1.A Case of Congenital Long OT Syndrome with Pseudo - Atrioventricular Block.
Kyoung Hi JEON ; Yong Woon BACK ; Hyun Kee CHUNG ; Tae Jun CHA ; Sung Rae CHO
Journal of the Korean Society of Neonatology 1999;6(2):263-267
The congenital long-QT syndrome (LQTS) is characterized by recurrent syncope, prolonged QT intervals, QT interval lability, polymorphic ventricular tachycardia, and sudden death. We report a case of congenital long QT syndrome in a 28-day-old male infant who presented with syncope, bradycardia with 2: 1 pseudo-atrioventricular block and a markedly prolonged QT inteval. One episode occured after crying and degenerated into ventricular fibrillation and terminated after cardioversion. A VVI type cardiac pacemaker was implanted. Subsequently, the infant's heart rate was over 110/min and 2: 1 AV block and any other arrhythmia were absent. The infant recovered from the accompanied pneumonia and sepsis and was discharged 47 days after adrnission. However, 13 days after discharge, the infant returned to our hospital ER with syncope. Ventricular fibrillation ceased after cardioversion. Despite medication with propranolol, ventricular tachycardia persisted. The infant expired the day after he was discharged against medical advice.
Arrhythmias, Cardiac
;
Atrioventricular Block*
;
Bradycardia
;
Crying
;
Death, Sudden
;
Electric Countershock
;
Heart Rate
;
Hospitals
;
Humans
;
Infant
;
Long QT Syndrome
;
Male
;
Pneumonia
;
Propranolol
;
Sepsis
;
Syncope
;
Tachycardia, Ventricular
;
Ventricular Fibrillation
2.Antibody to Hepatitis A Antigen in Children and Adolescents in Korea.
Journal of the Korean Pediatric Society 1982;25(1):36-40
Antibody to hepatitis A antigen was detected, by radiommuncassay, in sera froom 455 hospitalized children and adolescents without a liver disease or a clinically recognizable hepatitis history. The positive rate of antibody was over 90% in newborn infants and then progressively decreased and reached its lowest level, 9.1%, at age 7-12 months. The high positive rate in newborn infants is suggested to be a result of transplacental passive immunity, which seems to nearly disappear by the age of 7 months. The positive rate gradually increased throughout childhood: 3% at age 4-6 years, 51.1% at 7-9 years, 83.0% at age 13-15 years and 93.1% at age 16-19 years. This finding indicate that hepatitis A had developed in about one half of children until the age of 10 years and in nearly all until the age of 19 years. The prevalence of antibody was independent of sex, socioeconomic status and resident area and did not correlate significantly with serologic evidence of hepatitis B virus infection.
Adolescent*
;
Child*
;
Child, Hospitalized
;
Hepatitis A*
;
Hepatitis B virus
;
Hepatitis*
;
Humans
;
Infant, Newborn
;
Korea*
;
Liver Diseases
;
Prevalence
;
Social Class
3.A Case of Neonatal Lupus Syndrome with Congenital Heart Block.
Tae Guen CHU ; Yong Woon BACK ; Jae Won HUH ; Chang Youn LEE ; Hyun Kee CHUNG ; Jae Sun PARK
Journal of the Korean Society of Neonatology 1997;4(2):260-266
Neonatal lupus erythematous is a rare syndrome, which is characterized by a transient lupus dermatitis, hematologic abnormalities and isolated congenital heart block. We detected the atrioventricular dissociation, bradycardia and pericardial effusion by fetal echocardiography in a female fetus at 25th weeks of gestational age. The baby was born in the 38th week of pregnancy by Cesarean section with 1790 gram of body weight. In spite of atrioventricular dissociation with bradycardia and pericardial effusion, cardiac pacemaker was not needed during neonatal period because she was doing well, no evidence of congestive heart failure and around 80 beat per minute of heart rate. The serologic markers for diagnosis of neonatal lupus are the autoantibodies specific to SS-A/Ro and/or SS-B/La. These antibodies are produced by the mother and passed to the fetus through the placenta. Autoantibodies of cytoplasmic SS-A antigens or SS-B antigen were found in the blood of this patient and her mother. We report a case of neonatal lupus syndrome with congenital atrioventricular dissociation with Rt. Bundle branch block and hematologic abnormality.
