Objective To study the expression ofinterleukin 10(IL-10) and interleukin 17(IL-17)in patients with acute gastritis,and analyze the clinical significance.Methods The expression of IL-10 and IL-17 in the serum of 58 patients with acute gastritis (gastritis group) and 40 healthy cases (control group) was detected by ELISA.The patients in gastritis group included 23 patients of slight degree,18 patients of middle degree and 17 patients of severe degree.Results The level of IL-10 in gastritis group [(108.321 ±12.302) ng/L] was significantly higher than that in control group [(17.883 ± 13.802) ng/L] (t =18.143,P ＜ 0.01).The level of IL-17 in gastritis group [(127.418 ± 11.410) ng/L] was significantly higher than that in control group [(30.335 ± 14.549) ng/L] (t =22.493,P ＜ 0.01).The level of IL-10 and IL-17 in slight degree,middle degree and severe degree patients was significantly increased [IL-10:(33.486 ± 14.568)ng/L,(106.189 ± 13.583) and (123.875 ± 14.892) ng/L;IL-17:(68.209 ± 9.332),(129.856 ± 11.456),(208.165 ± 12.854) ng/L](P＜ 0.05).The level of IL-10 had positive correlation with IL-17 (r =0.79,P＜0.01).Conclusions IL-10 and IL-17 participate in the pathogenesis of acute gastritis and they have high correlation.IL-10 may restrain IL-17 cells and control the progress of inflammation.

AIM: To establish a method of determining the content of total saponin of Radix et Rhizoma Notoginseng in buccal tablets by HPLC. METHODS: Chromatographic conditions are as follows:Hypersil NH_2 column(4.6 mm?200 mm,5 ?m) as the stationary phase,acetonitrile-1% phosphate buffer solution(0-10 min,20:80;10-20 min,25:75;20-25 min,45:55;25-30 min,50:50) as the mobile phase,the velocity of flow is 1.0 mL/min,the temperature of coloum is 35(?C) and the detection wavelength is 203 nm. RESULTS: The HPLC method has good linearity in determining the total saponin of Radix et Rhizoma Notoginseng content,and we can detect four saponins at the same time,linear range,ginsenoside Rg1 0.093 75-6 ?g,ginsenoside Re 0.011 72-0.75 ?g,notoginsenoside R1 0.023 44-1.5 ?g and ginsenoside Rb1 0.140 6-9 ?g,the correlation coefficient r=0.999 9. CONCLUSION: The established method in this article is simple and convenient,with good reproductivity.We can detect four saponins in the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets at the same time by this method.It can be used for quality control of the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets.

Objective To investigate and analyze the depression situation and the influencing factors in elderly inpatients.Meth-ods The cross-sectional method was used to conduct the investigation on randomly selected 125 elderly inpatients by the geriatric depressive scale(GDS)and the general personal questionnaire.Results Among 125 elderly inpatients,41 cases were depressed eld-erly inpatients,accounting for 32.8%.Disease,marital status,length of hospital stay,self-care ability,medical expenses and hobbies were the influence factors of the elderly inpatients(P<0.05).Conclusion The prevalence of depression in the hospitalized elderly patients is relatively high,the geriatrics should pay attention to it.

ObjectiveTo study the effect community health education on the quality of life in chronic obstructive pulmonary disease (COPD) patients.Methods Three hundred and sixty patients with COPD in remission were set as the observation group, while another 212 COPD patients during the same period as the control group.The control group received conventional health education and the obseravation group received systematic,targeted health mode.The two groups were compared in respect of the quality of life.Results Before intervention,the two groups showed no significant differences in the total score on quality of life as well as its dimensions (P>0.05).After intervention,the study group was higher than the control group in the total score on quality of life as well as its dimensions (P<0.05).Conclusion The community health education is effective for improving the quality of life of COPD patients.

In recent years,it is a tendency to substitute acute kidney injury (AKI) foracute renal failure (ARF)in the aspect of international nephrology and emergency medicine.Compared with the past,the causes for AKI in children at present has been transferred from primary kidney disease to multi-factors,moreover,the morbidity and mortality of AKI is staying at a high level.From the perspective of epidemiology this paper briefly analyses the common cause,mortality and morbidity of AKI in children.

