Objective To explore the curative effect of loop electrosurgical excision procedure (LEEP) on cervical intra-epithelial neoplasia(CIN) infected with high risk human papilloma virus (HR-HPV).Methods 80 CIN patients with HPV infection underwent LEEP were selected.HR-HPV DNA load was detected before operation and 3 months after operation,and at the same time,vaginal examination and cervical directed biopsy were conducted.Results Before LEEP operation,the differences between different levels of CIN HPV load were not significant(P ＞0.05,F =0.45).3 months after operation,CIN Ⅰ grade 19 cases (86.4％) turned to chronic inflammation,CIN Ⅱgrade 36 cases (83.7％) turned to chronic inflammation,CINⅢ grade 13 patients (86.6％) were chronic inflammation.Cervical HPV load postoperatively negative rate was 85％ and the lower HPV load,the higher postoperatively negative rate.Conclusion LEEP is the effective treatment for cervical lesion and can significantly decrease the HPV-DNA loading at cervix.

Objective To investigate the method of early termination of cesarean scar pregnancy (CSP).Methods Clinical data of 12 patients with CSP were retrospectively analyzed,all patients were treated with mifepristone 25mg in the morning and evening for 3 days,and misoprostol 600μg in the morning at the fourth days.Results Of 12 patients,medical abortion were completely in 4 cases,and 6 cases were failure which were carried out painless abortion with microtubules(disposable suction tube).2 cases were taken curettage because of hemorrhage after incomplete abortion.1 case was improved by massage the uterus,and intramuscular injection of oxytocin 20u in cervix;another one case was taken uterine artery embolization because of postoperative bleeding about 2 000ml with shock symptoms.Conclusion The CSP is complicated,the early prevention and treatment must be taken for it,and once it diagnosed,the termination of pregnancy should be immediately taken,in patients with a history of cesarean section line miscarriage may occur when the hard-to-control bleeding.Uterine artery embolization is an effective treatment method for the first choice.

Through PubMed, CNKI and other databases to retrieve original documents about the maintenance treatment of advanced colorectal cancer, collect and analyzed research theory and progress in the maintenance treatment of advanced colorectal cancer. The clinical efficacy of maintenance therapy are evaluated and the patient's disease-free survival and quality of life are observed. The Result shows that the maintenance treatment can improve disease-free survival of advanced colorectal cancer patients, and the toxicity of maintenance treatment can still be tolerated. So the maintenance treatment of advanced colorectal cancer has better clinical efficacy, it is worth to study in the future.

Objective To evaluate the effects of selective mesenteric angiography with continuous papaverine perfusion for the diagnosis and treatment of non-occlusive mesenteric ischemia(NOMI).Methods Eighteen patients with NOMI underwent selective superior mesenteric arteriography and papaverine perfusion via the SMA simultaneously were analized retrospectively.Results Fifteen out of the 18 cases recovered;2 cases underwent laparotomy;1 case died within 10 days.Conclusion Selective superior mesenteric arteriography with continuous papaverine perfusion is an effective diagnostic and therapeutic method for non-occlusive mesenteric ischemia.(J Intervent Radiol,2006,15:209-212)

Cervical artificial disc replacement (CADR) as a new method for the treatment of cervical spondylosis, is becoming a basic and clinical research. Compared with the anterior cervical discectomy and fusion (ACDF), the biggest difference of CADR lies in the reconstruction of the cervical vertebra height and physiological curvature, retaining the spinal physiological function maximally and reducing the degenerative changes in adjacent segments. A large number of clinical investigation have suggested that ACDR can become an operation method to replace the ACDF. However, the complications and the problems of prosthesis itself are gradually exposed, such as that the prosthesis, can't completely simulate the biological effects of human intervertebral disc, the other factors and including the operation methods and prosthesis itself. At the same time, the problem that how to prevent complications and problems is required to be solved. Whether, the effect of CADR on the activity of the operation segment, and the prevention of adjacent segment degeneration can be guaranteed for a long time has drawn more and more attention from scholars.
Cervical Vertebrae ; surgery ; Humans ; Postoperative Complications ; etiology ; Total Disc Replacement ; adverse effects

Objective:To explore the clinical effect of glucocorticoid methylprednisolone combined with the conventional treatment on severe hand-foot-mouth disease ( HFMD) in children. Methods:One hundred and twenty children with severe HFMD from our hos-pital were randomly divided into the hormone group and non-hormone group with 60 cases each. The non-hormone group was treated with western routine therapy, and the hormone group was treated with glucocorticoid methylprednisolone 2mg·kg-1 ·d-1 additionally. The changes in such symptoms as fever, rash, surprised and chatter, drowsiness and shock were recorded in all cases. The disappear-ance time of febrile, shock and herpes and hospital stay were compared between the two groups. Results:The clinical effect of the hor-mone group was better than the non-hormone group;it could shorten the disappearance time of febrile, shock, herpes and pharyngeal buccal redness (P<0. 05), while showed no effect on the hospital stay. Conclusion:Glucocorticoid combined with the routine thera-py in the treatment of severe HFMD in infants exhibits better clinical effect.

Objective To study clinical therapeutic effect of endovascular embolization on cerebral arteriovenous malformation(cAVM). Methods In digital subtraction angiography (DSA), 23 patients suffering from cAVM were treated by endovascular embolization with NBCA through microduct technique. 6 cases were embolizated only one time, and 17 cases more than one time. 11 patients were treated with gamma knife after embolization. Results Among 23 patients, 6 cases of cAVM were embolizated completely, 4 cases more than 95%, 9 cases 75% to 95%, and 4 cases less than 70%. 3 patients occurred dizziness and headache after embolization. All patients were followed up after treatment, 4 cases had seizure, and the others' symptoms were obviously improved. Conclusion Endovascular embolization was a safe and effective method for treating cAVM, and combination of embolization and gamma knife could improve the clinical efficiency.

Objective To explore the etiology of and timing for operation of acalculous biliary acute pancreatitis(ABAP).MethodsWe retrospectively analyzed the etiology study and treatment experience of 38 cases of ABAP.ResultsThirteen cases underwent a surgery, including 6 early operations for complicated biliary tract infection without morbidity and mortality, 5 middle staged patients (5～14 days after onset of ABAP) underwent surgery because of intraabdominal indications with one postoperative death and 2 late operations for severe acute pancreatitis (SAP) resulted in one postoperative death of sepsis. The total postoperative mortality rate was 15%( 2/13). Four SAP cases were managed conservatively with one death of MOF. The remaining 21 cases of acute edematous pancreatitis (AEP) were cured by nonoperative methods.ConclusionWhereas an early exploration is indicated, when complicated by biliary tract infections, it is judicious to try a conservative therapy first for ABAP patients.