Antibodies
;
Autoantibodies
;
Body Weight
;
Bradycardia
;
Bundle-Branch Block
;
Cesarean Section
;
Cytoplasm
;
Dermatitis
;
Diagnosis
;
Echocardiography
;
Female
;
Fetus
;
Gestational Age
;
Heart Block*
;
Heart Failure
;
Heart Rate
;
Heart*
;
Humans
;
Mothers
;
Pericardial Effusion
;
Placenta
;
Pregnancy
4.Comparison of Direct-labeling Method of Antibody with 99mTc and 188Re.
Chang Woon CHOI ; Sang Moo LIM ; Kwang Sun WOO ; Wee Sup CHUNG ; Tae Hyun CHOI ; Soo Jeong LIM
Korean Journal of Nuclear Medicine 1999;33(1):84-93
PURPOSE: We investigated the direct labeling method of antibody with 99mTc and 188Re and examined the stability and function of these labeled compounds in in vitro and in vivo. MATERIALS AND METHODS: Disulfide bond of nonspecific human IgG was reduced to -SH group by 2-mercaptoethanol. Stannous ion was used to reduce 99mTc and 188Re. The stability of 99mTc-IgG and 188Re-IgG was estimated upto 24 hrs. Biodistribution was evaluated in abscess bearing rats at 4 and 24 hr post-injection of 99mTc or 188Re labeled IgG. RESULTS: The number of -SH group per reduced IgG molecule was 2.34. The labeling yield of 99mTc-IgG and 188Re-IgG were 90% and 95%, respectively. The stability of 99mTc-IgG at 1, 4, 6 and 24 hr was 91%, 83%, 78%, 7% and that of 188Re-IgG, high uptake was found on kidney, blood, stomach and abscess (9.42+/-0.68, 1.43+/-0.24, 0.86+/-0.18, 0.72+/-0.10 %ID/g, respectively). The uptakes at 24 hr were kidney, abscess, stomach, and blood in descending order. In case of 188Re-IgG, high uptake at 4 hr post injection appeared on kidney, blood, abscess and stomach (3.92+/-0.62, 1.32+/-0.08, 0.88+/-0.01, 0.26+/-0.06, respectively). The upatkes at 24 hr were kidney, abscess, blood abd stomach in descending order. The abscess to blood uptake ratio of 99mTc-IgG was 0.5 at 4 hr and 2.02 at 24 hr and that of 188Re-IgG was 0.67 and 1.29. CONCLUSION: 99mTc-IgG and 188Re-IgG and 188Re-IgG canbe labeled efficiently with direct labeling method. However, 99mTc-IgG and 188Re-IgG, labeled with direct method, was unstable. Further study in needed to enhance the stability of the antibody labeling.
Abscess
;
Animals
;
Humans
;
Immunoglobulin G
;
Kidney
;
Mercaptoethanol
;
Rats
;
Stomach
5.Endoscopic Alcohol Injection Therapy in Bleeding Peptic Ulcers.
Kyoo Wan CHOI ; Yong Bum YOON ; In Sung SONG ; Chung Yong KIM ; Hyun Chae JUNG ; Poong Lyul RHEE ; Sang Woon CHOI ; Tae Ho KIM ; Young Tae KIM
Korean Journal of Gastrointestinal Endoscopy 1994;14(2):166-170
Bleeding that recur or continues after hospital admission for an acutely bleeding peptic ulcer is the single most important factor adversely affecting prognosis. The endoscopic findings of stigmata of recent hemorrhage such as active bleeding, a visible vessel or fresh blood clots in peptic ulcer indicate relatively high rebleeding risk. 30 patients with stigmata of recent hemorrhage in bleeding peptic ulcers were treated by endoscopic alcohol injection therapy during the 3-year period from August 1989 to July 1992. 30 cases included 24 gastric ulcers, 4 duodenal ulcers, and 2 stomal ulcers. 8 of these were actively bleeding at the time of endoscopy and non-bleeding visible vessels were identified in 15 patients and fresh blood clots were present in 7. 12 of total 30 cases had rebleeding or continuous bleeding. 3 of 8 with active bleeding, 5 of 15 with non-bleeding bisible vessels, and 4 of 7 with fresh blood clots had rebleeding. Emergency operations were done in 4 cases. There was no complication such as perforation and mortality. We think that this modality of endoscopic hemostasis is safe and simple, but further randomized controlled trials will be needed to evaluate the efficacy of hemostasis by endoscopic alcohol injection therapy.