Objective To determine the value of soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) in patients with stable chronic obstructive pulmonary disease (sCOPD). Methods From 2015 January to 2015 August, 101 patients with stable chronic obstructive pulmonary disease and 81 healthy controls were en-rolled. All subjects underwent pulmonary function test to record FEV1%pred and FEV1%FVC and their serum sTREM-1 levels were determined. Arterial blood gas analyses and COPD assessment tests were also conducted in stable COPD patients. Results Serum sTREM-1 levels were significantly higher in stable COPD patients than healthy controls (113.2 ± 31.5 pg/mL and 83.8 ± 17.9 pg/mL respectively, P=0.000). sTREM-1 levels were posi-tively correlated with CAT score (r=0.507, P=0.000), whereas negatively correlated with FEV1%pred and PaO2 (r = 0.507, P = 0.000; r = 0.439, P = 0.000). Conclusion sTREM-1 is a promising biomarker to evaluate sCOPD in the future.

Objective To observe the effects of alendronate sodium and alfacalcidol on the parameters of atherosclerosis in old women with type 2 diabetes mellitus(T2DM ) complicating osteoporosis .Methods 28 old women with T2DM complicating osteopo-rosis were taken as the osteoporosis group and 25 old women with T2DM and without osteoporosis were taken as the control group .Alendronate sodium(70 mg/week) and alfacalcidol(0 .5 μg/d) were given to the osteoporosis group for 12 month .The pa-rameters of the bone mass density (BMD)of femoral neck and ,T value ,arkle brachial index (ABI) ,cardio-ankle vascular index (CAVI) and carotid artery intima-media thickness(IMT) ,blood fat and glycosylated hemoglobin were observed .Results Com-pared with the control group ,BMD ,T value and ABI in the osteoporosis group were significantly decreased (P<0 .01) ,while CAVI and IMT were obviously increased(P<0 .05) .Compared with before treatment ABI ,CAVI and IMT after 12 month treatment in the osteoporosis group had no significant changes ,but BMD and T value of femoral neck and ward triangle area were significantly increased(P<0 .05) ,the atherosclerosis degree after 12 months in the control group was significantly aggravated (P<0 .05) .BMD and T value had no obvious change .Conclusion Alendronate sodium combined with alfacalcidol for treating T 2DM complicating os-teoporosis can improve the atherosclerosis parameters and has certain role in preventing and treating cardiovascular and cerebrovas-cular diseases .

Juvenile idiopathic arthritis (JIA) is the most common chronic arthropathy in childhood. Immune and genetic factors take part in the development of JIA and influence its consequence. Studies have identified association between JIA and genes encoding the human leukocyte antigens (HLA) . In this article we discuss the principles behind genetic studies of complex traits like JIA, and comprehensively catalog HLA candidate gene associated with JIA to date, and review several validated associations. Studies indicate that the HLA-Ⅰ, Ⅱ gene and their products play an important role in JIA pathogenesis, clinical course, hormonal effect and prognostic judgment. Studies in different ethnic groups indicate the main relationship between JIA and HLA is concentrated upon A, DR and DQ loci, especially the HLA-Ⅱ gene and some haplotypes. The different type of JIA is always with different HLA susceptible locus and protective locus. Different race, different region and different social environment also affect the JIA's susceptible gene polymorphism. Finally we discuss the problems existed in the study of JIA susceptibility and HLA polymorphism.

Objective To observe the effect of Xuebijing injection on organs injury in patients with acute paraquat poisoning.Methods Thirty patients with paraquat poisoning were randomly divided into two groups.The improvement of liver and kidney function,SaO2,rate of death were observed and compared between the two groups.Results The ABG,SaO2,GGT and Crea were all improved significantly in the treatment group than control group.At last,two patients gave up their treatment,nine cases were cured,four cases died in treatment group.One patient gave up treatment,four cases were cured,ten cases died in control group.The total effective rate of the treatment group and control group was 60.0％,26.7％,the difference was significant(x2 =4.75,P＜0.05).Conclusion Xuebijing injection has very good clinical effect in multiple organ failure of paraquat poisoning,it is worthy of clinic application.

The immunopathogenesis of IgA vasculitis and IgA nephropathy both demonstrate IgA deposition,and abnormal glycosylation of IgAl molecule is their major pathogenesis.Therefore,it is clinically controversial that they are actually one disease.The present text will delineate their similarities and differences from aspects of epidemiology,clinic,pathology,mechanism and prognosis.