Animals ; Disease Models, Animal ; Ischemic Preconditioning ; methods ; Lung ; blood supply ; Male ; Nitric Oxide Synthase ; metabolism ; Nitroarginine ; pharmacology ; Rabbits ; Reperfusion Injury ; metabolism

Objective To investigate the correlation of intima-media thickness (IMT) of the lower peripheral arteries and maximal shear rate (SR) in diabetic (DM) patients and to analyze the related risk factors.Methods A total of 84 diabetic patients and 46 controls were recruited in the study.Color Doppler ultrasonography technique was applied to observe the IMT,diameter(D) and hemodynamics of the lower peripheral arteries and the comparison with biochemical parameters was carried out in order to reveal their correlation to the pathological changes of vascular in DM patients.ResultsIn DM group,the SR was lower than that in control group (P＜0.05).The risk factors related to the lower peripheral arteries of DM patients also were significant difference to that of control group (P＜0.05).Conclusion The decrease of SR in diabetes patients can cause the thicker IMT,which is one of the important factors leading to atherosclerosis and is correlated to various risk factors for metabolic syndrome.

At present, there are the pheuomena of asking sor maney fram patients, writing out unnecessary prescription,and getting medicaine without payment among physicians. It is mot accord with the humanitarianism for patients imim China As everyone knows, the medical moraiith of health adimin'strative cadre involve that whether of not the quality of health services correspond to need of patients so, in this paper, the author discusses that how to strengthen the medical morality for health adimin's trative cadres.

Objective To investigate the clinical effect of Sodium Hyaluronate Injection and psychological intervention in the treatment of knee osteoarthritis. Methods The control group of patients with knee osteoarthritis treated treatment group in the conventional research on Sodium Hyaluronate Injection, Sodium Hyaluronate Injection treatment combined with psychological intervention, record the two groups before and after treatment of knee joint function changes. Results There was no significant difference between the two groups in the knee function before treatment. After the corresponding treatment, the Lysholm scores of the two groups were significantly higher than before, and the knee joint function improvement in the study group was better (P<0.05). Conclusion The application of sodium hyaluronate and psychological intervention in the treatment of osteoarthritis of knee joint can significantly improve the efficacy of patients, and is conducive to the protection of their physical and mental health, quality of life.

AIM: To establish a method of determining the content of total saponin of Radix et Rhizoma Notoginseng in buccal tablets by HPLC. METHODS: Chromatographic conditions are as follows:Hypersil NH_2 column(4.6 mm?200 mm,5 ?m) as the stationary phase,acetonitrile-1% phosphate buffer solution(0-10 min,20:80;10-20 min,25:75;20-25 min,45:55;25-30 min,50:50) as the mobile phase,the velocity of flow is 1.0 mL/min,the temperature of coloum is 35(?C) and the detection wavelength is 203 nm. RESULTS: The HPLC method has good linearity in determining the total saponin of Radix et Rhizoma Notoginseng content,and we can detect four saponins at the same time,linear range,ginsenoside Rg1 0.093 75-6 ?g,ginsenoside Re 0.011 72-0.75 ?g,notoginsenoside R1 0.023 44-1.5 ?g and ginsenoside Rb1 0.140 6-9 ?g,the correlation coefficient r=0.999 9. CONCLUSION: The established method in this article is simple and convenient,with good reproductivity.We can detect four saponins in the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets at the same time by this method.It can be used for quality control of the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets.

Interventional diagnostic and therapeutic techniques have developed rapidly in recent years with more and more practically and widely utilization as time goes by. The diagnostic procedures consist of percutaneous biopsy, CT discography, pressure measurement of intervertebral disc; and the therapeutic measures include percutaneous periradicular and joint therapy, decompression of sacral cyst, vertebroplasty, kyphoplasty, decompression of intervertebral disc, transarterial chemotherapy and embolization in spinal tumor, and newly developed percutaneous posterior lumbar intervertebral fusion. All above mentioned interventional techniques for spinal column diseases are developing day by day with a promising future and will play an important role in the field of interventional radiologist research.

The chief cause of cancerous pain include six climate exopathogens,internal damage by excess of seven emotions,improper diet and deficiency of vital qi.Accumulation of cancerous toxin,intermingled phlegm and blood stasis and obstruction of meridians are the basic pathogenesis of cancerous pain,among which the accumulation of cancerous toxin is the key point of the pathogenesis,and phlegm and blood stasis are main pathological factors,the both are cause and effect for each other.The deficiency of vital qi is the internal factor of the disease.The location of disease concerns the relative viscera and meridians.The nature of disease is deficiency in the "root" and excess in the "branch" and excess in the "branch" is the main aspect.The therapeutic rules of the disease are removing toxic substance and removing stasis,resolving phlegm to dredge collaterals.And removing cancerous toxin is the crux of the therapy,and resolving phlegm to removing stasis should be applied from the beginning to the end.

Objective:To study the impact of clinical pharmacy information management system on antimicrobial stewardship in a general teaching hospital. Methods:The main function, deficiencies and aspects needing improvement of clinical pharmacy information management system, and its influence on antimicrobial stewardship were introduced. Results:The information system had such functions as antimicrobial usage statistics, evaluation of antimicrobial prescription, and the use intensity calculation of antimicrobials. By using the information system, manpower of antimicrobial stewardship was saved, antimicrobial statistics became more comprehensive and objective, and dynamic real-time monitoring of antimicrobial drugs management was realized. However, the system still had some shortcomings needing improvement. Conclusion:Clinical pharmacy information system can promote the implementation and efficiency of antimicrobial stewardship.

OBJECTIVE To discuss effective methods of nosocomial infection management in disinfection supply division to control the nosocomial infection and improve quality of medical care.METHODS We established the overall arrangement of disinfection supply to strenthen the cleaning,packing and sterilization management for the recycled medical instruments,storage and distribution of the aseptic products,as well as the occupational exposure and protection among the staff in there,to establish the effective nosocomial infection management organization in whole hospital,particularly in disinfection supply division,to study technology of hospital infection,and to enhance the consciousness in control of nosocomial infection.RESULTS The medical safety was improved and nosocomial infection was controlled effectively.CONCLUSIONS The scientific management in disinfection supply division,is the main path way to control nosocomial infection.

Objective To investigate the expression of PTEN and P 27 proteins in esophageal epitheliosis and carcinogenesis , and the relation to the development of esophageal carcinoma .Methods PTEN and P27 proteins ex-pression in 60 fresh tissue specimens , including esophageal mucosa above the upper surgical margin , carcinoma in si-tu and mucosa adjacent to tumor , were detected using immunohistochemical method .Results The expression of e-sophageal epithelial cells PTEN and P 27 proteins in normal , hyperplastic and malignant gradually decreased , which showed a similar distribution pattern in esophageal carcinogenesis .Conclusion Malignant transformation expression change of PTEN and P 27 proteins and esophageal mucosa are closely related , and the expression of PTEN and P 27 proteins deletion may be a biological marker useful and esophageal cancer early diagnosis index .