Christianity
;
Duodenal Ulcer
;
Emergencies
;
Endoscopy
;
Hemorrhage*
;
Hemostasis
;
Hemostasis, Endoscopic
;
Humans
;
Mortality
;
Peptic Ulcer*
;
Prognosis
;
Stomach Ulcer
;
Ulcer
6.Two Cases of Triple Gastric Cancer.
Tae Byung PARK ; Kye Suk KWON ; Won Jae CHUNG ; Yong Woon SHIN ; Byung Yup AHN ; Chan Sub PARK ; Sung Tae OH ; Kyung Rae KIM ; Young Chae CHOO
Korean Journal of Gastrointestinal Endoscopy 1992;12(1):57-60
Multiple gastric caner, now considered to be a sort of multiple primary cancer by Moertel's classification, is a special type of cancer in which two or more tumor lesions arise independently from the stomach. Although its incidence is rare and it has never been reported in Korea yet, the report of multiple gastric cancer is increasing with lengthened life survival and improved diagnostic method. We recently experienced two cases of triple gastric cancer, the one in 53-years-old male who had well differentiated adenocarcinoma(EGC IIb+c) on antrum, poorly differentiated adenocarcinoma on cardia and moderately differentiated adenocarcinoma on mid-body, and the other in 65-years-old female who had two poorly differentiated adenocarcinoma on cardia and anterior wall of low body and moderately differentiated adenocarcinoma (EGCIIc) on posterior wall of low body. Triple gastric cancer is rare, so we reported 2 cases of triple gastric cancer.
Adenocarcinoma
;
Cardia
;
Classification
;
Female
;
Humans
;
Incidence
;
Korea
;
Male
;
Stomach
;
Stomach Neoplasms*
7.Studies on Scintillation Proximity Assay for the mesurement of alpha - hCG.
Tae Hyun CHOI ; Chang Woon CHOI ; Sang Moo LIM ; Wee Sup CHUNG ; Soo Jeong LIM ; Su Jin LEE ; Tae Sup LEE ; Ok Doo AWH ; Kwang Sun WOO
Korean Journal of Nuclear Medicine 2002;36(2):133-139
No abstract available.
8.Hunter Syndrome.
Young You KIM ; Chul Min LEE ; Tae Woon KIM ; Young Hun CHUNG
Journal of the Korean Pediatric Society 1980;23(2):153-157
A 7-year and 5-month old boy with Hunter syndrome is presented. Progressive mental retardation with hearing loss, speech disturbance and growth retardation developed at 1 year of age. Physical findings included dull facial appearance, short stature, macrocephaly, short neck, non-tender scalp nodules, large tongue, thick lips with opened mouth, flat nasal bridge, hirsutism, hepatomegaly, umbilical hearnia, undescended testes, painful limitation of abduction at shoulders and of extension at elbows, and claw hands, but corneal clouding is absent. Characteristic radiologic findings are thickened calvarium, J-shaped sella turcica, poor pneumatization of mastoid, rather broad and short metacarpal bones with tapering in the proximal ends, retarded bone age, inferior beaking of T12 to L4 vertebral body and posterior displacement of L1 vertebral body. An oral glucose tolerance test is abnormal and family history shows the pattern of x-linked inheritance.
