1.Pars plana vitrectomy for eye injuries in children with posterior segment involvement
Ophthalmology in China 1993;0(04):-
To evaluate the role and efficacy of vitrectomy in the treatment of eye injuries in children with posterior segment involvement, forty-six eyes in 45 children aged under 16 with injuries involved posterior segment treated with pars plana vitreetomy are studied retrospectively. Six eyes underwent vitreetomy only, the others combined with seleral buekling and/ or gas-fluid exchange, and rarely, silicon oil tam-ponade; Seventeen eyes with lensectomy. Thirty-four (73.91%) of the 46 eyes achieved surgical success. Of 13 (28.26%) eyes with retinal detachments, six (46.15%) achieved reatachment. The failure of surgery was mainly due to retinal detachment, which mostly characterized by anterior proliferative vitreoretinopathy (PVR). We conclude that pars plana vitrectomy is an important therapeutic operation for eye injury in children with posterior segment involvement. The key factor that influence the outcome of eye injury in children is the treatment of traumatic retinal deatchment.
2.Clinical analysis of traumatic scleral rupture
Ophthalmology in China 1993;0(03):-
Clinical analysis of 42 cases of scleral rupture revealed that the injures were caused by blunt objects in 42.9% and by sharp objects in 38.1% of the cases. The wound was mostly on the nasal side of the eye (71.43% OD) and (78.95% OS) with no correlation to the causes. The concurrent manifestations included hyphema (63.4%), posterior uveal or vitreous prolapse or vitreous heamorrhage (52.3%), and lens opacity or missing (over 21.4%). Enucleation was performed in 9 cases,of which 7 cases followed blunt contusion. The indications for enucleation were that the scleral wound extending posteriorly beyond the rectus muscle insertions or≥10mm in length,visual acuity≤LP, hyphema, lens dislocated or missing and vitreous heamorrhage.
3.Nocardia asteroides endophthalmitis
Ophthalmology in China 1993;0(03):-
Nocardia asteroides endophthalmitis is a rare and severe intraocular bacterial infection.In this paper we present the first reported ease in China,to our knowledge,of chronic suppurative endophthalmitis caused by Nocardia asteroides after ocular perforative trauma.Cases of exogenous Nocardia endophthalmitis in foreign literature are reviewed,and the clinical characteristics,diagnosis,treatment,as well as prognosis of exogenous Nocardia endophthalmitis, are extensively discussed.
4.Current management of submacular hemorrhage in age-related macular degeneration
International Eye Science 2008;8(5):867-870
Submacular Hemorrhage (SMH) in age-related macular degeneration (AMD) represents a challenging disorder for vision protection. Varied surgical interventions have been suggested in its management. The author herein reviewed some aspects related to SMH in AMD such as its risk factors, secondary damages, natural course and surgical management including different techniques,outcomes and complications.
5.Effect of rhIFN-a on Ultrastructure of Hypertrophic Scar Fibroblasts
Journal of Kunming Medical University 1989;0(01):-
Objective To investigate effects cytokine of rhIFN-a and their on ultrastructure of hypertrophic scar derived fibroblasts and explore its mechanism.Methods Hypertrophic scar fibroblasts cultivated in vitro were observed and analysed through transmission elextron microscope(TEM).Then the effects of rhIFN-a on biological behavior and pathological changes of hypertrophic scar fibroblasts have been determined.(Results) Compared with the control group,the experimental rhIFN-a group could be observed changes in inhibition of fibroblasts growth and proliferation with the mitochondrion swelling,its ridge dissolving and apoptosis promoting.Conclusions rhIFN-a can suppress growth and proliferation of hypertrophic scar fibroblasts and promotes apoptosis.This indicates that ,as a negative modulation factor,rhIFN-a is important in the treatment of hypertrophic scar.
6.Growth factors-mediated effects on the differentiation of human adipose-derived stem cells into chondrocytes.
Journal of Biomedical Engineering 2014;31(6):1409-1413
In recent years, there has been a growing emphasis on use of human adipose-derived stem cells (hADSCs) for cartilage tissue engineering owing to their ability to differentiate into chondrocytes, which is mainly induced by growth factors (GFs). In general, GFs for chondrogenic induction come from the transforming growth factor beta (TGF-beta) superfamily. To date, the most commonly used GFs for chondrogenes is TGF-beta1/3. However, the response of hADSCs to GFs may differ significantly from that of human bone marrow stem cells (hBMSCs). It has been reported that bone morphogenetic protein-6 (BMP-6) treatment induced TGF-beta receptor-I expression of hADSCs. It seems that these two cell populations varied strongly in their potency to undergo chondrogenesis in the same medium conditions. Here, we provide a concise review on various GFs used in chondrogenic differentiation of hADSCs in vitro.
