The chief cause of cancerous pain include six climate exopathogens,internal damage by excess of seven emotions,improper diet and deficiency of vital qi.Accumulation of cancerous toxin,intermingled phlegm and blood stasis and obstruction of meridians are the basic pathogenesis of cancerous pain,among which the accumulation of cancerous toxin is the key point of the pathogenesis,and phlegm and blood stasis are main pathological factors,the both are cause and effect for each other.The deficiency of vital qi is the internal factor of the disease.The location of disease concerns the relative viscera and meridians.The nature of disease is deficiency in the "root" and excess in the "branch" and excess in the "branch" is the main aspect.The therapeutic rules of the disease are removing toxic substance and removing stasis,resolving phlegm to dredge collaterals.And removing cancerous toxin is the crux of the therapy,and resolving phlegm to removing stasis should be applied from the beginning to the end.

Objective: To prepare injectable interferon α-2b(IFN-α-2b) loaded microsphere and develop a long-acting dosage form. Methods: IFN-α-2b loaded microspheres were prepared with poly(lactic-co-glycolic acid) (PLGA) as carrier material by double emulsion(w/o/w) method and solid in oil in oil(s/o/o) method separately. Physical and chemical characteristics of microspheres (mean diameter, morphology and drug entrapment efficiency) were evaluated; the in vitro release behavior and influencing factors of the microspheres were determined by micro-BCA(bicinchoninic acid) method; and IFN-α-2b stability during encapsulation and in vitro release was evaluated by sodium dodecyl sulfate polyacrylamide gel electropheresis. Results: The 2 types of microspheres produced had good shape and dispersive quality and a drug entrapment efficiency of more than 80%. IFN-α-2b bulk ultrafitration can significantly influence the mean diameter and in vitro release behavior of microspheres prepared by w/o/w method. The accumulated release(within 1 month) of the microspheres prepared by both methods was significantly improved when using PLGA with lower inherent viscosity. SDS-PAGE test showed aggregation of IFN-α-2b with s/o/o method, while there was no difference between the electrophoretic behavior of bulk IFN-α-2b and IFN-α-2b in microspheres prepared by w/o/w method. Conclusion: IFN-α-2b can be encapsulated into injectable microspheres to yield a one-month continuous release by both w/o/w method and s/o/o method.

Objective To improve the health of women and children,we built a medical research platform with maternal and child health characteristics and feature.Methods Since January 2011,we build the medical research platform of Huaian MCH through the following three aspects.①To firmly establish the thought of Science and technology to revitalizing the hospital and outstand technical innovation.② built a medical research platform with maternal and child health characteristics and feature.③To focus on construction of Research platform.Results After building research platform,the total number of published papers or high-level papers and the total number or level of the Research Projects and the New Technology Award are significantly higher.Many disciplines and specialist technical levels have been improved in our MCH.Neonatal Medical Center and Children's Health Center have upgraded to Provincial Maternal and Child Healthcare key disciplines.The department of women healthcare has upgraded to Provincial Maternal and Child Healthcare key disciplines construction unit.In 2012,our MCH got top 30 of comprehensive index ranking in operation and development of the National Maternal and Child Health agencies.Conclusion Building the medical research platform with the characteristics of maternal and child healthcare,can improve maternal and child healthcare service quality and level of clinical services,and promote the development of the hospital's overall strength,thereby increasing the ability of hospitals to protect the health of women and children.

Objective To establish a diagnostic scoring system for diabetic patients with smear-negative pulmonary tuberculosis , and then to improve the rapidity and accuracy of clinical diagnosis and save medical expenses. Methods A case-control study was applied. 150 diabetic patients with smear-positive pulmonary tuberculosis who on initial treatment were assigned to a study group; 150 patients with lung infection were recruited as a study group. The data on general status, symptoms, chest X-ray manifestation, and laboratory examinations was collected. Univariate logistic regression analysis was used to gain significant indexes for multiple logistic regression analysis. β-coefficients derived from the independent predictors in our logistic regression model was applied to develop a scoring system. Results Toxic symptoms of tuberculosis, cough, upper lung, cavity, multiple lung field , and PPD positive entered into the final multipie logistic regression model , and the scoring system was accordingly established. The patient with a score of more than 11 had higher probability of TB , while those with a score of smaller than 11 were not likely to have TB. Conclusion The scoring system can be used as a predictive tool in diagnosis of diabetes mellitus complicated by smear-negative pulmonary tuberculosis , helping diagnose active tuberculosis rapidly.