Animals
;
Beak
;
Cryptorchidism
;
Elbow
;
Genes, X-Linked
;
Glucose Tolerance Test
;
Hand
;
Hearing Loss
;
Hepatomegaly
;
Hirsutism
;
Hoof and Claw
;
Humans
;
Infant
;
Intellectual Disability
;
Lip
;
Macrocephaly
;
Male
;
Mastoid
;
Metacarpal Bones
;
Mouth
;
Mucopolysaccharidosis II*
;
Neck
;
Scalp
;
Sella Turcica
;
Shoulder
;
Skull
;
Tongue
9.Anesthesia for Renal Transplantation - Report of 24 Cases.
Sung Nyeun KIM ; Kap Sung KIM ; Jee Sop YOO ; Tae Ho CHUNG ; Se Ung CHON ; Woon Hyok CHUNG
Korean Journal of Anesthesiology 1977;10(1):43-53
This is a report of anesthesia done for 24 cases of renal transplantation performed at St. Mary's Hospital, Catholic Medical college, Seoul, Korea, between 25 March 1969 and 19 August 1976. The recipient of renal transplantation show many critical conditions which require special considerations in performing anesthesia. The patients preoperative condition should be evaluated more carefully than most other kinds of surgical patients and anesthesia technic also must be selected specially. All kidney grafts were obtained from living donors. The family linkage of 24 donors was: 7 cases(29.1%) were from parents, 3 cases(12.5%) from children, 9 cases (37.5%) from siblings, 3 cases(12. 5%) from other relatives and 2 cases (8. 3%) were from nonrelated prsons. In the sex distribution of the donors, each sex was equally distributed.: All donors were anesthetized by means of endotracheal anesthesia using halothane, nitrous oxide and oxygen. As to complications during the nephrectomy of donors, a case of hiccup and two cases of pleural tear were encountered. The removed kidney was perfused with Hartmanns solution before transplantation and the choice of anesthetic agents caused no problems in the function of transplanted kidneys. The recipients had histories of chronic glomerulozephritis or pyelonephritis from 6 months to 32 years and showed uremic conditions. Their mean age was 38 years, ranging from 18 years to 59 years. The most frequent age group of the recipients was the 30 and 40 year group. Most recipients were males; among 24 cases, only 3 were females. Most of the recipients had decreased function of heart and lungs, severe anemia difficult to correct by blood transfusion(Hb, 7. 3 gm%, Hct. 24, 2%), increased BUN(70. 36+/-31. 34 mg/dl), hyperkalemia (4. 67+/-0. 63 mEq/L), poor and fragile veins, bleeding tendency and decreased kidney function(serum creatinine 10. 48 edmea, +/-2. 99 mg/dl). Prolonged medication to the recipient was another hazard to anesthesia. To lessen the risk during the anesthesia maintenance, preoperative preperation of the recipient The Journal of The Korean Society of Anesthesiologists Vol. 10, No. 1, 1977 Premedication of the recipients was perfor med by valium(515 mg) and atropine(0. 4 0. 5 mg) one hour before anestl esia. For tlie anesthetic technic, endotracheal anesthesia was applied to aI1 cases. Induction was done with intravenous pentothal soium, l00~ 200 mg or Epontol 250~500mg. As to the muscle relaxant to facilitate intubation, succinylchline for ll cases of the initial period of the transplantation, later gallamine for one case and pancuronium for the recent 12 cases. All anesthesia was maintained with halothane, nitrous oxide and oxygen. Muscle relaxants were used in al) cases during the surgery: succinylcholine drip for the initial 7 cases, d-Tubocurarine for 2 cases, gallamine for 2 cases and pancuronium for the recent 12 cases. Galllamine seems to be not contraindicated, as far as the active diuresis could be anticipated after the transplantation. Amount of blood transfused during operation was 2, 041 ml in average, ranging from 800 ml to 5000 ml and fluid infused was 1, 242 m] of Hartmann's sol. and/or other solutions. Respiration was controlled manually or mechanically. During the anesthesia, 16 cases of hypertension, 7 cases of arterial hypotension, 3 cases of arrhythmia, one cas of tight chest and one case of tachycardia, were encountered. Emergence of anesthesia was within 15 minutes. After the transplantation, diuresis started in 33 minutes on the average and most patients showed marked diuresis in which urine volume of 24 hours was 10, 164 ml on the average. The total surgical procedure lasted 4 hours and 50 minutes on the average, ranging from 3 hours 50 minutes to 7 hours. The ischemic tine of the removed kidney was 32 minutes in average. Followup of the patients showed that 10 cases died out of 24 cases between 4 months and 4 years after the surgery Patients surviving more than 1 year were 11 cases out of 15 cases(73. 3%), two cases out of 8 cases(25%) survived more than 2 years and two cases out of 8 cases(25%) more than 3 years. One case had the longest survival of 7 1/3 years.