Adipocytes
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cytology
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Cartilage
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Cell Differentiation
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Chondrocytes
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cytology
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Chondrogenesis
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Humans
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Stem Cells
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cytology
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TGF-beta Superfamily Proteins
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Tissue Engineering
7.The expression and clinical significance of ICAM-1 and VCAM-1 in colorectal carcinoma
Acta Universitatis Medicinalis Anhui 2015;(8):1124-1127
Objective To investigate the expression of ICAM-1 and VCAM-1 in colorectal carcinoma and the rela-tionship between ICAM-1, VCAM-1 and the occurrence, the metastasis of colorectal carcinoma, and to analyze the significance. Methods Immunohistochemistry staining(S-P method) was used to detect the expression of ICAM-1 and VCAM-1 on consecutive section in 78 cases of colorectal carcinoma and normal mucosa and 42 cases of colorec-tal adenomas. Plasma was obtained from 78 patients with colorectal carcinoma and 40 healthy volunteers prior sur-gery, by an enzyme-linked immunosorbent assay (ELISA). Results There was significant difference between the high expression of ICAM-1 and VCAM-1 in colorectal carcinoma and the low expression in normal mucosa and ade-noma(P < 0. 01). Serum ICAM-1 and VCAM-1 were significantly higher in patients with colorectal carcinoma than those in normal control group(P < 0. 01). The ICAM-1 and VCAM-1 levels were not related to sex, age, tumor lo-cation and histological grades(P > 0. 05),but had significantly statistical difference between lymph node metastasis and Dukes stage(P < 0. 01). Conclusion The increase expression of ICAM-1 and VCAM-1 in colorectal cancer suggests that the ICAM-1 and VCAM-1 may play an important role in evaluation of malignant degree and judging the progress as well as the mechanism of colorectal cancer.
8.Progress of ovulation induction in female hypogonadotropic hypogonadism
Chinese Journal of Endocrinology and Metabolism 2015;31(1):83-85
[Summary] Hypogonadotropic hypogonadism (HH) in women is characterized by failure of ovarian function secondary to deficient gonadotropin secretion,resulting from either a hypothalamic or pituitary defect.Estrogenprogestin therapy can induce and maintain secondary sex characteristic and artificial menstrual evcle.If the patient requires fertility,ovulation and even pregnancy can be induced either with exogenous gonadotropins or with pulsatile gonadotropin releasing hormone therapy.In the present article,different ovulation induction therapies of female HH were reviewed.
9.Extent and disputes about radical resection for pancreatic head carcinoma
Chinese Journal of Digestive Surgery 2015;14(8):615-618
Pancreatic carcinoma is a high malignancy,as radical resection is the only cure for long-term survival.In an attempt to improve outcomes and prognosis,surgeons over the decades have employed various active surgical strategies to combat this disease.Through document analyses of radical pancreaticoduodenectomy for pancreatic head carcinoma,regional lymphadenectomy,retroperitoneal nerve dissection,and combined vessel resection,the extent and disputes about radical resection for pancreatic head carcinoma are investigated.Total mesopancreas excision appears to be a novel and promising surgical procedure for the improvement of prognosis of patients with pancreatic head carcinoma.However,further studies based on the data of larger number of patients are mandatory to raise the evidence for this surgical procedure.
10.The application of N-terminal pro-B-type natriuretic peptide, C-reactive protein and D-dimer in evaluating prognosis of elderly patients confined to bed
Chinese Journal of Postgraduates of Medicine 2013;36(28):16-19
Objective To evaluate the value of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP),C-reactive protein(CRP) and D-dimer(D-D) in prognosis of elderly patients confined to bed.Methods The clinical data of 150 elderly patients confined to bed were reviewed retrospectively,and 35 patients were in dead group and 115 patients were in survival group.The level o f plasma NT-proBNP,CRP and D-D were measured before treatment,during treatment and after treatment.Their characteristics and dynamic change were analyzed,and the value of NT-proBNP,CRP and D-D was evaluated in prognosis of elderly patients confined to bed.Results The level of NT-proBNP,D-D and CRP in dead group before treatment,during treatment and after treatment were significantly higher than those in survival group (P < 0.05 or < 0.01).The peak level of NT-proBNP,D-D and CRP in dead group emerged after treatment.By the way,the peak level of NT-proBNP,D-D and CRP in survival group emerged before treatment.Incidence of two or three markers positive in dead group [37.1% (13/35),54.3% (19/35)] was significantly greater than that in survival group [20.9% (24/115),8.7% (10/115)] (P =0.032,0.008).Multivariate Logistic regression analysis showed that the level of NT-proBNP,D-D and CRP were independent predictors of 28-day mortality (P <0.05).Conclusions The level of NT-proBNP,CRP and D-D are increased in severe elderly hospitalized patients.The level of above indexes have a dynamic change and reach peak before death.They are the independent prognostic markers of hospital mortality.Combined detection of NT-proBNP,D-D and CRP can improve the predictive value of hospital mortality in elderly patients confined to bed.