ObjectiveThe purpose of this study was to investigate the effect of health education on the recovery of insight in schizophrenic patients. MethodThe insight of patients in health education and control groups was assessed by SAUMD and BPRS bdfore and 4, 8, 12 weeksafter trentment. ResultThe recovery of insight of health education group was significantly different from control group after treatment. Theinsight scores was significantly related to major symptom, cultural level and disease course. ConclusionThe health education for schizoprenicpatients was important in recovering insight and illness and promoting patients go back to society early.

Objective To explore the relationship between subclinical hypothyroidism(SCH)and microvascular complications(diabetic nephrop-athy and diabetic retinopathy)in type 2 diabetic patients. Methods According to the condition of complicating with SCH,157 patients with type 2 diabetes were divided into SCH group(40 cases)and the euthyroid group(117 cases). The age,sex,duration of diabetes,smoking status,blood pressure,body mass index(BMI),glycosylated hemoglobin(HbA1c),blood lipid,renal function,thyroid function,urine albumin/urine creatinine, and fundus examination were analyzed and compared between the two groups. The relationship between SCH and microvascular complications in type 2 diabetic patients was explored. Results There was no significant difference of age,sex,duration of diabetes,smoking,blood pressure,BMI, HbA1c,blood lipid,or serum creatinine between the two groups. The incidence of diabetic retinopathy in SCH group was significantly higher than those in euthyriod group(32.5%vs 14.5%,P=0.044);however there was no difference in the incidence of diabetic nephropathy. After adjustment for potential confounding factors(age,sex,duration,blood pressure,BMI,HbA1c,diabetic nephropathy)by multivariate logistic regression analy-sis,SCH was still the risk factor of diabetic retinopathy(OR=2.210,95%CI 1.512-4.117,P=0.032)in type 2 diabetic patients. Conclusion SCH could be a risk factor of diabetic retinopathy in type 2 diabetic patients,and there was no significant effect on diabetic nephropathy.

Objective To investigate the applicative effect of cardiopulmonary resuscitation in pre-hospital care of emergency pa-tients with cardiac arrest and provide the basis for pre-hospital care of cardiac arrest.Methods Selected 93 cases of cardiac arrest in January 2011 to May 2013 occurred out of Hainan Province Nongken Sanya Hospital,including 51 cases of cardiopulmonary resusci-tation of pre hospital rescue as the study group,42 cases of the application of artificial compression cardiopulmonary resuscitation as control group.Compared blood oxygen saturation,oxygen and carbon dioxide partial pressure and blood pressure changes,CPR time,spontaneous breathing recovery time and the recovery of the function of two groups.Used chemiluminescence method to detect NSE,NT-proBNP,cTnI and H-FABP.Results The two groups of patients with blood oxygen saturation,oxygen and carbon diox-ide partial pressure showed no statistical difference(P>0.05);the DBP and SBP levels of the study group were significantly higher than the control group(P<0.05);the study group CPR time and spontaneous circulationtime were significantly higher than that in control group(P<0.05).Two groups of intraoperative heart rate,respiration,blood pressure and oxygen saturation had no signifi-cant difference(P>0.05).Study group of patients with spontaneous breathing recovery,the restoration of spontaneous circulation, survival is greater than 24 h and rehabilitation discharge rates were significantly higher than the control group(P<0.05).There was no significant difference in the serum levels of NSE,NT-proBNP,cTnI immediately,H-FABP recovery in spontaneous circula-tion(P>0.05);after 24 h,NSE,NT-proBNP,cTnI,H-FABP levels in study group were significantly lower than those in the control group(P<0.01).Conclusion The application of cardiopulmonary resuscitation in patients with cardiac arrest before salvage can ef-fectively shorten the recovery time of CPR patients and spontaneous circulation time,reduce the damage to heart,brain,lung and other organs,improve the success rate of cardiopulmonary resuscitation,worthy of clinical application.

Two-component signal transduction system (TCS) exists extensively in prokaryotic cell ,which plays a key role of regulation in the growth ,differentiation ,metabolism ,virulence ,persistence ,and pathogenicity .PhoPR two-component signal transduction system ,as one of two-component systems ,is the most basic and the most importantly sensitive to the envi-ronmental changes and makes corresponding certain reaction system adapt to changes in the host microenvironment .Therefore , PhoPR TCS which is an important regulatory system of Mycobacterium tuberculosis (MTB) to adapt to environmental change has been increasing concern ,even PhoPR TCS is becoming the new front-burner issue in the pathogenesis of M TB regulation of research .

The ocean is the treasure house by which human being live. The variety and particularity of marine creature provide people many physiological active substances, which are novel and unique in structure and effect. The recent research of marine active antitumor proteins and peptides was summarized in this article.

During cell apoptosis,a series of characteristic changes occur in the cell configuration and,according to recent findings,in the cytoskeleton as well,including degradation,condensing and maldistribution of the cytoskeleton reticular formation.Through investigations of the biological activity and function of the cytoskeleton protein,the dynamic changes of the cytoskeleton during cell apoptosis and related regulatory factors,we found that the change of configuration is based on that of the cytoskeleton during cell apoptosis,which suggests that we can achieve the purpose of curing tumors and other diseases by inducing cell apoptosis through changing the cytoskeleton configuration.

The core event of cell proliferation is DNA replication and cell division. DNA topoisomerase type Ⅱ plays an important role in this process.As a cell proliferating marker,DNA topoisomerase type Ⅱis caught great attention. The authors review the recent research of NDA topoisomerase type Ⅱ and its value evaluated as a cell proliferating marker.

Objective To study the clinical effect of Xianglian in Mixture (Mixture of Nutgrass Galingale Rhizome and Golden Thread) in treatment of premature beat accompanied anxiety disorder.Methods Totally 100 patients of premature beat accompanied anxiety disorder were randomly assigned into two groups.The 50 patients in the treatment group were treated with Xianglian Mixture and the 50 in the control group were treated with Rytmonorm and Alprazolam for 4 weeks.The TCM symptom scores,premature beats in Holter,scores of Hamilton anxiety scale (HAMA) and the therapeutic effect on all these indices of both groups were observed.Results After treatment,the TCM symptom scores,premature beats in Holter,scores of HAMA of both groups were decreased significantly (P0.05).Conclusion Xianglian Mixture can reduce premature beats and relieve anxiety as well.

Human promyelocytic leukemia HL - 60 cells labelled with 3H - inositol were treated with vincristine (VCR), it was found that the radioactivity of 3H-phosphatidyl inositol - 4-phosphate (PIP) and 3H - Phosphatidyli-nositol - 4,5 - bisphosphate(PIP2) had no obvious change, but that of 3H-phosphatidyl inositol (PI) decreased rapidly, only accounted for 38. 55%~61.01% of the control during 1~ 120 min of the treatment. It showed that VCRdid not affect the activity of PI kinase and PIP kinase, but enhanced the hydrolysis of PI of HL - 60 cells. The inhibitorty effect of VCR upon cell proliferation and DNA synthesis was observed after above biochemical changes,these results suggest that VCR may inhibit HL-60 cells proliferation by interfering the metabolism of phosphoininositides.