[Objective] Probe the source of Nv’ke Baixiao Quanshu or Obstetrics and Gynecology Pandect compiled by Gong Juzhong in Ming Dynasty, explorate the content and academic idea. [Methods]Through investigating and surveying the different editions, col ating and organizing the contents, probe and analyse the writing motivation, content and main idea of the work. [Results] The most contents of Nu ’ke Baixiao Quanshu are inherited from an-other work named Jiaozhu Furen Liangfang with 8 contents:Regulating the menstrual period, praying for children, antenatal training, previous preparation for delivery, parturition, lying-in, difficult labouring. The rest of the contents is extracted from some other works. This work records disease symptoms and medicine, surgery, gynecology and gravidity in various internal organs. Referring ancient classics on disease causes and researching prescriptions and treatments, the author emphasized naturalizing liver, kidney and spleen in warm. Mr. Gong applied drugs corresponding to syndromes. In the Qiusi and Taihou parts, he discussed rationales of infertility, natural endowment and pre-natal and post-natal care and introduced methodology of pulse feeling to diagnose pregnancy, Yuanfang Chao’s twelve col ateral channels in nourishing and training fetus, medicine conditioning for pregnant women, daily regi-men, medicine prohibition, preparation of ante partum. [Conclusion] Nu ’ke Baixiao Quanshu is created by extracting. Mr gong learned widely from oth-er’s strong points and compiled with distinct academic view, significantly guiding development of clinical medicine in department of gynecology of tradi-tional Chinese medical science and formation of system of reproduction care. Yet, some theories like methodologies of gender-oriented reproduction and gender-shifting reproduction should be discarded.

Objective To explore the effect of aspirin resistance on cardiovascular events in non-insulin-dependent diabetes melli-tus patients .Methods 496 patients with non-insulin-dependent diabetes mellitus received daily aspirin therapy (100mg/d) 4 weeks were recruited from Jun .2006 to Sept .2010 .Platelet aggregation was measured by light transmission aggregometry .The patients were divided into three groups :aspirin resistance group ,aspirin semi-resistance group and aspirin-sensitive group .The clinical bio-chemistry indications and the adverse cardiovascular events were collected .Results 11 .69% of patients were found to be resistant to aspirin therapy ,and 37 .90% of patients to be aspirin semi-responders .There were 67 .48% female in aspirin resistance group and aspirin semi-responders .The preprandial glucose of group AR and ASR was higher than that of group AS (P<0 .05) .The HbA1C and TG of group AR were higher than those of group AS(P<0 .05) .There was statistically significant difference of the rate of car-diovascular events .Conclusion The measure of platelet aggregation should be taken in the diabetic mellitus patients and pay atten-tion on the dose of aspirin recommended .Particular attention is should also devote to the incidence of adverse cardiovascular events .

Interventional diagnostic and therapeutic techniques have developed rapidly in recent years with more and more practically and widely utilization as time goes by. The diagnostic procedures consist of percutaneous biopsy, CT discography, pressure measurement of intervertebral disc; and the therapeutic measures include percutaneous periradicular and joint therapy, decompression of sacral cyst, vertebroplasty, kyphoplasty, decompression of intervertebral disc, transarterial chemotherapy and embolization in spinal tumor, and newly developed percutaneous posterior lumbar intervertebral fusion. All above mentioned interventional techniques for spinal column diseases are developing day by day with a promising future and will play an important role in the field of interventional radiologist research.

Objective To investigate the clinical effect of Sodium Hyaluronate Injection and psychological intervention in the treatment of knee osteoarthritis. Methods The control group of patients with knee osteoarthritis treated treatment group in the conventional research on Sodium Hyaluronate Injection, Sodium Hyaluronate Injection treatment combined with psychological intervention, record the two groups before and after treatment of knee joint function changes. Results There was no significant difference between the two groups in the knee function before treatment. After the corresponding treatment, the Lysholm scores of the two groups were significantly higher than before, and the knee joint function improvement in the study group was better (P<0.05). Conclusion The application of sodium hyaluronate and psychological intervention in the treatment of osteoarthritis of knee joint can significantly improve the efficacy of patients, and is conducive to the protection of their physical and mental health, quality of life.

OBJECTIVE To discuss effective methods of nosocomial infection management in disinfection supply division to control the nosocomial infection and improve quality of medical care.METHODS We established the overall arrangement of disinfection supply to strenthen the cleaning,packing and sterilization management for the recycled medical instruments,storage and distribution of the aseptic products,as well as the occupational exposure and protection among the staff in there,to establish the effective nosocomial infection management organization in whole hospital,particularly in disinfection supply division,to study technology of hospital infection,and to enhance the consciousness in control of nosocomial infection.RESULTS The medical safety was improved and nosocomial infection was controlled effectively.CONCLUSIONS The scientific management in disinfection supply division,is the main path way to control nosocomial infection.

To elucidate the academic thought of Professor ZHOU Zhong-ying about cancerous toxin. Professor Zhou holds that the cancerous toxin,a toxic pathogen occurring during the occurrence and development of malignant tumor,is the key for occurrence of malignant tumor. The compound pathogeneses of malignant tumor are the coexistence,reciprocal causation,combination and transformation between the cancerous toxin and the pathological factors of phlegm,blood stasis and dampness. Based on the theory of cancerous toxin,the therapeutic rules of malignant tumor should be removing carcinoma and eliminating toxin,supporting vital qi to eliminate pathogens,and combined the resolving phlegm,removing blood stasis,eliminating dampness or clearing away heat according to the different pathological factor accompanying,such as phlegm,blood stasis or dampness,etc.