1.Pathogenesis of Myocardial Infarction in Clinical Perspective.
Korean Circulation Journal 1992;22(1):3-6
No abstract available.
Myocardial Infarction*
2.A Case of Romano-Ward Syndrome.
Korean Circulation Journal 1982;12(2):239-243
Since Romano(1963) described Romano-Ward syndrome which is characterized by Q-T prolongation, abnormal T wave, ventricular tachcardia and syncopal attacks, about twenty cases have been reported in various countries of the world, but this case represents the first report of this syndrome in Korea. Authous experienced a case of Romano-Ward syndrome in a 23-year-old man who had been suffering from intermittent paroxysmal palpitation, chest discomfort and dyspnea for 11 years. On admission, he had tachycardia, gallop and engorgement of jugular veins. EKG showed ventricular tachycardia which promptly recurred after repeated attempts of cardioversion. Then, procainamide and digoxin were given. One day later, sinus bradycardia with Q-T prolongation with Deep T wave inversion occured. Therefore, propranol was prescribed under the impression of Romano-Ward syndrome. About 4 months later, EKG was normal except for mild Q-T prolongation and he was able to maintain normal life activity without difficulty.
Bradycardia
;
Digoxin
;
Dyspnea
;
Electric Countershock
;
Electrocardiography
;
Humans
;
Jugular Veins
;
Korea
;
Procainamide
;
Romano-Ward Syndrome*
;
Tachycardia
;
Tachycardia, Ventricular
;
Thorax
;
Young Adult
3.The Effect of Oral Mexiletine on Chronic Ventricular Premature Beats: Evaluation by a Double-Blind Cross-Over Protocol.
Korean Circulation Journal 1983;13(1):83-90
The effect of oral mexiletin was evaluated by a 10-day double-blind cross-over protocol on 10 subjects with chronic stable high-frequency ventricular premature beats referred to our cardiology clinic from February through July, 1982. Total daily doses were either 450mg or 600mg in three divided portions depending on body weight. The frequency of the premature ventricular beats was measured by 3 separate 24-hour ambulatory EKG recordings by dual-channel Holter monitor on each patient. Mexiletine was judged to be effective in suppressing the ventricular arrhythmias when the 24-hour PVC-counts during the study-drug period showed a decrease by 80% and the hourly average PVC-counts by 70% compared with those of the equivalent intervals of both the baseline and the placebo periods. Mexiletine was effective in 5 of the 10 subjects. Mild tremor and anorexia were noted in 2 patients, but they were able to comply with the study protocol in spite of these minor side effects. Blood level measurements were not done in this study for lack of such facility, the utilization of which would undoubtedly enhance the therapeutic effectiveness of the antiarrhythmic agent in the individualization of treatment.
Anorexia
;
Arrhythmias, Cardiac
;
Body Weight
;
Cardiac Complexes, Premature*
;
Cardiology
;
Electrocardiography
;
Humans
;
Mexiletine*
;
Tremor
;
Ventricular Premature Complexes
4.The Effect of Oral Mexiletine on Ventricular Arrhythmias Evaluation by Holter Monitoring.
Korean Circulation Journal 1985;15(3):441-446
The antiarrhythmic effect of oral Mexiletine was evaluated by Holter monitoring on 10 subjects with chronic high-frequency ventricular premature complexes and ventricular tachycardia referred to our cardiology clinic of Severance Hospital from June, 1982 through September, 1983. The frequency of the ventricular premature complexes and the ventricular tachycardia was measured by 24-hour ambulatory electrocardiography on each patient before and during the administration of Mexiletine(450-600 mg/day). The results were as follows : 1) In 10 patients with ventricular tachycardia total suppression of ventricular tachycardial was demonstrated in 8 patients during the administration of oral Mexilletine. 2) The number of the ventricular premature complexes was reduced markedly in 6 out of the 10 patients. 3) Side effects occurred in 5 out of 10 patients. These include tremor, weakness, dry mouth, indigestion, anorexia, chest discomfort, and dizziness but were tolerated except in one.
