Human metapneumovirus (HMPV)is a recently discovered virus associated with respiratory tract infection. Most infections with HMPV occurred during winter and spring. Children, elderly subjects and immunosuppressed hostsare susceptible. The consequences of HMPV infections ranged from mild upper respiratory tract infection to severe bronchiolitis or pneumonia. There are three different kinds of methods for the diagnosis of HMPV infections, detection of virus antigen-antibody, virus isolation by culture, and RNA detection by reverse transcription-PCR. Symptomatic therapy is the main method of treatment.

[Objective] To investigate the antibiotic resistance and nosocomial infections status of Staphylococcus aureus(SAU)and provide scientific evidence for disease diagnosis and reasonable use of antibiotics.[Methods]The clinical isolates were identified by VITEK-2 compact.AST-GP61 was used to detect the antibiotic susceptibility.[Results] Among 310 S.aureus isolates,SAU was isolated from ICU and department of dermatology,from sputum/throat and secretion.The drug sensitivity rate to glycopeptide antibiotics and linezolid was 100%,the incidence of oxacillin-resistant S.aureus was 53.1%.[Conclusions] S.aureus showed multidrug resistance to the commonly used antibiotics,while curing infections caused by oxacillin-resistanct S.aureus,Vancomycin,teicoplanin and linezolid were the best choice.

HL-60 cells treated with 80?g/ml notogensenosidc R_1, were induced to granulocytic differentiation to 68% (among which metamyelocytes 32%, banded neutrophils 30% & segmented neutrophils 6%). Further experiment showed that the ability of the cell to reduce nitroblue tetrazolium (NBT) dye, phagocytosis, as complement receptors and activities of acid phosphatase and ?-glucuronidase were all enhanced after differentiation. There were significant differences between the treated groupand the control group in NBT positive rate (62% v. s. 10%, P

The abnormal expression of gastrins and their receptors have close relationship with the occurrenceand the development of some colorectal neoplasms.The high expression of gastrins and their receptors promote colorectal neoplasms cell proliferation and inhibit apoptosis.The biological behavior is mainly rely on the abnormal expression of protein.Using differential proteomics can screen differential expression protein of high expression of gastrin-based colorectal neoplasms in the occurrence and development process,and then with the regulation of specific proteins to achieve the prevention and treatment of colorectal neoplasms purposes.

0.05).Conclusion:The diabetes itself does not affect the sulfonylurea receptor(SUR2)expression in myocardial tissues.Sulfonylureas at treatment dosage have no effect on receptor expression of SUR2.

The growth hormone(GH)-insulin-like growth factor(IGF)-I axis is an important modulator of growth and development.In addition to the classical role as endocrine hormones,the components also regulate a wide range of biological functions through paracrine and autocrine mechanisms.Their potent mitogenic and anti-apoptotic effects play a critical role in the regulation of rapidly renewing epithelial cell populations such as those found in the colon.Recent epidemiological evidence from acromegaly patients suggests an association between inappropriate regulation of the GH-IGF-I axis and the development of colorectal cancer.However,the molecular mechanisms and signalling pathways responsible are only beginning to be unravelled,as are the relative contributions of the endocrine and autocrine or paracrine effects.

OBJECTIVE:To investigate the effects of minocycline on clinical indexes,inflammatory factors and blood glucose of patients with moderate and severe chronic periodontitis complicated with type 2 diabetes(T2DM). METHODS:A total of 125 patients with moderate and severe chronic periodontitis complicated with T2DM selected from our hospital during Feb. 2013-Aug. 2015 were divided into control group(63 cases)and observation group(62 cases)according to random number table. Both groups were periodental non-surgical treatment as scaling and root planning. Control group was given iodine glycerin to fill periodontal pockets after surgery,2-4 times/d. Observation group was given Minocycline hydrochloride ointment,once a week,after surgery. Both groups were treated for 4 weeks. The levels of clinical indexes [probing depth,clinical attachment level(CAL),probing bleeding rate],serum inflammatory factors(CRP,TNF-α)and blood glucose(fasting blood glucose,glycosylated hemoglobin) were observed in 2 groups before treatment,3 months after treatment,and the occurrence of ADR was recorded. RESULTS:Be-fore treatment,there was no statistical significance in clinical indexes,serum inflammatory factors and blood glucose levels be-tween 2 groups(P>0.05). Three months after treatment,probing depth,probing bleeding rate and serum inflammatory factor lev-els of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statisti-cal significance(P<0.05). Compared to before treatment,CAL of 2 groups were increased,without statistical significance before and after treatment or between 2 groups(P>0.05). The levels of fasting blood glucose in 2 groups were decreased,with statistical significance(P<0.05),but no statistical significance between 2 groups(P>0.05). Compared to before treatment,the level of glycosylated hemoglobin in control group was decreased,without statistical significance(P>0.05);the level of glycosylated hemo-globin in observation group was decreased significantly,and the observation group was significantly lower than the control group, with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between observation group (3.23%) and control group (0)(P>0.05). CONCLUSIONS:For moderate and severe chronic periodontitis complicated with T2DM,minocycline effectively improves clinical indexes of periodontitis,reduces serum inflammatory factors and blood glucose with good safety.

Objective The goal of this work is to evaluate the dosimetric characteristics of a new 2D diode array (Mapcheck from Sun Nuclear Corporation,Melbourne,Florida) and assess the role it can play in routine IMRT QA. Methods Fundamental properties of the Mapcheck such as reproducibility and linearity were studied for high-energy photon beams. Clinical performance of the MapCheck for relative and absolute dosimetry was demonstrated with head and neck IMRT plans,and compared with plan dose distribution. Absolute dose measured by Ion chamber and Mapcheck are compared with the one given in TPS. Results The Mapcheck offers the dosimetric characteristics required for performing both relative and absolute dose measurements. Conclusion Mapcheck can provide the verification of absolute dose and relative dose. Its use in the clinic can simplify and reduce the IMRT QA workload.

ObjectiveTo explore the clinical value of ultrasound in the diagnosis of chest wall tuberculosis.Methods134 cases of chest wall tuberculosis were diagnosed with ultrasound and the correlation with CT,X-ray diagnostic results were studied.ResultsThere were solid echo type 27 cases; liquid dark area type 42 cases and combined echo type 65 cases.There was statistical significant difference between ultrasound and CT diagnosis of calcification within the lesion and the crab-like sinus(P＜0.05).The specificities of ultrasound and CT diagnosis of chest wall tuberculosis were 95.52％ and 93.28％,respectively,and the difference was not statistically significant (P＞0.05).ConclusionUltrasound diagnosis of chest wall tuberculosis has clinical value on determining the size of chest wall nodule,its range,and its relationship with the surrounding tissue.It is an effective diagnostic method of chest wall tuberculosis.