Anemia
;
Anesthesia*
;
Anesthetics
;
Arrhythmias, Cardiac
;
Child
;
Creatinine
;
Diuresis
;
Female
;
Follow-Up Studies
;
Gallamine Triethiodide
;
Halothane
;
Heart
;
Hemorrhage
;
Hiccup
;
Humans
;
Hyperkalemia
;
Hypertension
;
Hypotension
;
Intubation
;
Kidney
;
Kidney Transplantation*
;
Korea
;
Living Donors
;
Lung
;
Male
;
Nephrectomy
;
Nitrous Oxide
;
Oxygen
;
Pancuronium
;
Parents
;
Premedication
;
Propanidid
;
Pyelonephritis
;
Respiration
;
Seoul
;
Sex Distribution
;
Siblings
;
Succinylcholine
;
Tachycardia
;
Thiopental
;
Thorax
;
Tissue Donors
;
Transplants
;
Tubocurarine
;
Veins
10.Efficacy and Longterm Follow-up of Endoscopic Variceal Ligation on Esophageal Varix Bleeding.
Yong Bum YOON ; In Sung SONG ; Chung Yong KIM ; Hyo Suk LEE ; Jung Hwan YOON ; Hyun Chae CHUNG ; Yong Tae KIM ; Dong Ho LEE ; Kook Lae LEE ; Han Joo LEE ; Woon Tae CHUNG ; Jae Gyu KIM
Korean Journal of Gastrointestinal Endoscopy 1996;16(5):707-714
Hemorrhage from esophageal varices is a catastrophic complication of portal hypertension. Endoscopic variceal ligation(EVL) is a newly developed technique that may replace Endoscopic injection sclerotherapy(EIS). But there are a few reports of longterm follow-up of EVL in Korea. We analysed 42 patients to evaluate longterm effect of EVL for esophageal varices. Total 689 variceal ligations were performed during 117 separate EVL sessions. Control rate of acute bleeding was 90.5%(38 of 42 patients). Four patients who were failed on control of acute bleeding were taken EIS with successful bleeding control. The eradication rate of esophageal varix was 76.2%(32 of 42 patients), the mean session for eradication of varix was 3,0(2-6), the number of bands per person was 16.0(5-41), and the number of bands per session was 6.0(4-11). Rebleeding after initiation of EVL occured in 1l of 42 patient(26,2%). 81.8% of rebleeding occurred 6 months later after EVL was done. The mortality rate and survival rate after varix eradication during follow-up period(after 6-45 months, mean: 15.5 months) was each 14.3%(6/42) and 85.7%(36/ 42). The causes of death were hepatic failure (3/6), esophageal variceal bleeding(2/ 6) and hepatic encephalopathy(l/6). After EVL, the~re were no serious treatment-re lated complications: except mild complications: mild chest pain in 5 patient(12.0%), mild substernal pain in 7 patients(16.6%). These results suggest that EVL is a safe and effective method for treatment of variceal bleeding control and eradication of esophageal varices with least serious complication. But regular periodic examination(interval of 4-6 months) and repeat EVL after eradication of varices should be required becuse of recurrence of varix and rebleeding.
Cause of Death
;
Chest Pain
;
Esophageal and Gastric Varices*
;
Follow-Up Studies*
;
Hemorrhage*
;
Humans
;
Hypertension, Portal
;
Korea
;
Ligation*
;
Liver Failure
;
Mortality
;
Recurrence
;
Survival Rate
;
Varicose Veins