Wound biotherapy, represented by platelet concentrate derivatives, has attracted much attention. However, there are some different viewpoints due to the disunity of quality control of preparation, the ways of use, and so on. The members of the consensus writing group reviewed a large number of literatures, screened out high-quality evidence references, combined with the repeated discussion of experts in the field of wound repair to form a guiding consensus of experts, so as to guide medical personnel using enriched platelet treatment scientifically and standardly in wound repair.
Blood Platelets/physiology* ; Consensus ; Humans ; Wound Healing/physiology*

Chronic wounds pose a clinical challenge. Such wounds may present all over the body although the majority appear on the lower extremities. In the main, wounds are caused by hypertension (venous or arterial), diabetes, although infection, trauma, and animal bites can result in non-healing wounds. It is vital to have a reliable diagnosis in order to plan treatment. Despite advances in diagnostics and the development of standard care packages, chronic wounds present a growing burden to all societies. One of the problems faced is the poor understanding of the pathophysiology of wounds; it is commonly accepted that microcirculation is impaired in lower extremity chronic wounds. This paper is focused on the significance and assessment of impaired microcirculation.
Diabetic Foot ; pathology ; Humans ; Microcirculation ; Wound Healing ; physiology

Animals ; Homeodomain Proteins ; metabolism ; Humans ; Skin ; metabolism ; Wound Healing ; physiology

After healing of burn wound, skin of scar, transplanted skin grafts, and healed donor site wound suffer from temporary or permanent loss of function of sebaceous glands and dysfunction of skin surface lipid film formation, resulting in desiccation, desquamation, and sensitiveness of the skin, making areas of newly formed skin unsatisfactory. Therefore a good rehabilitation may fail. In this paper, the composition, physiochemical properties, and reconstruction of skin surface lipid film are discussed.
Cicatrix ; Lipids ; physiology ; Skin ; pathology ; Skin Transplantation ; Wound Healing

As a result of the stimulation of proinflammatory mediators, circulating peripheral-blood mononuclear cells migrate into the wound area, and they differentiate into different phenotypes of macrophage to take different roles in healing process. Their phenotypes interchange under different microenvironments. The disturbance of cutaneous environment in diabetic patients has been shown to alter the quantity, morphology, and functions of the macrophages resulting in retardation of wound healing. Healing of intractable diabetic wound can be improved by the supplement of exogenous growth factors, which might improve healing process by regulating the phenotype of macrophage in intractable diabetic wound. This article reviews the relationship between intractable diabetic wound and macrophage to explore new methods of treating intractable diabetic wound.
Diabetes Mellitus ; immunology ; metabolism ; Humans ; Macrophages ; physiology ; Skin ; Wound Healing

At present, current stimulation, ultra-sound, and light therapy have become effective methods to promote wound healing. Among them, infrared light is the most widely used method and is one of the important methods to promote wound healing. The therapeutic effect of infrared light on wounds is related to the effect of photobiomodulation on cells and molecules on the skin surface, but the mechanism by which photobiomodulation of infrared light promotes wound healing has not been fully elucidated. Therefore, it is necessary to study the action characteristics and the mechanism of photo-biomodulation of infrared light in promoting wound healing. This article reviews the effect of different types of infrared light on wound healing and the mechanism of infrared light in promoting wound healing.
Infrared Rays ; Low-Level Light Therapy/methods* ; Wound Healing/physiology*

Ubiquitin, a critical small molecular protein, plays an important role in regulating multiple signaling pathways. Ubiquitination is a post-translational modification induced by ubiquitin through an ATP-dependent enzyme catalyzed reaction. A large number of proteins in the complicated signaling network participate in wound healing. This paper reviews the research progress in regulation of ubiquitin and ubiquitination for wound healing processes regarding the recent years.
Signal Transduction ; physiology ; Ubiquitin ; metabolism ; Ubiquitin-Protein Ligases ; physiology ; Ubiquitination ; Wound Healing ; physiology

Amnion ; metabolism ; physiology ; Female ; Hepatectomy ; Humans ; Liver Regeneration ; physiology ; Pregnancy ; Wound Healing ; physiology

Fetal wound healing has drawn the attention of many researchers from diverse background and specialties. Fetal wound healing is unique and differs from postnatal healing in that fetal skin wounds heal rapidly without scar formation. If the mechanism underlying such phenomenon can be elucidated, it will be serve as a significant milestone in the study of wound healing. Furthermore, the implications for therapeutic applications in wound management and in diseases where scarring is the basic pathogenetic mechanism would be immense. Rather than to list the results and conflicting data of numerous studies, this article hopes to provide a general overview of the recent developments.
Animal ; Cell Adhesion Molecules/physiology ; Collagen/physiology ; Extracellular Matrix/physiology ; Fetus/*physiology ; Growth Substances/physiology ; Human ; *Wound Healing

Cutaneous wounding in adult humans and higher vertebrate animals results in scar formation. In contrast, both human and animal fetuses, at early gestational ages, exhibit skin wound healing without scarring. This distinction suggests that the repair of adult wounds by skin regeneration, rather than by fibrosis, may be achieved if adult wounds can be modified to mimic the healing process of fetal wounds. The development of gene therapy offers the possibility to specifically enhance or block the gene expression of cytokines and extracellular molecules, and thus convert adult wound healing into a healing process more similar to tissue regeneration. This article reviews the characteristics of fetal wound repair focusing on cytokine profiles and the inflammatory response to dermal injury. Also included are new developments in gene transfer techniques as well as their application in wound healing. Finally, the authors propose possible strategies of wound gene therapy, to reduce wound scarring and to promote tissue regeneration.
Animal ; Cicatrix/*prevention & control ; Fetus/physiology ; *Gene Therapy ; Human ; Wound Healing/physiology