Anorexia
;
Arrhythmias, Cardiac*
;
Cardiology
;
Dizziness
;
Dyspepsia
;
Electrocardiography, Ambulatory*
;
Humans
;
Mexiletine*
;
Mouth
;
Tachycardia, Ventricular
;
Thorax
;
Tremor
;
Ventricular Premature Complexes
5.A Study on Intraventricular Conduction Disturbances in Electrocardiogram.
Woong Ku LEE ; Won Heum SHIM ; Hong Do CHA
Korean Circulation Journal 1973;3(2):1-18
The electrocardiograms of a total of 12,796 patients taken in the past three years at Severance Hospital were reviewed for conduction disturbances which were found in 314 cases(2.46%). Th first degree atrioventricular block occurred in 65 cases, and second degree atrioventricular block with Wenckebach periodicity in 13. There were 9 cases of third degree atrioventricular block with nomal QRS complexes causing Adams-Stokes attacks which represented 2.9% of all conduction disturbances. It occurred equally in both sexes and predominantly after 6th decade of life. There were 99 cases of complete right bundle branch block(RBBB) and 12 cases of complete left bundle branch block(LBBB). The latter were mainly associated with significant heart diseases. As for the intraventricular conduction defects other than the simple bundle branch blocks, the findings were as follows; 1. Simple hemiblocks were found in 92 cases or 0.73% of total series and 29.3% of all conduction disturbances. Left anterior hemiblock(LAH) occurred 3 times more frequently than left posterior hemiblock(LPH). 2. Partial bilateral bundle branch block(BBBB) were found in 25 cases representing 0.2% of the total series and 8.0% of all conduction disturbances. Among the 25 cases of BBB, 11 had RBBB plus LAH, 10 RBBB plus LPH, 1 LBBB plus first degree A-V block, and 3 LBBB of diphtheritic cardic involvement. Trifascicular heart block causing Adams-Stokes attacks occurred in 9 of the 25 cases resulting in death in 7 cases. The underlying diseases were ischemic heart disease, hypertensive heart disease, congenital heart disease and diphtheritic carditis. This report represents the first electrocardiographical documentation of occurrence of trifascicular heart block progressing from BBBB in Korea.
Atrioventricular Block
;
Bundle-Branch Block
;
Electrocardiography*
;
Heart Block
;
Heart Defects, Congenital
;
Heart Diseases
;
Humans
;
Korea
;
Myocardial Ischemia
;
Myocarditis
;
Periodicity
6.Retrograde Conduction in Complete Heart Block.
Young Hak SHIM ; Woong Ku LEE ; Hong Do CHA
Korean Circulation Journal 1972;2(2):53-55
A 45 year old man with a history of syncopal attacks of 3 days' duration showed complete heart block with occasional retrograde P waves following QRS complexes in the electrocardiogram. The site of A-V block seemed to be below A-V node judging from the QRS complexes when occasional capture occured. This may be a case of complete heart block progressing from right bundle branch block plus left posterior hemiblock. There was a rapid improvement of conduction with sublingual isoproterenol in a few days, EKG's showing normal A-V conduction and QRS complexes on discharge. The mechanism of the retrograde conduction in the presence of complete heart block is discussed with a review of literature.
Atrioventricular Node
;
Bundle-Branch Block
;
Electrocardiography
;
Heart Block*
;
Heart*
;
Humans
;
Isoproterenol
;
Middle Aged
7.Familial Study of Hypertrophic Cardiomyopathy.
Moon Jae KIM ; Hak Yrul KIM ; Woong Ku LEE
Korean Circulation Journal 1984;14(2):385-392
Hypertrophic cardiomyopathy has been a well-known genetical transmitted disease entity with the advance of echocardiography. We have recently experienced a family with hypertrophic cardiomyopathy proved by noninvasive methods including chest x-ray,, electrocardiography and echocardiography. The propositus of this family was a 21 year-old solier who was admitted because of exertional dyspnea during military exercise. Both he and his sister had severely affected hearts with typical echocardiographic findings, asymmetrical septal hypertrophy(ASH) and systolic anterior motion of the anterior mitral leaflet(SAM). The clinical study is reported with the concerned literatures.
Cardiomyopathy, Hypertrophic*
;
Dyspnea
;
Echocardiography
;
Electrocardiography
;
Heart
;
Humans
;
Military Personnel
;
Siblings
;
Thorax
;
Young Adult
8.Percutaneous Transluminal Angioplasty of a Stenosis of an Internal Mammary Artery Graft.
