Objective:To evaluate the efficacy of computed tomography (CT)-guided implantation of radioactive ~(125)I seeds in the treatment of residual foci of nasopharyngeal carcinoma after radiotherapy.Methods:Twenty-five nasopharyngeal carcinoma patients who had residual foci after radiotherapy were implanted radioactive ~(125)I seeds from January 2007 to January 2008 in our hospital. Three-dimensional treatment planning system (TPS) was used to calculate the quantity and total dosage of ~(125)I seeds. The radioactive ~(125)I seeds were implanted into residual foci under CT guidance. The dosage distribution of radioactive ~(125)I seeds were verified after surgery. The nasopharyngeal endoscopy CT scans were performed at 3, 6, and 12 months after surgery and the short-term efficacy and adverse reaction were evaluated. Results:Out of the 25 patients, 20 patients had complete response (CR), 2 patients had partial response (PR), 2 patients had no change (NC), and 1 patient had progressive diseases (PD). The overall effective rate (CR+PR) was 88.0%. All patients had no serious postoperative complications. Conclusion:CT-guided implantation of radioactive ~(125)I seed was an effective and safe method in the treatment of the residual foci of nasopharyngeal carcinoma after radiotherapy.

Objective To evaluate the anti-tumor activity and toxicity of FOLFIRI regimen in the treatment of patients with advanced colorectal cancer. Methods 22 patients with advanced colorectal cancer used Irinotecan combined with 5-Fu/CF regimen to chemotherapy. Regimen: CPT-11 150 mg/m2 iv drip d1, CF 200 mg/m2 iv drip 2 h d1, 2; 5-Fu 400 mg/m2 iv drip d1, 2; 5-Fu 600 mg/m2 iv drip 22 h d1, 2. It is repeated every 2 weeks, two times a course. Efficiency and toxicity was evaluated after 4-6 cycles. Results Forty four patients were evaluated the efficiency. Two patients achieved CR, 16 PR, response rate was 40.9 %; MST was 11.3 months. TTP was 6.5 months. The main toxicity was cholinergic syndrome and delayed diarrhea,myelosuppression. There were no deaths during treatment. Conclusion The effectiveness of FOLFIRI regimen was higher and side effects was minor in advanced colorectal cancer. It should be further used and studied.

PURPOSE: The purpose of this study was to analyze the current status of Hospital Information system in Yanbian, China. METHODS: Structured self-administered questionnaires were sent to hospitals in Yanbian to survey the issues and six hospitals answered. Data were analyzed by using Windows SPSS 12.0. RESULTS: All facilities were second-grade national hospitals with 100~500 beds, kept about 40 computers and all used internet. Four of them had information exclusive department, and the other two had the implementation plans. All of the hospitals had Patient Billing System and some features of Medication Administration System. Four hospitals had administration systems, and the other two had no plans to develop or adopt administration system in the next three years. Two hospitals used the packages composed of Electronic Data Interchange System, Amount Receivable Management System and Laboratory Information System. One hospital used the Picture Archiving and Communication System, Telemedicine System, Radioactive Examination. CONCLUSIONS: Compared with Korea, the results showed relevant explanation on the delays of implementing HIS and its current status in Yanbian. In order to develop Hospital Information System, various strategies must be developed and active international support and research was required to provide the appropriate experiences.
China* ; Clinical Laboratory Information Systems ; Hospital Information Systems* ; Humans ; Internet ; Korea ; Telemedicine

Objective To assess of feasibility and effectiveness about clinic skill test in the five clinical examination. Methods In our hospital, 23 medical students of 2006 grade seven-year systerm were divided into group A and group B. After clinical practice, the theory test and five clinical examination were completed in both groups, and group A un-derwent clinical skills competition, the results were taken for two independent samples t test, set α=0.05. Group A was taken the practical examination and clinical skills competition, results were taken for two related samples t test, set α=0.05. Results Group A had successful completion in practical assessment and five clinical examination. The results of theory test and five clinical examination had no significant difference in two groups (P>0.05), and clinical skills com-petition results had significantly difference in two groups (P=0.001). In group A, practical assessment and clinical skills competition results had no significantly difference(P>0.05). Conclusion The five clinical examination and practi-cal examination is applicable, which constitute "5+X" pattern. Through the practical examination, can promote the clinic skill of medical students.

Objective To retrospectively analyze and compare the clinical application value of core-needle biopsy (CNB) histology and fine needle aspiration (FNA) cytology in diagnosing malignant thyroid nodules. Methods A total of 134 patients with 137 thyroid nodules (93 malignant nodules and 44 benign nodules) were included in this study. Under ultrasound guidance, successive use of 22 G fine needle and18 G core-needle to puncture each nodule was performed for sampling of thyroid nodule. Surgical findings and pathological manifestations were compared with clinical follow-up results. The success rate of sampling and the diagnostic accuracy, sensitivity as well as specificity for malignant thyroid nodules were compared among FNA, CNB, and CNB/FNA. Results The success rate of puncture sampling with FNA, CNB and FNA/CNB for thyroid nodules was 89.1％, 97.8％ and 100％ respectively. For malignant thyroid nodules, the diagnostic accuracy of FNA, CNB and FNA/CNB was 79.6％, 91.9％ and 96.4％ respectively, the sensitivity was 81.7％, 94.6％ and 97.8％ respectively, and the specificity was 75.0％, 86.4％ and 93.2％ respectively. The success rate of puncture sampling by using CNB or FNA/CNB was significantly higher than that by using FNA (P<0.01), moreover, the diagnostic accuracy and sensitivity for malignant thyroid nodules by using CNB or FNA/CNB was also remarkably higher than those by using FNA (P<0.01) . Conclusion In making diagnosis of malignant thyroid nodules, CNB is accurate, safe and reliable. CNB can be used as a complementary or alternative technique to FNA in clinical practice.