novel species of the genus Chryseobacterium. This study would help promote the understanding of the evolution of Chrysobacterium and provide reference for the identification of new species of Chrysobacterium.