Seung Jung PARK ; Woong Ku LEE ; Seung Jae TAHK ; Seung Yun CHO ; Won Heum SHIN
Korean Circulation Journal 1988;18(4):709-712
Successful percutaneous transluminal angioplasty (PTA) of an internal mammary artery graft was performed in a 40 year old male patient who had recurrent angina soon after bypass surgery. Coronary angiography showed total occlusion of proximal portion of the left anterior descending artery and normal right coronary artery. Angiography of the left internal mammary artery graft revealed a tight stenosis (90% diameter narrowing) in the mammary artery at its insection into the left anterior descending artery.Angiography after the angioplasty demonstrated a widely patent graft (residual stenosis 10%) and translesional pressure gradient was 10 mmHg.
Adult
;
Angiography
;
Angioplasty*
;
Arteries
;
Constriction, Pathologic*
;
Coronary Angiography
;
Coronary Vessels
;
Humans
;
Insects
;
Male
;
Mammary Arteries*
;
Transplants*
9.A Case of Congenital Arteriovenous Fistula at Left Subclavian Artery Accompanied by Notching on Superior Aspect of Rib.
Ick Mo CHUNG ; Seung Yun CHO ; Seung Jung PARK ; Woong Ku LEE ; Jin Suk SEO
Korean Circulation Journal 1989;19(1):139-145
High output heart failure due to congenital arteriovenous fistula is a rare disease and is difficult to treat. A 27 year old man, suffering from dyspnea, palpitation, lower extremity edema, and abdominal distension admitted May, 1987. At admission there were continuous thrill and bruit at left supraclavicular and infraclavicular area. The heart sound was irregular and rapid, and grade IV/VI pansystolic murmur was audible at the apex. Chest PA showed marked cardiomegaly with pleural effusion and notching at superior aspect of left 2nd rib. Selective left subclavian artery angiogram showed extensive congenital arteriovenous fistula at the area of left subclavian artery and its branches. After setrial feeding artery embolization and palliative operation, the fistula size decreased much with clinical improvement.
Adult
;
Arteries
;
Arteriovenous Fistula*
;
Cardiomegaly
;
Dyspnea
;
Edema
;
Fistula
;
Heart Failure
;
Heart Sounds
;
Humans
;
Lower Extremity
;
Pleural Effusion
;
Rare Diseases
;
Ribs*
;
Subclavian Artery*
;
Thorax
10.Effect of COENZYME Q10(Decaquinon) in Congestive Heart Failure.
Woong Ku LEE ; Jae Bock CHUNG ; Won Heum SHIM ; Seung Yun CHO
Korean Circulation Journal 1979;9(2):109-114
From May, 1978 through Oct., 1979 the effect of Coenzyme Q10 was evaluated on 10 patients with chronic heart failure. The subjects selected for this study consisted of 7 patients with cardiomyopathy and 3 patients with valvular heart disease admitted to Severance Hospital, Yonsei University College of Medicine, All these patients had symptoms and signs of congestive heart failure which was stable for at least one month before starting Coenzyme Q10. Coenzyme Q10 was administered 30mg daily for eight weeks, one hour before meal and in combination with digitalis and/or diuretics. The drug effects were determined by measuring the cardio-thoracic ratio by chest X-ray, the sum of 'S' wave in V1 and 'R' wave in V5 in electrocardiogram, and PEP/LVET (pre-ejection period/left ventricular ejection time) by simultaneous tracings of carotid pulse and phonocardiogram every two weeks during medication. The cardio-thoracic ratio was improved in 4 of 10 cases, the sum of RV+SV5 was decreased in all 5 cases who showed voltages above 40mm before medication, and PEP/LVET ratio was decresed in 4 of 10 cases. The difference of average values before and after medication were not statistically significant(p<0.05) in all 3 parameters when examined by t-test. During treatment, there was improvement, if any, from two weeks after medication and no significant side effects were noted throughout the study period.
Cardiomyopathies
;
Digitalis
;
Diuretics
;
Electrocardiography
;
Estrogens, Conjugated (USP)*
;
Heart Failure*
;
Heart Valve Diseases
;
Humans
;
Meals
;
Thorax